2019 State of the Science Firefighter Cancer Symposium

2019 年消防员癌症科学现状研讨会

• 批准号: 9763183
• 负责人: Alberto Juan Caban-Martinez
• 金额: $ 2万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9763183
• 关键词: 2019; State; Science; Firefighter; Cancer

PROJECT SUMMARY / ABSTRACT Firefighters in the United States are at an increased risk for a variety of cancers, as demonstrated by recent epidemiologic studies by the NIOSH. Reduction of cancer risk is an extremely important issue for the fire service, but a number of critical barriers including development of uniform data collection instruments, exposure assessment, better understanding of cancer mechanisms, effective cancer screening and inclusion of potentially vulnerable groups such as women firefighters, must be overcome in order to achieve this goal. The passage of the 2018 Firefighter Cancer Registry Act, to be administered by NIOSH, adds an even more time sensitive need to establishing a coordinated approach to overcoming the critical barriers. We have received notice of partial funding from the Sylvester Comprehensive Cancer Center (SCCC) at the University of Miami to help support a national meeting on cancer research in the fire service, and have also developed the framework for the Fire Fighter Cancer Cohort Study (FFCCS), a multicenter prospective study of cancer in the fire service. We propose to build on this foundation to address the critical barriers to reduction of firefighter cancer risk through completion of the following specific aims: 1) Support implementation of the Firefighter Cancer Registry Act; 2) Establish a unified approach to development of cancer risk surveys and prospective exposure monitoring; 3) Identify putative cellular mechanisms involved in elevated cancer risk in firefighters; 4) Develop a coordinated approach to improving cancer screening in the fire service; and 5) Broad dissemination of symposium findings through stakeholder groups, symposium evaluation and scientific proceedings publication via a dedicated symposium website. These aims will be accomplished through organization of a fire service cancer conference on June 10- 11th, 2019 at the SCCC in Miami. Conference attendees will include members of the FFCCS Oversight and Planning Board, composed of representatives of multiple fire service organizations including labor, administration, NGOs, and other affinity organizations including but not limited to the iWomen, as well as academics with active research addressing firefighter cancer. NIOSH representatives tasked with organization of the Firefighter Cancer Registry will present their development needs to the assembled group, who will develop an action plan to meet these needs. A harmonized firefighter cancer risk survey and approach to development of an exposure matrix and exposure reporting systems will be developed building on the current survey and preliminary exposure matrix used in the FFCCS, as well as the National Fire Operations Reporting System and the Personal Exposure Report used in the state of Florida. Academics with expertise in toxicology and cancer mechanisms will identify potential carcinogenic pathways for further evaluation in the fire service. Academic and fire service experts on cancer screening in the fire service will develop a research and implementation plan to guide future efforts. The proposed conference will result in a roadmap to address cancer prevention research in the fire service, and also support the newly mandated Firefighter Cancer Registry.

项目总结/摘要 美国的消防员患各种癌症的风险增加，最近的研究表明， NIOSH的流行病学研究。降低癌症风险对消防部门来说是一个极其重要的问题， 但也存在一些关键障碍，包括开发统一的数据收集工具， 评估，更好地了解癌症机制，有效的癌症筛查和纳入潜在的 为了实现这一目标，必须克服妇女消防员等弱势群体的困难。的通过 由NIOSH管理的2018年《消防员癌症登记法》增加了一个对时间更加敏感的需求 建立一个协调的方法来克服关键的障碍。我们收到了部分 来自迈阿密大学西尔维斯特综合癌症中心（SCCC）的资金， 全国消防癌症研究会议，并制定了消防框架 战斗机癌症队列研究（FFCCS），一项多中心的前瞻性研究癌症在消防服务。我们提出 在此基础上，通过完成以下工作来解决降低消防员癌症风险的关键障碍： 1）支持实施《消防员癌症登记法》; 2）建立一个 制定癌症风险调查和前瞻性暴露监测的统一方法; 3）确定推定的 参与消防员癌症风险升高的细胞机制; 4）制定协调的方法， 改善消防人员的癌症检查工作;及五）透过下列途径，广泛宣传研讨会的成果： 利益攸关方团体、专题讨论会评价和通过专门的专题讨论会发表科学会议记录 网站这些目标将通过在六月十日组织一个消防癌症会议来实现， 2019年11月11日在迈阿密的SCCC。会议与会者将包括FFCCS监督和 规划委员会，由包括劳工在内的多个消防服务组织的代表组成， 政府、非政府组织和其他相关组织，包括但不限于iWomen，以及 积极研究消防员癌症的学者。NIOSH代表负责组织 消防员癌症登记处将提出他们的发展需要，以组装组，谁将开发 一个行动计划来满足这些需求。协调一致的消防员癌症风险调查和发展方法 将在当前调查的基础上制定风险矩阵和风险报告系统， FFCCS中使用的初步暴露矩阵，以及国家消防业务报告系统， 佛罗里达州使用的个人暴露报告。具有毒理学和癌症专业知识的学者 机制将确定潜在的致癌途径，以便在消防部门进行进一步评估。学术和 消防部门的癌症筛查专家将制定一项研究和实施计划， 指导今后的努力。拟议的会议将产生一个路线图，以解决癌症预防研究 在消防服务，并支持新授权的消防员癌症登记处。