权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Initial Development and Validation of a Translational Approach to AUD Definition and Measurement

澳元定义和衡量转化方法的初步开发和验证

基本信息

批准号：
9763390
负责人：
Cassandra Lee Boness
金额：
$ 4.41万
依托单位：
UNIVERSITY OF MISSOURI-COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-08 至 2020-09-07
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9763390
关键词：
Address Alcohol dependence Basic Science Behavior Behavioral Big Data Clinical Clinical Treatment Clinical assessments Collaborations Communities Critiques Data Set Development Diagnosis Diagnostic Diagnostic and Statistical Manual of Mental Disorders Dimensions Disease Drops Etiology Evaluation Exposure to Faculty Feedback Foundations General Population Genetic Goals Heterogeneity Immersion Investigative Technique Individual Informatics Intervention Interview Knowledge Language Literature Measurement Measures Mental disorders Mentors Methodology Methods Modeling Movement National Institute of Mental Health Nature Neurobiology Outcome Outpatients Participant Phenotype Play Positioning Attribute Property Psychiatric Diagnosis Psychometrics Public Health Public Policy Publications Questionnaires Recording of previous events Research Research Domain Criteria Research Methodology Research Training Role Sampling Seminal Series Severities Statistical Methods Substance Use Disorder Symptoms Techniques Testing Training Translational Research United States National Institutes of Health Validation Work addiction alcohol abuse therapy alcohol use disorder base career college disease classification endophenotype evidence base experience improved innovation precision medicine response skills systematic review tenure track theories translational approach university student

项目摘要

(7) PROJECT SUMMARY/ABSTRACT Specific Aims The current proposal aims to integrate core AUD constructs and theories, including promising endophenotypes, into an RDoC framework. This systematic integration will be used to derive a set of construct valid AUD “diagnostic criteria” that will be validated in a college, community, and treatment sample. The resulting measure will consist of phenotypic-based criteria that are well-suited for treatment purposes, given they match directly to individual treatment targets, consistent with the precision medicine approach. Method Towards these aims, a systematic review of reviews on the topics of AUD etiology, core theories, and important endophenotypes will be conducted. Seminal, replicable findings will be integrated into the RDoC matrix (Aim 1). Once the core AUD domains have been identified, a second review will be conducted with the goal of identifying existing questionnaire and interview items that address each addiction-related RDoC domain. The appropriateness of these item/domain categorizations will be evaluated by Dr. Sher and consultants in order to provide feedback on the validity of the categorizations (Aim 2). Lastly, the items identified in Aim 2 will be used to develop a diagnostic measure of AUD using advanced statistical methods such as IRT, using the help of Drs. Merkle and Bucholz (consultants) and Dr. Sher (sponsor; Aim 3). An MTurk sample of participants (N = 1,000) will be used for the item evaluation stage of measure development, and a college student (N = 1,000), outpatient (N = 150), and treatment (N = 150) sample will be used for the clinical refinement and external validation stage. Long-Term Objectives The over-arching goal of the proposed project is to develop an objective measure of AUD that is informed by basic translational science, consistent with the RDoC framework. Through the systematic integration of seminal work on AUD etiology into an RDoC framework, which has not been previously accomplished, the current study is well-positioned to produce a construct-valid measure of AUD that can be used to inform clinical treatment decisions. The proposed project can contribute to the movement towards developing personalized AUD intervention efforts by focusing on the specific domains in which individuals are experiencing symptoms and therefore overcoming the current issues related to treatment of widely heterogeneous AUD presentation. Training Aims The current proposal will serve as an important starting place for my long-term objective of building a more reliable and construct-valid diagnostic framework for use in the assessment and treatment of AUDs. The proposal will allow the applicant to gain valuable experience in translational science and its application within an RDoC framework, plus knowledge in analysis of big data, test construction, and psychometric evaluation. The nature of these training experiences will provide me with an immersive experience through close collaboration with mentors and exposure to new research and statistical methods. Thus, successful completion of these training aims will provide the foundation for my career objective of obtaining a tenure-track research position investigating AUD nosology and assessment with the goal of using these findings to improve clinical outcomes.

(7) 项目概要/摘要具体目标目前的提案旨在整合核心 AUD 结构和理论，包括有前途的内表型、到 RDoC 框架中。这种系统集成将用于派生出一组有效的 AUD 构造将在大学、社区和治疗样本中验证的“诊断标准”。由此产生的措施将包含基于表型的标准，这些标准非常适合治疗目的，因为它们直接匹配个性化治疗目标，与精准医疗方法一致。方法为了实现这些目标，对 AUD 病因学、核心理论和重要内容等主题的综述进行了系统回顾。将进行内表型分析。开创性的、可复制的发现将被整合到 RDoC 矩阵中（目标 1）。 Once the core AUD domains have been identified, a second review will be conducted with the goal of identifying 针对每个与成瘾相关的 RDoC 领域的现有调查问卷和访谈项目。这 Sher 博士和顾问将评估这些项目/领域分类的适当性，以便提供有关分类有效性的反馈（目标 2）。最后，将使用目标 2 中确定的项目在 Drs 的帮助下，使用 IRT 等先进统计方法开发 AUD 诊断措施。 Merkle 和 Bucholz（顾问）以及 Sher 博士（发起人；目标 3）。 MTurk 参与者样本（N = 1,000）将用于措施制定的项目评估阶段，一名大学生（N = 1,000），门诊患者 (N = 150) 和治疗 (N = 150) 样本将用于临床改进和外部验证阶段。长期目标拟议项目的总体目标是制定澳元的客观衡量标准，该衡量标准的依据是基础转化科学，与 RDoC 框架一致。通过系统整合开创性的将 AUD 病因学纳入 RDoC 框架，这在之前尚未完成，目前的研究能够很好地产生 AUD 的结构有效测量值，可用于指导临床治疗决定。拟议的项目可以为开发个性化澳元的运动做出贡献通过关注个人正在经历症状和症状的特定领域来进行干预工作因此克服了当前与处理广泛异质的澳元表现相关的问题。培训目标当前的提案将作为我的长期目标的重要起点，即建立一个更加可靠且构建有效的诊断框架，用于评估和治疗 AUD。这提案将使申请人能够获得转化科学及其应用方面的宝贵经验 RDoC 框架，加上大数据分析、测试构建和心理评估方面的知识。这这些培训经历的本质将通过密切合作为我提供身临其境的体验与导师并接触新的研究和统计方法。至此，顺利完成了这些培训目标将为我获得终身研究职位的职业目标奠定基础调查 AUD 疾病学和评估，目的是利用这些发现来改善临床结果。