Effects of Functional Food Diets on Cardiometabolic and Metabolomics Profiles in Minority Youth

项目概要/摘要 这份建议书概述了一个职业发展计划，以帮助Jaapna Dhillon博士完成博士后培训 建立一个独立的研究项目，专注于个性化的饮食干预， 少数群体的心脏代谢风险。她的培训将在一个多学科小组进行， 具有营养科学、健康差异、分子细胞生物学、代谢组学研究专长的科学家 和计算生物学。她的顾问团队将提供出色的培训环境， 为了填补她的工具包中的关键空白，她需要使用综合和个性化的营养方法。这 该奖项将提高她在开发文化敏感的营养干预和心血管疾病方面的知识。 生理学，并提供代谢组学和计算生物学的高级培训。培训期间 在这个奖项的第一阶段，她将加强她的学术活动，建立重要的合作，并获得 这些关键数据将确保她成功过渡到独立。理由：饮食相关的发病率 心脏代谢紊乱在种族/少数民族群体中以惊人的速度增加，如亚洲人和 西班牙裔，比美国的非西班牙裔白人高得多。[8]的一项建议。但无论 饮食质量的改善将不同程度地影响心脏代谢疾病高危少数群体 比白人高的风险还不太清楚。坚果、全谷类和蔬菜等功能性食品 可以帮助改善心血管疾病和降低2型糖尿病的风险。然而，大多数关于 功能性食品和健康已经压倒性地在中年到老年非西班牙裔白色 成年人，年轻的少数群体人口被严重忽视。在早期生活中适应功能性食物饮食 阶段可以预防或改善少数人群在以后的生活中代谢紊乱， 慢性代谢性疾病我们的中心假设是，适应个性化的功能 在生命早期阶段的饮食对碳水化合物和脂质调节途径有更大的有益影响 与处于危险中的白色青年相比，处于发生心脏代谢紊乱危险中的少数民族青年。设计：该 指导阶段研究将1）检查杏仁对血糖调节途径的影响， 代谢组学技术和2）为开发和测试模型提供初步数据， 预测杏仁对少数民族青年代谢结果的影响。独立阶段研究将 评估富含功能性食物的个性化饮食对碳水化合物途径的长期影响， 血脂调节与肠道微生物组和少数民族青年高风险心血管结局的关系 心脏代谢疾病。相关性：拟议的研究将为以下研究提供初步证据基础： 个性化功能食品干预对少数民族青年的健康益处。这种创新的饮食策略 在降低风险和改善饮食相关的心脏代谢紊乱方面， 该人群的传统饮食建议。

PROJECT SUMMARY / ABSTRACT This proposal outlines a career development plan to help Dr. Jaapna Dhillon complete her postdoctoral training and establish an independent research program focused on personalized dietary interventions to reduce cardiometabolic risk in minority populations. Her training will be conducted in a multidisciplinary group of scientists with research expertise in nutrition science, health disparities, molecular cell biology, metabolomics and computational biology. Her advisory team will provide an outstanding training environment that will allow her to fill critical gaps in her toolkit needed to use an integrative and personalized approach to nutrition. This award will enhance her knowledge in developing culturally sensitive nutrition interventions and cardiovascular physiology, and provide advanced training in metabolomics and computational biology. During the training phase of this award, she will strengthen her scholarly activities, establish important collaborations, and acquire critical data that will ensure her successful transition to independence. Rational: The incidence of diet-related cardiometabolic disorders is increasing at an alarming rate in racial/ethnic minority groups such as Asians and Hispanics, and are much higher than Non-Hispanic Whites in the United States. [8]. However, whether improvements in diet quality will influence minority groups at high risk of cardiometabolic diseases differentially than Whites at high risk is not well understood. Functional foods such as nuts, whole grains and vegetables can help ameliorate cardiovascular disease and reduce the risk of type 2 diabetes. However, most studies on functional foods and health have been overwhelmingly performed in middle-aged to older non-Hispanic White adults, with young minority populations being greatly neglected. Adapting a functional food diet at earlier life stages may prevent or ameliorate metabolic disorders later in life in minority populations that are at greater risk for developing chronic metabolic diseases. Our central hypothesis is that adapting a personalized functional food diet at earlier life stages will have greater beneficial effects on carbohydrate and lipid regulation pathways in minority youth at risk for developing cardiometabolic disorders compared to White youth at risk. Design: The mentored phase study will 1) examine the effects of almonds on blood glucose regulation pathways using metabolomics techniques and 2) provide preliminary data for the development and testing of a model that can predict effects of almonds on metabolic consequences in minority youth. The independent phase study will evaluate the long term effects of a personalized diet rich in functional foods on pathways of carbohydrate and lipid regulation in relation to the gut microbiome and cardiovascular outcomes in minority youth at high risk for cardiometabolic disorders. Relevance: The proposed studies will provide an initial evidence base for the health benefits of personalized functional food interventions in minority youth. This innovative dietary strategy may be more effective at reducing risk and ameliorating diet-related cardiometabolic disorders than conventional dietary advice in this population.