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The Subgingival Microbiome in Non-Hispanic Black Women: Relationship to Periodontal Inflammation, Systemic Inflammation, and Preterm Birth

非西班牙裔黑人女性的龈下微生物群：与牙周炎症、全身炎症和早产的关系

基本信息

批准号：
9766394
负责人：
Irene Yang
金额：
$ 8.89万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-19 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9766394
关键词：
16S ribosomal RNA sequencing 37 weeks gestation Affect Appearance Area Behavioral Birth Birth Rate Cardiovascular system Communities Data Data Analyses Developed Countries Development Ecology Educational workshop Enrollment Environment Environmental Risk Factor Equilibrium Etiology Face Forsythia Funding Future Gestational Age Gingiva Goals Health Promotion Immune response Individual Infection Inflammation Inflammation Mediators Inflammatory Interdisciplinary Study Intervention Investigation Knowledge Late pregnancy Maternal Health Mentors Metagenomics Methodology Morbidity - disease rate Movement Newborn Infant Not Hispanic or Latino Oral Oral cavity Oral health Organism Outcome Parents Participant Pathway interactions Periodontal Diseases Periodontal Infection Physiological Play Population Porphyromonas gingivalis Pregnancy Pregnant Women Premature Birth Premature Infant Prevalence Prevention Prevention strategy Public Health Research Research Personnel Research Proposals Risk Risk Factors Role Serum Source Structure Techniques Training Treponema denticola Underserved Population United States Woman Yang beta diversity biobehavior career career development cytokine design early pregnancy ethnic minority population experience fetal health disparity indexing infant death innovation intrauterine infection microbial microbial community microbiome microbiome research microbiota microorganism minority health modifiable risk mortality oral microbiome pathogen periopathogen pregnant prenatal prevent programs racial and ethnic social socioeconomics subgingival biofilm subgingival microbiome vaginal infection

项目摘要

Project Summary/Abstract Preterm birth occurs at < 37 weeks gestation. It is associated with a host of newborn risks that increase the risk of preterm related infant death. The United States leads other industrialized nations in preterm birth rate and, for reasons unknown, non-Hispanic Black women in the U.S. have a 50% higher preterm birth rate compared to the overall national prevalence. Current preterm prevention strategies are limited due to lack of understanding about the underlying mechanisms of preterm birth. The association between intrauterine infection and preterm birth is well-established. Emerging research suggests that periodontal disease may be an etiologic source of this infection. Periodontal disease is an inflammatory condition that begins as a direct immune response to microorganisms that inhabit the subgingival biofilm. Pregnant women and racial/ethnic minorities are particularly at risk for periodontal disease. Gingival inflammation during pregnancy may allow for the movement of inflammatory products into the circulatory system and to the maternal-fetal unit, triggering an inflammatory cascade which may increase the likelihood of preterm birth. Critical to understanding the association between periodontal disease and preterm birth, is an understanding of the subgingival microbiome. This study, therefore, aims to: 1) Characterize the structure and diversity of the subgingival microbiome and of pregnant non-Hispanic Black women in early and late pregnancy. 2) Explore the relationship between the subgingival microbiome and localized inflammation. 3) Explore associations between localized and systemic inflammation, and gestational age at birth. Results from this study will inform an innovative approach to the assessment and intervention of periodontal disease in pregnant women as a potential modifiable target risk factor for preterm birth, thereby promoting maternal health, and preventing adverse birth outcomes for women and their newborns. The overarching goal of this K01 career development proposal is the development of Dr. Yang’s expertise in three areas: microbiome data analysis, oral health research, and health disparities research. The proposed project, in conjunction with the structured mentoring and training plan which includes didactic courses, workshops, and hands-on experience, are designed to facilitate this goal, as well as Dr. Yang’s long-term goal of developing an independently-funded biobehavioral research program that investigates how physiologic mechanisms combine with social, behavioral and environmental factors to give rise to maternal health disparities.

项目总结/文摘