HEAL Initiative: Coordinating Center to Support NIDA Preventing Opioid Use Disorder in Older Adolescents and Young Adults

HEAL 倡议：支持 NIDA 预防老年青少年和年轻人阿片类药物使用障碍的协调中心

• 批准号: 9891612
• 负责人: PHILLIP W GRAHAM
• 金额: $ 900.08万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9891612
• 关键词: Address; Adolescent and Young Adult; Adoption; Back; Budgets; Collection; Communication; Complex; Consensus; Consult; Consultations; Criminal Justice; Data; Data Analyses; Data Collection; Development; Economics; Ensure; Etiology; Evidence based intervention; Fostering; Foundations; Healthcare; Infrastructure; Intervention; Knowledge; Leadership; Logistics; Meta-Analysis; Methodology; National Institute of Drug Abuse; Opiate Addiction; Outcome; Policies; Population; Populations at Risk; Prevention; Prevention program; Prevention strategy; Preventive Intervention; Principal Investigator; Privatization; Procedures; Process; Program Evaluation; Recurrence; Research; Research Design; Research Personnel; Research Project Grants; Science; Site; United States; Work; addiction; comparative; computer infrastructure; cost; cost effectiveness; data integration; data management; data sharing; drug abuse prevention; economic evaluation; economic impact; evidence base; experience; health economics; implementation science; models and simulation; mortality; opioid epidemic; opioid misuse; opioid use disorder; prevent; service intervention; skills; systematic review; web site

PROJECT SUMMARY/ABSTRACT Although many evidence-based interventions have been identified to address the consequences of the opioid epidemic in the United States, much less progress has made been toward preventing the initiation of opioid misuse and the development of opioid use disorder (OUD). Recognizing the urgent need to fill this gap in knowledge, the National Institute on Drug Abuse (NIDA) is launching the HEAL Preventing Opioid Misuse and Opioid Use Disorder in Older Adolescents and Young Adults Initiative. Ten research projects (RPs), one coordinating center (CC), the steering committee (SC), and NIDA and other federal staff will collaborate to evaluate evidence-based prevention and intervention services for older adolescents and young adults across diverse settings and populations. We recognize that this important and complex endeavor requires exceptional coordination across a range of activities inherent to multi-site consortia. We propose a CC to facilitate cross-site activities and provide centralized support for the HEAL Prevention Collaborative (HPC). Our CC has five Specific Aims. We will provide centralized operational, administrative, and logistical infrastructure to facilitate consortium coordination and communication (Aim 1). We will provide implementation science expertise to understand the delivery and adaptation of evidence- based interventions within different programmatic settings (Aim 2). We will establish an infrastructure for cross-site data collection, management, harmonization, and data sharing (Aim 3). We will provide expert methodological and statistical consultation (Aim 4). We will conduct rigorous economic evaluation to guide decisionmakers in choosing prevention strategies that produce the greatest impact (Aim 5). Our CC team is led by multiple Principal Investigators—Drs. Phillip Graham and Kevin Conway—who are experienced leaders of multi-site studies and experts in consensus building, data harmonization, program evaluation, and addiction etiology. The broader team of Core leaders, key staff, and consultants brings robust scientific and implementation science skills interwoven with a deep understanding of the opioid crisis, prevention science, and the economics of opioid misuse and addiction. We offer proven computational infrastructure and statistical expertise to support all the required data management and analysis needs for the consortium. We are backed by RTI's unsurpassed experience and proficiency—born from successful leadership of over 40 other CCs—to ensure that we support and accomplish the aims. Collectively, we are well-prepared to apply prevention science concepts to the Nation's approach to the opioid crisis.

项目摘要/摘要 尽管已经确定了许多基于证据的干预措施来解决 在美国，opioid流行的进展少得多，而是为防止倡议的倡议 卵巢滥用和卵毒素使用障碍（OUD）的发展。认识到迫切需要填补这个 知识差距，美国国家药物滥用研究所（NIDA）正在推出预防阿片类药物的治疗 老年青少年和年轻人倡议中的滥用和阿片类药物使用障碍。十个研究项目 （RPS），一个坐标中心（CC），指导委员会（SC）和NIDA和其他联邦工作人员将 协作以评估老年青少年的基于证据的预防和干预服务 跨潜水员环境和人口的年轻人。我们认识到这个重要而复杂的 努力需要在继承多站点联盟的一系列活动中进行卓越的协调。 我们建议CC促进跨站点活动并为治疗提供集中支持 预防合作（HPC）。我们的CC有五个具体目标。我们将提供集中的运营， 行政和后勤基础设施，以促进财团的协调和沟通（AIM 1）。 我们将提供实施科学专业知识，以了解证据的交付和适应 - 基于不同程序设置的干预措施（AIM 2）。我们将建立一个基础设施 跨站点数据收集，管理，协调和数据共享（AIM 3）。我们将提供专家 方法论和统计咨询（AIM 4）。我们将进行严格的经济评估以指导 决策者选择产生最大影响的预防策略（AIM 5）。 我们的CC团队由多个主要调查员（DRS）领导。菲利普·格雷厄姆（Phillip Graham）和凯文·康威（Kevin Conway） 多站点研究的经验丰富的领导者以及共识建立，数据协调，计划的专家 评估和成瘾病因。核心领导者，主要人员和顾问的更广泛的团队带来了 强大的科学和实施科学技能与阿片类药物危机有深刻的了解， 预防科学以及阿片类药物滥用和成瘾的经济学。我们提供证明的计算 基础架构和统计专业知识，以支持所有必需的数据管理和分析需求 财团。我们得到了RTI无与伦比的经验和熟练程度的支持 - 从成功中出生 其他40多个CC的领导才能确保我们支持和实现目标。总的来说，我们是 精心准备将预防科学概念应用于该国对阿片类药物危机的方法。