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4/5 The Cumulative Risk of Substance Exposure and Early Life Adversity on Child Health Development and Outcomes

4/5 物质暴露和早年不幸对儿童健康发展和结果的累积风险

基本信息

批准号：
9898607
负责人：
CHARLES Alexander NELSON
金额：
$ 29.87万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2023-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9898607
关键词：
Address Affect Age Alcohol or Other Drugs use Analgesics Area Behavioral Biological Markers Biometry Brain Caring Child Child Development Child Health Childhood Cognitive Cohort Studies Communities Data Development Developmental Process Drug Exposure Education Electroencephalography Ensure Environment Environmental Exposure Environmental Risk Factor Epidemiology Ethics Exposure to Failure to Thrive Family Family Study Female of child bearing age Fentanyl Fright Government Agencies Growth Health Healthcare Heroin Individual Infant Legal Legal system Life Link Logistics Magnetic Resonance Imaging Measures Mediating Medical History Medicine Mental Health Modeling Mothers Neonatal Abstinence Syndrome Newborn Infant Opioid Outcome Parents Participant Pattern Pharmaceutical Preparations Phenotype Population Positioning Attribute Pregnancy Pregnant Women Premature Birth Protocols documentation Psychometrics Public Health Risk Rural School-Age Population Services Statistical Models Stress Structure Substance abuse problem Support Groups Techniques Testing Translating United States Vision Work behavioral outcome caregiving child protective service early life adversity experience fetal fetal opioid exposure imaging approach in utero innovation interest interpartner violence low socioeconomic status mortality risk multimodality myelination neurobehavioral neurodevelopment neuroimaging opioid epidemic opioid exposure opioid mortality opioid use postnatal prenatal prenatal exposure recruit relating to nervous system statistics study population tool

项目摘要

Project Summary/Abstract In utero exposure to opioids is causing significant societal concern given the worsening statistics of opioid-related use and abuse in women of child-bearing age. Over the past 2 decades, the rate of opiate usage across the US has increased by >300%, the number of opioid-related deaths has increased by ~500% and the number of newborns with neonatal abstinence syndrome (NAS) has increased by almost 400%. Thus, the opioid crisis represents a constellation of adverse conditions that places the developing child at significantly increased risk for mortality, small gestational growth, preterm delivery, postnatal failure to thrive and worsened neurobehavioral, scholastic, and societal outcomes. Emerging data indicate that in utero substance exposure is associated with a variety of negative health and cognitive outcomes. We assume the association between prenatal substance exposure and mental health/cognitive outcomes is mediated by the impact of prenatal substance exposure on brain development; we further assume that background environmental variables, such as low SES, low maternal education and high levels of stress exposure, moderate these developmental sequelae. In this linked proposal we will use a battery of behavioral and neuroimaging tools, beginning late prenatal and extending into school age, to examine the effects of opioid and adversity exposure on development.

项目总结/文摘