Translational Post-doctoral Training in Neurodevelopment

项目概要/摘要： 波士顿儿童医院神经发育（TPND）项目的转化博士后培训 旨在为有前途的博士后神经科学研究人员（MD，PhD或MD/PhD）提供 基本翻译主题的高级培训，从临床前考虑到 对患有一系列神经发育障碍的个体进行临床试验。大量 儿童、青少年和成人受开始于生命早期的神经发育障碍的影响， 植根于异常的大脑回路，并对大脑的关键领域产生深远的短期和长期影响。 发展，认知，社会互动和行为调节;然而，大多数可用的医疗和 心理治疗对神经发育障碍的影响有限。我们 建议建立在转化神经科学中心（TNC）和 波士顿儿童医院和哈佛医学院的认知神经科学实验室将提供 具有从临床前和认知神经科学实验室到临床 参与神经发育障碍的试验此外，该方案的一个关键前提是， 转化神经科学领域的研究培训需要导师在各个领域的专业知识， 神经发育障碍转化研究的连续性和正在进行的项目， 学员进行创新，高影响力的转化研究。17名教师导师将涉及 在2年的时间内（每年2名新学员）培训一系列最先进的翻译方法 反映TNC计划核心领域的神经发育科学，包括基础科学和 翻译方法以及在神经发育的治疗试验中对临床人群的应用 紊乱这一研究经验将补充教学和临床沉浸 旨在为学员提供成为成功的独立调查员所需的技能的经验， 这一重要的新兴领域。最终，这一研究经验将产生治疗， 通过减少护理的负担和成本以及现在与之相关的社会成本， 神经发育障碍此外，TPND将开发跨学科研究培训模式 为有前途的年轻科学家，这将对该领域产生变革性的影响。

Project Summary/Abstract: The Translational Post-doctoral Training in Neurodevelopment (TPND) Program at Boston Children's Hospital is designed to provide promising post-doctoral neuroscience investigators (MD, PhD or MD/PhD) with advanced training in essential translational topics ranging from preclinical considerations through implementation of clinical trials for individuals with a range neurodevelopmental disorders. Large numbers of children, adolescents, and adults are affected by neurodevelopmental disorders that begin early in life, are rooted in aberrant brain circuitry, and have profound short- and long-term consequences on critical domains of development, cognition, social interaction, and behavioral regulation; yet most available medical and psychological treatments have had limited impact on the course of neurodevelopmental disorders. We propose to build on the significant strengths of the Translational Neuroscience Center (TNC) and the Laboratories of Cognitive Neuroscience at Boston Children's Hospital and Harvard Medical School to provide trainees with research experiences ranging from pre-clinical and cognitive neuroscience labs through clinical trial involvement in neurodevelopmental disorders. In addition, a key premise of this program is that effective research training in the field of translational neuroscience requires both mentors with expertise in areas across the continuum of translational research with neurodevelopmental disorders and ongoing programs to support the trainees to conduct innovative, high impact translational research. The 17 faculty mentors will involve trainees over a 2 year period (2 new entrants per year) with a range of state of the art methods in translational neurodevelopmental science that reflect core areas of the TNC program including basic science and translational methods as well as application to clinical populations in therapeutic trials for neurodevelopmental disorders. This research experience will be supplemented with both didactic and clinical immersion experiences designed to provide trainees with the skills needed to be successful independent investigators in this critical and emerging field. Ultimately this research experience will yield treatments that have an impact on the field by reducing the burdens and costs of care and costs to society that is now associated with neurodevelopmental disorders. In addition, the TPND will develop models of interdisciplinary research training for promising young scientists that will have a transformative impact on the field.