Translational Post-doctoral Training in Neurodevelopment

项目摘要/摘要： 波士顿儿童医院神经发育(TPND)项目的翻译博士后培训 旨在为有前途的博士后神经科学研究人员(医学博士、博士或医学博士/博士)提供 基本翻译主题的高级培训，范围从临床前考虑到 为患有一系列神经发育障碍的个体实施临床试验。大量的 儿童、青少年和成年人都会受到早期神经发育障碍的影响， 根植于异常的大脑回路，并对以下关键领域产生深远的短期和长期影响 发展、认知、社会互动和行为调节；然而大多数可用的医学和 心理治疗对神经发育障碍的病程影响有限。我们 建议在翻译神经科学中心(TNC)和 波士顿儿童医院和哈佛医学院的认知神经科学实验室提供 具有从临床前和认知神经科学实验室到临床的研究经验的受训者 参与神经发育障碍的试验。此外，这个方案的一个关键前提是有效 翻译神经科学领域的研究培训需要两位具有以下领域专业知识的导师 神经发育障碍的转化性研究和正在进行的项目以支持 受训人员进行创新的、高影响力的翻译研究。这17名教师导师将涉及 为期2年的实习生(每年2名新入职人员)，掌握最先进的翻译方法 反映TNC计划核心领域的神经发育科学，包括基础科学和 神经发育治疗试验的翻译方法及其在临床人群中的应用 精神错乱。这项研究经验将与教学和临床浸泡一起补充。 旨在为受训人员提供成为成功的独立调查人员所需技能的经验 这一关键和新兴领域。最终，这种研究经验将产生对以下方面产生影响的治疗 通过减少护理的负担和成本以及社会成本，这一领域现在与 神经发育障碍。此外，技术和创新发展中心将开发跨学科研究培训模式。 对于有前途的年轻科学家来说，这将对该领域产生革命性的影响。

Project Summary/Abstract: The Translational Post-doctoral Training in Neurodevelopment (TPND) Program at Boston Children's Hospital is designed to provide promising post-doctoral neuroscience investigators (MD, PhD or MD/PhD) with advanced training in essential translational topics ranging from preclinical considerations through implementation of clinical trials for individuals with a range neurodevelopmental disorders. Large numbers of children, adolescents, and adults are affected by neurodevelopmental disorders that begin early in life, are rooted in aberrant brain circuitry, and have profound short- and long-term consequences on critical domains of development, cognition, social interaction, and behavioral regulation; yet most available medical and psychological treatments have had limited impact on the course of neurodevelopmental disorders. We propose to build on the significant strengths of the Translational Neuroscience Center (TNC) and the Laboratories of Cognitive Neuroscience at Boston Children's Hospital and Harvard Medical School to provide trainees with research experiences ranging from pre-clinical and cognitive neuroscience labs through clinical trial involvement in neurodevelopmental disorders. In addition, a key premise of this program is that effective research training in the field of translational neuroscience requires both mentors with expertise in areas across the continuum of translational research with neurodevelopmental disorders and ongoing programs to support the trainees to conduct innovative, high impact translational research. The 17 faculty mentors will involve trainees over a 2 year period (2 new entrants per year) with a range of state of the art methods in translational neurodevelopmental science that reflect core areas of the TNC program including basic science and translational methods as well as application to clinical populations in therapeutic trials for neurodevelopmental disorders. This research experience will be supplemented with both didactic and clinical immersion experiences designed to provide trainees with the skills needed to be successful independent investigators in this critical and emerging field. Ultimately this research experience will yield treatments that have an impact on the field by reducing the burdens and costs of care and costs to society that is now associated with neurodevelopmental disorders. In addition, the TPND will develop models of interdisciplinary research training for promising young scientists that will have a transformative impact on the field.