Planning for Bioinformatics and Molecular Biology Hands-on Training and Capacity Development for Research in Genomics of Non-Communicable Diseases in Nigeria (Dry-Lab and Wet-Lab Summer School)

项目概要/摘要： 现有大量证据表明，非传染性疾病的负担在低水平， 中等收入国家（LMICs）庞大且不断扩大，非传染性疾病占所有死亡人数的80 在中低收入国家。中低收入国家，特别是撒哈拉以南非洲，在强劲的研究产出方面排名很低， 支持和维持科学发现所需的适当人力和基础设施， 可以为预防和治疗非传染性疾病的做法和政策决策提供信息并加以改变。的 非洲人口和非洲环境的高度遗传多样性提供了无与伦比的 机会和潜力，研究基因组，表观遗传学和药物基因组学概况， 非洲人口中的非传染性疾病，包括三种最流行的非洲瘟疫：心血管疾病， 糖尿病和癌症非洲研究人员在基因组学方面的竞争力和知名度低， 表观遗传学和药物基因组学研究是一个严峻的挑战， 研究人员谁拥有的基础知识，技能，和负责任的行为，所需的属性， 非传染性疾病基因组学研究。迎接这一挑战是科学发现的基础， 创造新颖和创新的方法和产品，旨在提供高效和改进的 非洲卫生保健有可能提高非洲人的生活质量。专业和公共 基因组学教育和基因组学培训对于确保基因组学研究成果 转化为实践，政策和研究，以有利于公共卫生和医疗保健 行业尽管基因组研究在低收入和中等收入国家越来越受关注， 特别是在撒哈拉以南非洲地区，它在准备足够数量的 健康专业人员基因组学专家健康专业人员与日益增加的 这些传染病现在是低收入国家虚弱和死亡的主要原因。的目的 拟议的生物信息学和分子生物学暑期学校实践培训的目的是建立以下方面的能力： 在尼日利亚和整个（西非）非洲地区开展非传染性疾病基因组学研究， 有效的医疗服务和医疗创新。该项目的目标 包括增加研究生、博士后、住院医生和初级教职员工的数量， 非传染性疾病基因组学和遗传学方面的技能，从而提高其研究质量; 相关性;促进跨学科和多学科研究和研究人员团队;增强多样性 学员和研究对象的参与，并从事非人类基因组学的创新和过渡性研究 非传染性疾病。 !

Project Summary/Abstract: The available body of evidence shows that the burden of non-communicable diseases (NCDs) in low and middle-income countries (LMICs) is huge and expanding, and NCDs account for ~80% of all mortalities in LMICs. LMICs, especially sub-Saharan Africa, rank very low on robust research output and appropriate human capacity and infrastructure needed to support and sustain scientific discoveries that can inform and transform practice and policy decision-making on prevention and treatment of NCDs. The high genetic diversity of African populations and African environments provides unparalleled opportunities and potential to investigate the genomic, epigenetic and pharmacogenomics profile of NCDs in African populations, including the three most popular African plagues: cardiovascular diseases, diabetes and cancer. The low competitiveness and visibility of African researchers in genomics, epigenetics and pharmacogenomics research is a critical challenge, as is development of a critical mass of researchers who have the foundational knowledge, skills, and responsible conduct, attributes required for research on the genomics of NCDs. Meeting this challenge is fundamental to scientific discovery and creation of novel and innovative approaches and products designed to deliver efficient and improved healthcare in Africa with potential to increase quality of life of Africans. Professional and public genomics education and training in genomics are critical to ensuring that genomic research findings are translated to practice, policy and research in order to be of benefit to public health and the healthcare industry. Although, genomic research is gaining increasing visibility in low and middle-income countries (LMICs) especially sub-Saharan African region, it continues to lag behind in preparing a critical mass of health professions experts in genomics health professions commensurate with the growing burden of communicable diseases that are now the leading cause of debility and death in LMICs. The aim of the proposed summer school in bioinformatics and molecular biology hands-on training is to build capacity in genomics of NCDs in Nigeria and across the (West) African region in order to create excellent and effective healthcare delivery and medical innovations in the continent. The objectives of the project include increasing the number of graduate students, postdoc, resident doctors and junior faculty staff with skill in genomics and genetics of NCDs, thereby improving the quality of their research; increasing their relevance; promoting trans- and multi-disciplinary research and teams of researchers; enhancing diversity of trainees, and research subjects, and engaging innovation and transitional research in genomics of non- non-communicable diseases. !