Biopsychosocial Mechanisms Linking Gender Minority Stress to HIV Comorbidities

项目摘要/摘要 尽管少数性别妇女中艾滋病毒感染率很高，但人们对艾滋病毒知之甚少。 在这群人中的共病状况。了解潜在的艾滋病毒相关机制 健康差距人群中的并存是朝着推进健康公平迈出的重要一步。 为了解决这一知识差距，这项研究试图阐明耻辱和 黑人和拉丁裔少数族裔女性对艾滋病毒共病的生理应激。具体的 该项目的目标包括：(1)量化耻辱与慢性应激的纵向关系 生物标志物；(2)确定将慢性应激生物标志物与艾滋病毒共病联系起来的途径；以及(3) 检查慢性应激在连接耻辱、性激素和艾滋病毒共病的通路中的作用。 这些目标将使用现有的NIH资助的队列平台来实现，以登记和跟踪200名参与者 在一项为期24个月的混合方法前瞻性研究中，测量污名、慢性压力的生物标记物、性别 荷尔蒙、心理健康和心血管疾病风险。数据将在基线、6个月、12个月、18个月和24个月时收集。 这项纵向研究融合了深度访谈和定量的心理社会研究与临床 以及生物措施，以促进对社会和社会之间复杂关系的理解 体验和身体健康。这项创新的研究将确定 耻辱和艾滋病毒共病之间的联系。它对干预措施具有重要意义 健康差距和艾滋病毒携带者将提供新的信息，可用于指导 临床实践和减少健康差距。

Project Summary/Abstract Despite a high prevalence of HIV among gender minority women, very little is known about HIV comorbid conditions in this population. Understanding the mechanisms of underlying HIV-related comorbidities in this health disparity population is an important step toward advancing health equity. The address this gap in knowledge, the study seeks to elucidate pathways linking stigma and physiologic stress to HIV comorbidities among Black and Latina gender minority women. The specific aims of the project include to: (1) quantify the longitudinal relationship of stigma to chronic stress biomarkers; (2) identify pathways linking chronic stress biomarkers to HIV comorbidities; and (3) examine the role of chronic stress in pathways linking stigma, sex hormones, and HIV comorbidities. These aims will be met using existing NIH-funded cohort platforms to enroll and follow 200 participants in a 24-month, mixed-methods, prospective study to measure stigma, biomarkers of chronic stress, sex hormones, mental health, and CVD risk. Data will be collected at baseline, 6-, 12-, 18-, and 24-months. This longitudinal study blends in-depth-interviews and quantitative psychosocial research with clinical and biological measures to advance understanding of the complex relationships between social experiences and physical health. This innovative research will identify mechanisms underlying associations between stigma and HIV comorbidities. It has important implications for interventions with health disparity populations living with HIV and will provide novel information that can be used to guide clinical practice and reduce health disparities.