Technology-supported sedentary behavior intervention to promote recovery from cancer surgery

项目概要/摘要 本K 07提案详细说明了一个全面的职业发展计划， 申请人（Carissa Low，博士）具有成为一名 癌症研究的独立行为科学家基于她的临床背景 心理学和心理神经免疫学，洛博士的目标是发展可扩展的行为 对接受潜在治愈性癌症手术的患者进行干预，并检查 这些行为干预对临床结果和生物行为机制的影响。到 为了实现这些目标，候选人和她的导师设计了一个全面的计划， 在以下领域开展培训活动和指导研究： 体育活动和久坐行为研究的方法培训; 2）技术- 基于行为评估和干预;和3）外科肿瘤学的临床问题。的 拟议的指导研究将使用通过培训计划获得的知识和技能， 完善和测试一种新的技术支持的干预措施，以减少久坐行为， 以及癌症手术后的情况。利用新兴的移动的技术，干预将 整合实时可穿戴传感器和患者报告的术前等待数据 期间至出院后30天，以检测长时间久坐发作和移位低- 能量久坐行为与短暂的步行休息。行走的频率和持续时间 休息时间将根据参与者的波动症状负担进行个性化设置。经过初步 为了进行现场测试和改进算法和干预，Low博士将进行随机 技术支持的久坐行为干预的可行性对照试验。 可行性指标将包括保留、依从性和患者报告的可接受性，以及 主要结局包括客观活动水平、患者报告的抑郁和身体状况 症状和生活质量、循环炎症生物标志物和术后30天 成果。拟议的研究将为R 01申请提供试点数据，以充分资助 这项技术支持的久坐行为干预的随机试验。 虽然这项初步研究的重点是接受根治性手术治疗转移性肝癌的患者， 结肠直肠癌或腹膜癌，所提出的方法可能具有广泛的适用性 其他面临类似挑战的癌症患者群体。拟议 多学科培训和指导研究补充了Low博士以前的研究， 将促进她转变为移动的健康领域的独立研究员和领导者， 生物行为肿瘤学研究

Project Summary/Abstract This K07 proposal details a comprehensive career development program that will provide the applicant (Carissa Low, PhD) with the support, knowledge, and skills needed to become an independent behavioral scientist in cancer research. Building on her background in clinical psychology and psychoneuroimmunology, Dr. Low’s goals are to develop scalable behavioral interventions for patients undergoing potentially curative cancer surgery and to examine the effects of these behavioral interventions on clinical outcomes and biobehavioral mechanisms. To achieve these goals, the candidate and her mentors have designed a comprehensive program of training activities and mentored research in the following areas: 1) conceptual and methodological training in physical activity and sedentary behavior research; 2) technology- based behavioral assessment and intervention; and 3) clinical issues in surgical oncology. The proposed mentored research will use knowledge and skills acquired via the training plan to refine and test a novel technology-supported intervention to reduce sedentary behavior before and after cancer surgery. Capitalizing on emerging mobile technology, the intervention will integrate real-time wearable sensor and patient-reported data from the preoperative waiting period to 30 days post-hospital discharge to detect prolonged sedentary bouts and displace low- energy sedentary behavior with brief walking breaks. The frequency and duration of walking breaks will be personalized based on participants’ fluctuating symptom burden. After an initial study to field test and refine the algorithm and intervention, Dr. Low will conduct a randomized controlled feasibility trial of the technology-supported sedentary behavior intervention. Measures of feasibility will include retention, adherence, and patient-reported acceptability, and primary outcomes include objective activity levels, patient-reported depressive and physical symptoms and quality of life, circulating inflammatory biomarkers, and 30-day postoperative outcomes. The proposed research will provide pilot data for a R01 application to fund a fully powered randomized trial of the technology-supported sedentary behavior intervention. Although this initial study focuses on patients undergoing curative surgery for metastatic colorectal or peritoneal cancer, the proposed approach is likely to have broad applicability across other cancer patient populations facing similar challenges. The proposed multidisciplinary training and mentored research complement Dr. Low’s previous research and will facilitate her transition to an independent researcher and leader in mobile health and biobehavioral oncology research.