Fast Targeted Spectroscopic Imaging for Brain Tumor Imaging at 3T and 7T

用于 3T 和 7T 脑肿瘤成像的快速靶向光谱成像

• 批准号: 9767810
• 负责人: Hoby P Hetherington
• 金额: $ 44.57万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9767810
• 关键词: 3-Dimensional; Acceleration; Address; Brain; Brain Chemistry; Brain Neoplasms; Brain imaging; Brain region; Chemicals; Childhood Glioma; Choline; Clinical; Clinical Management; Complement; Complex; Data; Development; Diagnosis; Diagnostic; Diffusion; Dimensions; Epilepsy; Evaluation; Glioblastoma; Goals; Image; Immune response; Immunotherapeutic agent; Immunotherapy; Inositol; Lipids; Location; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Medical; Metabolic; Methods; Monitor; Morphologic artifacts; Multiple Sclerosis; Nature; Operative Surgical Procedures; Patients; Performance; Physiologic pulse; Physiology; Process; Property; Recovery; Recurrence; Regimen; Relaxation; Research Personnel; Resolution; Sampling; Scanning; Slice; Therapeutic; Time; Tissues; Translating; Traumatic Brain Injury; Update; Water; Work; anatomic imaging; base; cancer imaging; chemoradiation; clinical application; clinically relevant; contrast enhanced; cost; effective therapy; experience; follow-up; imaging approach; imaging modality; imaging study; improved; ineffective therapies; magnetic field; magnetic resonance spectroscopic imaging; neuro-oncology; novel therapeutic intervention; premature; preservation; research clinical testing; response; spectroscopic imaging; success; treatment effect; treatment response; tumor; tumor metabolism; tumor progression; two-dimensional

Magnetic Resonance Spectroscopic Imaging (MRSI) has proven to provide unique information for the diagnosis and management of brain tumors, epilepsy, multiple sclerosis and traumatic brain injury. Despite the obvious advantage of imaging approaches over single volume measurements, clinically, most MRS studies are still performed as single voxel studies. The reluctance to include MRSI in clinical evaluations arises primarily from four factors: 1) increased acquisition times; 2) limitations in spectral quality when data is acquired over larger brain regions; 3) limitations in SNR and 4) challenges in sampling the cortical periphery. To overcome these limitations we will develop a fast MRSI method (5-10min.) which uses: 1) two dimensional rosette encoding trajectories to rapidly sample the brain in two dimensions while minimizing gradient demands and improve spectral quality; 2) Hadamard encoding in the third dimension to minimize localization artifacts and provide excellent slice profiles for smaller numbers of partitions (4-8) covering the most relevant brain region; 3) a high degree shim insert to maximize magnetic field homogeneity and improve spectral quality and 4) dynamic spatially selective dephasing to maximize SNR and sample the cortical periphery. Consistent with what is the most widely accepted MRS clinical application currently, we will evaluate the methods in patients with high-grade brain tumors receiving immunotherapy. Although immunotherapy is a highly promising new therapeutic approach for brain tumors, treatment effects can mimic tumor progression on conventional MRI, compromising our ability to effectively monitor and manage these patients. MRSI offers an alternative means to monitor progression, based on tumor metabolism and physiology as opposed to relaxation properties of tissue water (conventional MRI). Thus we believe that MRSI may provide additive values and significantly aid in the management of these patients. This work will be performed at 3T and 7T.

磁共振波谱成像（MRSI）已被证明可以提供独特的信息， 脑肿瘤、癫痫、多发性硬化症和脑外伤的诊断和治疗。尽管 成像方法明显优于单次容积测量，临床上，大多数MRS研究 仍然作为单体素研究进行。不愿将MRSI纳入临床评价的主要原因是 四个因素：1）采集时间增加; 2）在数据采集时间超过 更大的大脑区域; 3）SNR的限制和4）对皮层周边进行采样的挑战。克服 针对这些局限性，我们将开发一种快速MRSI方法（5- 10分钟）。其使用：1）二维玫瑰花结 编码轨迹以在两个维度上快速对大脑进行采样，同时最小化梯度需求， 改善频谱质量; 2）第三维中的Hadamard编码，以最小化定位伪影，以及 - 为覆盖最相关的脑区域的较少数量的分区（4-8）提供优异的切片轮廓; 3)高度垫片插入，以最大限度地提高磁场均匀性并提高光谱质量和4） 动态空间选择性去相位以最大化SNR并对皮质周边进行采样。符合 目前最广泛接受的MRS临床应用是什么，我们将在患者中评估这些方法 接受免疫治疗的高级别脑肿瘤。虽然免疫疗法是一种非常有前途的新方法， 脑肿瘤的治疗方法，治疗效果可以在常规MRI上模拟肿瘤进展， 从而影响了我们有效监控和管理这些患者的能力。MRSI提供了一种替代方法， 监测进展，基于肿瘤代谢和生理学，而不是组织的松弛特性 水（常规MRI）。因此，我们认为MRSI可以提供附加值，并显著有助于 管理这些病人。该工作将在3 T和7 T下进行。