Cancer Prevention: Staging my career as a cancer biologist

黑色素瘤是最致命的皮肤癌，由于治疗失败，发病率逐年上升，预后差。 一级预防战略和二级预防战略。黑色素瘤的治疗策略通常是 由于患者的内在或获得性耐药性而未获成功，突出了对新的、继发性的 具有经过充分验证的机械性目标的预防-干预战略。因此，我的职业目标是 成为一名独立的、学术上的黑色素瘤研究人员，专注于翻译科学的发展 针对黑色素瘤的策略。为了确保这一结果，所附的全面研究、指导和 职业发展计划将在博士后和博士后研究员期间实施 训练期。 我的总体假设是，以目标为导向的研究和职业发展在我的博士前和 博士后多年的培训将使我成为一名独立的、学术上的黑色素瘤患者 研究员。以下目标将解决这一假设： 目标1：本论文的研究项目--目标、理论基础、假设和目前的进展。 目标2：论文研究项目--待完成的工作。 目标3：博士后研究方向。 我的博士前研究很有意义，因为它提供了关于不同角色的关键知识 氧化应激、自噬和p62调控作为黑色素瘤发生和发展的生存机制 黑色素瘤靶向治疗的潜力。此外，在研究期间获得的研究技术技能 博士后阶段将对我的博士后研究培训产生积极影响，因为我学会了评估 黑色素瘤的发展，预防策略和体内靶向治疗。我提出的建议的结果 研究还将通过制定治疗策略对公共卫生产生积极影响 黑色素瘤。拟议的职业发展计划将有助于我成为博士后研究员 以及随后过渡到研究教员的职位。总体而言，概述的两阶段研究金培训 计划无疑将有助于我的研究和职业发展，因为我将继续为改进做出贡献 公共卫生作为一名公认的转化型癌症研究人员。

Melanoma is the deadliest skin cancer with yearly increasing incidence and poor prognosis due to failure of both primary and secondary prevention strategies, respectively. Melanoma treatment strategies are often unsuccessful due to patients’ intrinsic or acquired drug resistance, highlighting the need for novel, secondary prevention-intervention strategies with thoroughly validated mechanistic targets. Therefore, my career goal is to become an independent, academic melanoma researcher, with a focus in translational science to develop strategies to target melanoma. To ensure this outcome, the enclosed comprehensive research, mentoring, and career development plans will be implemented over the course of the predoctoral and postdoctoral fellowship training periods. My overall hypothesis is that goal-oriented research and career development in my predoctoral and postdoctoral training years will lead me to establish myself as an independent, academic melanoma researcher. The following aims will address this hypothesis: Aim 1: The Dissertation Research Project – goal, rationale, hypotheses, and progress thus far. Aim 2: The Dissertation Research Project – work to be completed. Aim 3: The Postdoctoral Research Direction. My predoctoral research is significant because it provides critical knowledge about the differential role of oxidative stress, autophagy, and p62 regulation as survival mechanisms for melanoma development and the potential for therapeutic targeting in melanoma. Further, the research technical skills acquired during the predoctoral phase will positively impact my postdoctoral research training as I learn to evaluate mechanisms of melanoma development, prevention strategies and therapeutic targeting in vivo. The results of my proposed research studies will also positively impact public health by development of therapeutic strategies for melanoma. The proposed career development plan will be instrumental for my training as a postdoctoral fellow and subsequent transition to a research faculty position. Overall, the outlined dual-phase fellowship training plan will undoubtedly facilitate my research and career development as I continue to contribute to improving public health as an established translational cancer researcher.