CD40 regulation of acute virus infection

CD40信号在增强获得性免疫的发展和维持方面得到了很好的证实。然而，CD40信号在先天性免疫反应中的作用研究较少，目前还没有认识到CD40信号在快速控制急性病毒感染中的重要作用。在这里，我们提供了强有力的初步发现，CD40信号对于早期刺激腹膜巨噬细胞的天然免疫途径至关重要，从而控制急性病毒感染。在这些拟议的研究中，我们将使用埃博拉病毒和EBOV的BSL2模型病毒来确定保护所需的CD40+细胞间隔(S)，并了解使用CD40信号来控制埃博拉病毒感染的细胞群体的广度。对这些细胞群体的阐明将阐明可导致治疗干预的有针对性的方法。

CD40 signaling is well established to enhance development and maintenance of adaptive immunity. However, the role of CD40 signaling during innate immune responses is more poorly studied and an important role for CD40 signaling in rapid control of acute virus infections is not currently appreciated. Here, we provide strong preliminary findings that CD40 signaling is critical for early stimulation of innate immune pathways in peritoneal macrophages, resulting in control of acute viral infection. In these proposed studies, we will use both Ebola virus (EBOV) and a BSL2 model virus of EBOV to identify the CD40+ cellular compartment(s) required for protection and understand the breadth of cell populations that use CD40 signaling to control EBOV infection. Elucidation of these cell populations will elucidate targeted approaches that can lead to therapeutic interventions.