Role of circadian rhythms in the susceptibility to Clostridium difficile infection

昼夜节律在艰难梭菌感染易感性中的作用

基本信息

  • 批准号:
    9895923
  • 负责人:
  • 金额:
    $ 21.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-01-31 至 2021-12-31
  • 项目状态:
    已结题

项目摘要

Project Summary Clostridium difficile is now the most common cause of hospital-acquired infections in the United States. This Gram-positive, spore-forming, strict anaerobe most commonly infects antibiotic- treated hosts, though community-acquired infections are on the rise for unknown reasons. To survive outside a host, C. difficile produces dormant spores. Spores are metabolically dormant forms of bacteria that are resistant to many harsh conditions (e.g., many cleaning agents, heat, radiation and antibiotics). In a host, C. difficile spores germinate in response to bile acids. Following C. difficile spore germination, the vegetative cells produce the toxins that trigger the host’s inflammatory response and that cause the primary symptoms of disease. Remarkably, the effectors of C. difficile infection (e.g., toxin receptor abundance and inflammation) exhibit strong circadian rhythms. These rhythms are generated by molecular circadian clocks found in virtually every mammalian cell, and which rely on transcriptional feedback loops to coordinate the rhythmic expression of about 10-15% of the genome. The circadian nature of the host physiology suggests that the normal host circadian rhythms may impact the efficiency with which C. difficile infects, colonizes and causes disease. In this exploratory application, the effects of host circadian biology on the ability of C. difficile to colonize and on the host’s inflammatory response to C. difficile infection will be explored.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jerome Menet其他文献

Jerome Menet的其他文献

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{{ truncateString('Jerome Menet', 18)}}的其他基金

Cooperation between transcription factors and its role in the regulation of rhythmic enhancer activity by the circadian clock
转录因子之间的合作及其在生物钟调节节律增强子活性中的作用
  • 批准号:
    10650845
  • 财政年份:
    2022
  • 资助金额:
    $ 21.59万
  • 项目类别:
Regulation of circadian physiology by rhythmic food intake and the mTOR pathway
通过有节律的食物摄入和 mTOR 通路调节昼夜节律生理学
  • 批准号:
    10367363
  • 财政年份:
    2022
  • 资助金额:
    $ 21.59万
  • 项目类别:
Cooperation between transcription factors and its role in the regulation of rhythmic enhancer activity by the circadian clock
转录因子之间的合作及其在生物钟调节节律增强子活性中的作用
  • 批准号:
    10420343
  • 财政年份:
    2022
  • 资助金额:
    $ 21.59万
  • 项目类别:
Regulation of circadian physiology by rhythmic food intake and the mTOR pathway
通过有节律的食物摄入和 mTOR 通路调节昼夜节律生理学
  • 批准号:
    10579228
  • 财政年份:
    2022
  • 资助金额:
    $ 21.59万
  • 项目类别:
Role of circadian rhythms in the susceptibility to Clostridium difficile infection
昼夜节律在艰难梭菌感染易感性中的作用
  • 批准号:
    10092927
  • 财政年份:
    2020
  • 资助金额:
    $ 21.59万
  • 项目类别:
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