Neural mechanisms of nausea, vomiting, and energy balance dysregulation in animal models

动物模型中恶心、呕吐和能量平衡失调的神经机制

基本信息

  • 批准号:
    9895765
  • 负责人:
  • 金额:
    $ 36.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-04-01 至 2022-03-31
  • 项目状态:
    已结题

项目摘要

Project Summary Nausea, vomiting, and anorexia are common side effects of enumerable therapeutic drugs, diseases, and disease treatments. An extreme example of this is emetogenic chemotherapy (EC)-induced nausea and vomiting (CINV) and energy balance dysregulation, which devastate quality of life and obviate treatment adherence. Strikingly, complete control of CINV and energy balance dysregulation has not been achieved, despite the fact that an estimated 650,000 cancer patients undergo chemotherapy each year. The neural circuits that are engaged by chemotherapy to produce CINV and energy balance dysregulation remain elusive. Recent data identify a circuit of EC-activated nucleus tractus solitarius (NTS) neurons that project to the lateral parabrachial nucleus (lPBN), and EC-activated lPBN neurons that project to the central nucleus of the amygdala (CeA) in the rat. Further results indicate that CeA glutamate receptor signaling, potentially via the lPBN→CeA projection, is necessary for the full expression of EC-induced pica (a validated rodent model of nausea/malaise), anorexia, and weight loss. Though these data begin to outline a circuit of CNS sites through which EC-induced malaise and anorexia are mediated, important details of the circuit remain unknown. Specifically, the functional relevance, neurochemical phenotypes, modulatory inputs, and target projections of these hindbrain-forebrain neural populations must be directly investigated to uncover novel targets for the treatment of CINV and energy balance dysregulation. To this end, the innovative approaches in this proposal combine state-of-the-art neuroscience techniques to [1] investigate the functional role of projection- and cell type-specific neuron populations in the mediation of CINV and energy dysregulation, [2] examine the neuropeptide/signaling phenotype(s) and post-synaptic targets of EC-activated CeA neurons, and [3] examine the modulatory role of central GLP-1 signaling in the NTS, lPBN, and CeA in CINV and energy dysregulation. The proposed experiments will use and compare non-vomiting and vomiting laboratory animal models to maximize translational potential of this work. Overall, these studies will expand our understanding of the mechanisms mediating chemotherapy-induced malaise and energy balance dysregulation by revealing the neurocircuitry and chemical signals that produce these undesirable side effects. Additionally, results will identify new target neuron populations and/or neurochemical/peptide systems for the development of novel treatments of CINV and energy balance dysregulation.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Bart C DE JONGHE其他文献

Bart C DE JONGHE的其他文献

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{{ truncateString('Bart C DE JONGHE', 18)}}的其他基金

Targeting the GDF15-GFRAL system to treat nausea and emesis
靶向 GDF15-GFRAL 系统治疗恶心和呕吐
  • 批准号:
    10463832
  • 财政年份:
    2021
  • 资助金额:
    $ 36.19万
  • 项目类别:
Second generation GLP-1 agonists without nausea/emesis side effects
第二代 GLP-1 激动剂,无恶心/呕吐副作用
  • 批准号:
    10183954
  • 财政年份:
    2021
  • 资助金额:
    $ 36.19万
  • 项目类别:
Targeting the GDF15-GFRAL system to treat nausea and emesis
靶向 GDF15-GFRAL 系统治疗恶心和呕吐
  • 批准号:
    10630836
  • 财政年份:
    2021
  • 资助金额:
    $ 36.19万
  • 项目类别:
Targeting the GDF15-GFRAL system to treat nausea and emesis
靶向 GDF15-GFRAL 系统治疗恶心和呕吐
  • 批准号:
    10312414
  • 财政年份:
    2021
  • 资助金额:
    $ 36.19万
  • 项目类别:
Second generation GLP-1 agonists without nausea/emesis side effects
第二代 GLP-1 激动剂,无恶心/呕吐副作用
  • 批准号:
    10577892
  • 财政年份:
    2021
  • 资助金额:
    $ 36.19万
  • 项目类别:
Second generation GLP-1 agonists without nausea/emesis side effects
第二代 GLP-1 激动剂,无恶心/呕吐副作用
  • 批准号:
    10357951
  • 财政年份:
    2021
  • 资助金额:
    $ 36.19万
  • 项目类别:
Neural Mechanisms of Nausea, Vomiting, and Energy Dysregulation
恶心、呕吐和能量失调的神经机制
  • 批准号:
    10752271
  • 财政年份:
    2017
  • 资助金额:
    $ 36.19万
  • 项目类别:
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