Prehabilitation of Frail Surgical Cancer Patients using Remote Ischemic Preconditioning
使用远程缺血预处理对体弱的外科癌症患者进行预康复
基本信息
- 批准号:9896751
- 负责人:
- 金额:$ 20.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAdherenceAdvanced Malignant NeoplasmAgeAnimal ModelAthleticBlood PressureBlood VesselsBlood flowCancer PatientCardiovascular PhysiologyCardiovascular systemClinicalClinical TrialsColon CarcinomaControl GroupsDataElderlyEndotheliumEnrollmentEquipmentExcisionExerciseExhibitsExtensorFatigueFrail ElderlyFutureHealthcare SystemsHome environmentHourHumanIndividualInterventionIschemiaIschemic PreconditioningKneeLaboratoriesLegLength of StayLimb structureLiteratureMalignant NeoplasmsMeasuresMorbidity - disease rateMulti-Institutional Clinical TrialMuscleMuscle FatigueMuscle functionNeoadjuvant TherapyNeurologicOperative Surgical ProceduresOrganOutcome StudyOutputParesisParticipantPatient CarePatient-Focused OutcomesPatientsPerformancePerfusionPerioperativePhasePhysical FitnessPhysical FunctionPhysical activityPhysiologicalPopulationPostoperative ComplicationsPostoperative PeriodPreoperative CareRandomizedRecoveryRecovery of FunctionRehabilitation therapyResistanceRiskRunningScheduleSingle-Blind StudySiteSkeletal MuscleStimulusStressSystolic PressureTechniquesTestingTimeTissuesWalkingWorkagedaging populationarmattenuationblood pressure variabilitycardioprotectionchemotherapychronic strokecohortcolon cancer patientscomorbiditycost effectivedisabilityefficacy testingexercise regimenfrailtyimprovedintervention costischemic injurylimb ischemiametermortalitymotor function improvementmotor learningmuscle strengthnegative affectolder patientpatient populationpostoperative recoveryprogramsprospectiveresponsesecondary outcomesedentarystandard of carestroke survivorsurgery outcomesurgical riskwalking speed
项目摘要
Remote ischemic preconditioning (RIPC) was first described three decades ago as an intervention to protect
vital organs from ischemic injury. RIPC occurs when a tissue is made transiently ischemic (5 minutes) for
repeated bouts (5 times) prior to the longer ischemic insult. Recently it has been shown exercise performance
and motor function are improved in young, healthy individuals when RIPC is performed on the arm or leg using
a simple blood pressure cuff to occlude blood flow to the limb. The application of RIPC to individuals with reduced
functional capacity, however, is largely unexplored. Our group was the first to apply RIPC to chronic stroke
survivors with reduced physical function, and two weeks of RIPC increases walking speed, paretic muscle
strength and fatigue resistance. Advanced age and cancer are both dramatic accelerators of frailty and frail
patients have poor surgical outcomes. Therefore, we propose to apply this non-invasive, simple intervention as
a “prehabiliative” therapy to elderly patients with colon cancer during the perioperative period. We will enroll 96
colon cancer patients aged 55-85 who are ≥17 days prior to scheduled curative resection of colon cancer. After
study enrollment, all participants will perform the six-minute walk test as a measure of frailty. Participants will
then be randomized to receive either RIPC on their upper, non-dominant arm daily for 14 days prior to surgery,
or to receive standard of care (no intervention). After 14 days of either RIPC or no intervention, the 6-minute
walk test will be re-assessed within 48 hours of surgery. Our primary study outcome will be the difference in six-
minute walk distance (in meters) between patients in the RIPC group vs. those in the standard of care group
following the two-week pre-operative intervention period (Aim 1). We hypothesize that patients in the RIPC
group will walk further during the six-minute walk test than those in the standard of care group due to the well-
defined effects of RIPC to improve athletic performance, cardiovascular function, and strength in healthy
individuals. A secondary study outcome will be the difference in six-minute walk test distance between the RIPC
and standard of care group 4-weeks postoperatively (Aim 2). We hypothesize that patients in the RIPC group
will have more rapid recovery from surgery, which would be evidenced by increased walking endurance post-
operatively. Another secondary study outcome will be the amount of intraoperative blood pressure variability
(time systolic pressure is above or below 135 mmHg or 95 mmHg, respectively) between the RIPC and control
groups (Aim 3). We hypothesize that RIPC will reduce intraoperative blood pressure variability due to the well
described effects of RIPC to improve systemic vascular function. Future larger studies will examine the effects
of RIPC prehabilitation on surgical outcomes such as length of hospital stay and all-cause mortality in frail, elderly
patients with colon cancer as well as other patient cohorts with reduced functional capacity.
远端缺血预处理(RIPC)在30年前首次被描述为一种保护
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Matthew Durand其他文献
Matthew Durand的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Matthew Durand', 18)}}的其他基金
Blood Flow Regulation and Neuromuscular Function Post-Stroke
中风后的血流调节和神经肌肉功能
- 批准号:
10751266 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Ischemic Conditioning and Improved Motor Function Post Stroke
缺血调理和改善中风后运动功能
- 批准号:
10448267 - 财政年份:2019
- 资助金额:
$ 20.7万 - 项目类别:
Ischemic Conditioning and Improved Motor Function Post Stroke
缺血调理和改善中风后运动功能
- 批准号:
10219318 - 财政年份:2019
- 资助金额:
$ 20.7万 - 项目类别:
Ischemic Conditioning and Improved Motor Function Post Stroke
缺血调理和改善中风后运动功能
- 批准号:
9974556 - 财政年份:2019
- 资助金额:
$ 20.7万 - 项目类别:
Ischemic Conditioning and Improved Motor Function Post Stroke
缺血调理和改善中风后运动功能
- 批准号:
10650390 - 财政年份:2019
- 资助金额:
$ 20.7万 - 项目类别:
Ischemic Conditioning and Improved Motor Function Post Stroke
缺血调理和改善中风后运动功能
- 批准号:
9803461 - 财政年份:2019
- 资助金额:
$ 20.7万 - 项目类别:
相似海外基金
An innovative, AI-driven prehabilitation platform that increases adherence, enhances post-treatment outcomes by at least 50%, and provides cost savings of 95%.
%20创新、%20AI驱动%20康复%20平台%20%20增加%20依从性、%20增强%20治疗后%20结果%20by%20at%20至少%2050%、%20和%20提供%20成本%20节省%20of%2095%
- 批准号:
10057526 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Grant for R&D
Improving Repositioning Adherence in Home Care: Supporting Pressure Injury Care and Prevention
提高家庭护理中的重新定位依从性:支持压力损伤护理和预防
- 批准号:
490105 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Operating Grants
I-Corps: Medication Adherence System
I-Corps:药物依从性系统
- 批准号:
2325465 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Standard Grant
Unintrusive Pediatric Logging Orthotic Adherence Device: UPLOAD
非侵入式儿科记录矫形器粘附装置:上传
- 批准号:
10821172 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk
Nuestro Sueno:夫妻干预措施的文化适应,以改善拉丁裔夫妇的 PAP 依从性和睡眠健康,对阿尔茨海默病风险产生影响
- 批准号:
10766947 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
CO-LEADER: Intervention to Improve Patient-Provider Communication and Medication Adherence among Patients with Systemic Lupus Erythematosus
共同领导者:改善系统性红斑狼疮患者的医患沟通和药物依从性的干预措施
- 批准号:
10772887 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
- 批准号:
10594350 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
病毒抑制的艾滋病毒和中风患者的抗逆转录病毒治疗依从性和探索性蛋白质组学
- 批准号:
10748465 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Improving medication adherence and disease control for patients with multimorbidity: the role of price transparency tools
提高多病患者的药物依从性和疾病控制:价格透明度工具的作用
- 批准号:
10591441 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Development and implementation of peer-facilitated decision-making and referral support to increase uptake and adherence to HIV pre-exposure prophylaxis in African Caribbean and Black communities in Ontario
制定和实施同行协助决策和转介支持,以提高非洲加勒比地区和安大略省黑人社区对艾滋病毒暴露前预防的接受和依从性
- 批准号:
491109 - 财政年份:2023
- 资助金额:
$ 20.7万 - 项目类别:
Fellowship Programs














{{item.name}}会员




