Catalytic postgraduate research training in HIV disease monitoring its treatments and comorbidities in Namibia

艾滋病毒流行病继续对撒哈拉以南非洲和纳米比亚产生重大影响; 尽管艾滋病病毒在过去十年中一直在缓慢下降，但流行率仍约为17% 需要作出更大的努力来实现消除。尝试更快的消除 受到许多因素的阻碍，包括延误诊断，由于 误诊或延误诊断，治疗监测不良，结核病和其他疾病的合并感染 共病和医疗保健提供差以及随之而来的患者不依从。虽然一个伟大的 大量的研究致力于调查这些艾滋病毒相关的问题，有必要 现在在纳米比亚进行更多的研究。 我们申请的规划补助金将加快确定最佳方法的过程， 纳米比亚大学健康科学学院的设置， 围绕四个科学重点领域开展艾滋病毒研究培训。具体而言，这些重点领域是： 1.基于艾滋病毒/结核基因型的耐药性监测（公共卫生监测） 2.基于药物警戒的抗逆转录病毒药物不良反应监测 （公共卫生监测） 3.对用于治疗艾滋病毒和相关合并感染的药物进行治疗药物监测 （艾滋病毒治疗监测） 4.监测治疗期间患者的行为（依从性）及其医疗护理（治疗 艾滋病毒监测） 在现阶段，设想纳米比亚大学将开发和提供以下方面的培训： 通过为期2年的全日制硕士课程进行艾滋病毒研究，该课程将包括 第一年，第二年进行研究。第一年的教学培训 就我们设想的培训方法进行的研究将涉及更一般的领域，包括研究 方法论、科学交流和人类受试者保护 科学主题领域。在培训的第二年，四个重点领域之一 将成为他们研究项目的一部分预计这一办法将提供广泛的基础， 艾滋病毒相关研究方法的培训以及特定领域的研究科学产出 可以在本地支持的域。规划补助金将是提供支持的基础 这次训练的计划

The HIV epidemic continues to have major impact on sub-Saharan Africa and Namibia specifically; while HIV has been decreasing slowly over the last decade, prevalence is still approximately 17% and a much greater effort is required to work towards elimination. Attempts at faster elimination are thwarted by a number of factors including delayed diagnosis, inappropriate treatment due to mis- or delayed diagnosis, poor treatment monitoring, co-infection of tuberculosis (TB) and other comorbidities, and poor healthcare provision and consequent patient non-adherence. Though a great volume of research is dedicated to the investigation of these HIV-related issues, there is a need now to undertake greater research in the context of Namibia. The planning grant we apply for will expedite the process of determining the best approach within the setting of the University of Namibia Faculty of Health Sciences to implementing a postgraduate training in HIV research around four scientific focus areas. Specifically, these focus areas are: 1. HIV/TB genotype-based drug resistance surveillance (public health monitoring) 2. Pharmacovigilance-based monitoring of antiretroviral agents causing adverse drug reactions (public health monitoring) 3. Therapeutic drug monitoring of medicines used in the treatment of HIV and related co-infections (treatment monitoring of HIV) 4. Monitoring of patient behavior (adherence) during treatment and their medical care (treatment monitoring of HIV) At this stage it is envisaged that the University of Namibia will develop and provide training in HIV research through a 2-year full-time Masters-level program that will include a taught element in the first year and a research project in the second year. Didactic training in the first year of study towards our envisaged training approach will address more general areas including research methodology, scientific communication, and human subjects protection in addition to the four scientific subject areas. In the second year of the training, one aspect of the four focus areas will form part of their research project. This approach is expected to provide a broad base training in HIV-related research approaches as well as research scientific output in a specific domain that can be supported locally. The planning grant will be fundamental in providing support to the planning of this training.