Development and assessment of population specific fetal growth references
Development and assessment of population specific fetal growth references
批准号:
9768506
负责人:
Nicola Hawley
金额:
$8.58万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-08-25 至 2021-01-31
关键词:
AdultAge-MonthsBiological MarkersBiometryCardiovascular DiseasesCesarean sectionChildChronic DiseaseClinicalCommunitiesDataDetectionDevelopmentDiabetes MellitusDiagnosticDiagnostic testsEthnic OriginEthnic groupFailureFetal GrowthFetal Growth RetardationFoundationsGenerationsGoldGrowthHealthHigh birth weight infantInfantInfant MortalityInterventionLeftLow Birth Weight InfantMeasurementMeasuresMetabolicMethodsModelingMorbidity - disease rateMothersNative HawaiianNeonatalNeonatal MortalityNot Hispanic or LatinoObesityOdds RatioOutcomeOverweightPacific Island AmericansPerformancePerinatalPopulationPopulation GroupPregnancyPremature BirthPrenatal carePrevalencePreventive InterventionPublic HealthPublishingRiskSamoanSamplingSampling StudiesTestingTimeUltrasonographyUnderrepresented PopulationsVariantWomanWorld Health Organizationbasecardiometabolic riskclinical caredesignearly detection biomarkersfetalimprovedinfancyinnovationmaternal morbiditymortalityneonatal morbidityneonatal outcomeobesity biomarkersobesity in childrenobesity riskperinatal outcomespostnatalpotential biomarkerpregnantrapid infant weight gain
中文摘要
最佳的胎儿生长被认为是终身健康的基础;两种生长限制
英文摘要
Optimal fetal growth is recognized as the basic foundation for lifelong health; both growth restriction
and excess fetal growth are associated with infant, child, and adult morbidity and mortality. Identifying
abnormal fetal growth early enough to allow for clinical intervention and mitigation of the associated maternal
and neonatal risk depends on the availability of appropriate growth charts with which to compare fetal biometric
measurements. There have been two recently published fetal growth standards (designed to represent optimal
growth); one by INTERGROWTH-21st and another by the World Health Organization (WHO). Questions have
been raised, however, about their applicability and clinical utility for all population groups based on marked
variation in fetal growth according to ethnicity and the creation of the standards using measurements from
healthy women, in optimal conditions, who may be unrepresentative of the broader pregnant population.
Responding to this debate, this proposal aims to develop fetal growth references for Samoans, which reflect
usual growth and may therefore avoid some of the potential misclassification of both growth restriction and
excess fetal growth associated with the standards. Until now, Pacific Islanders, including Samoans, have been
extremely underrepresented in the construction of publicly available growth charts despite their markedly
poorer perinatal outcomes compared with the general US population.
Our specific aims are: (1) to develop and validate population-specific growth references for Samoans;
(2) to (a) compare the Samoan-specific fetal growth references against the WHO and INTERGROWTH-21st
standards and (b) explain any systematic differences between growth charts; and (3) to compare the
diagnostic ability of the Samoan-specific fetal growth references against the WHO and INTERGROWTH-21st
standards for perinatal and childhood obesity outcomes.
The innovation in this proposal lies in our focus on a Pacific Islander population, the fact that we will be
among the first to test the diagnostic and predictive ability of the very recently published WHO standards in a
traditionally underrepresented population group, and our focus on predicting both perinatal and childhood-
obesity related outcomes using fetal growth references. While the connection between fetal growth and later
cardiometabolic risk is well established, few studies have explored the utility of fetal growth trajectories as a
potential biomarker for later metabolic risk. We expect the construction of an ethnicity-specific fetal growth
reference to improve clinical detection of fetal growth abnormalities, allow earlier management, and therefore
improve perinatal outcomes among Samoans. In addition, increased detection of childhood-obesity risk,
allowing for early preventative intervention, stands to have a significant public health impact for this population.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Preterm birth among Pacific Islander women and related perinatal outcomes: a scoping review protocol.
太平洋岛民妇女和相关围产期结局的早产:范围审查方案。
DOI:
10.1136/bmjopen-2021-050483
发表时间:
2021-11-02
期刊:
BMJ open
影响因子:
2.9
作者:
[Wu B, Arslanian KJ, Nyhan K, Taylor S, Shabanova V, Muasau-Howard B, Hawley NL]
通讯作者:
Hawley NL
An Adolescent-mediated intervention to improve diabetes prevention and management in Pacific Islander Families
-
批准号:10582224
-
项目类别:
-
资助金额:$2.87万
-
财政年份:2022
-
负责人:Nicola Hawley
-
依托单位:
An Adolescent-mediated intervention to improve diabetes prevention and management in Pacific Islander Families
-
批准号:10693262
-
项目类别:
-
资助金额:$32.67万
-
财政年份:2021
-
负责人:Nicola Hawley
-
依托单位:
An Adolescent-mediated intervention to improve diabetes prevention and management in Pacific Islander Families
-
批准号:10713399
-
项目类别:
-
资助金额:$6.17万
-
财政年份:2021
-
负责人:Nicola Hawley
-
依托单位:
An Adolescent-mediated intervention to improve diabetes prevention and management in Pacific Islander Families
-
批准号:10491341
-
项目类别:
-
资助金额:$32.93万
-
财政年份:2021
-
负责人:Nicola Hawley
-
依托单位:
An Adolescent-mediated intervention to improve diabetes prevention and management in Pacific Islander Families
-
批准号:10367592
-
项目类别:
-
资助金额:$35.9万
-
财政年份:2021
-
负责人:Nicola Hawley
-
依托单位:
An Adolescent-mediated intervention to improve diabetes prevention and management in Pacific Islander Families
-
批准号:10617935
-
项目类别:
-
资助金额:$9.3万
-
财政年份:2021
-
负责人:Nicola Hawley
-
依托单位: