A Secondary Analysis to Identify HPV Vaccination Disparities across Hispanic Subgroups in the United States

确定美国西班牙裔亚群体 HPV 疫苗接种差异的二次分析

• 批准号: 9768550
• 负责人: Paul L Reiter
• 金额: $ 19.5万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-22 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9768550
• 关键词: Accounting; Address; Adolescent; Adolescent and Young Adult; Age; Central American; Child; Country; County; Cuban; Data; Data Analyses; Data Reporting; Development; Dominican; Dose; Ethnic group; Evaluation; Goals; Gold; Health; Health Planning; Health Promotion; Health behavior outcomes; Healthcare; Hispanics; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus infection; Immigration; Immunization; Incidence; Individual; Intervention; Knowledge; Language; Laws; Malignant neoplasm of cervix uteri; Masks; Mexican; Mexican Americans; Outcome; Parents; Persons; Population Heterogeneity; Provider; Public Health; Puerto Rican; Recommendation; Recording of previous events; Reporting; Research; Sample Size; Sampling; Series; Services; South American; Subgroup; Surveys; Teenagers; United States; Vaccinated; Vaccination; Vaccine Research; Vaccines; Woman; base; cost; demographics; epidemiologic data; ethnic minority population; experience; health care availability; improved; novel; programs; racial and ethnic; secondary analysis; side effect; vaccine trial

PROJECT SUMMARY: Hispanics are the largest racial/ethnic minority population in the United States (US) and experience several disparities related to human papillomavirus (HPV), including Hispanic women having the highest cervical cancer incidence rate of any racial/ethnic group in the country. HPV vaccine is recommended for adolescents and young adults in the US, and estimates of HPV vaccine coverage among Hispanic adolescents vary, though recent national data suggest that vaccine coverage is similar to or slightly higher than other racial/ethnic groups. However, a key and recurring limitation of existing HPV vaccine research is that Hispanics have been aggregated and examined as a single, homogeneous group in analyses. Hispanics are in fact a heterogeneous population, with the term “Hispanic” referring to persons of Mexican, Cuban, Puerto Rican, Dominican, Central American, South American, or other Spanish descent. There are striking differences between these Hispanic subgroups on immigration histories, demographics, and health behaviors and outcomes, and aggregating them in past HPV vaccine research has likely masked important subgroup differences. Unmasking and accounting for these subgroup disparities is an important component of planning health promotion programs for Hispanics (e.g., HPV vaccine interventions and surveillance efforts). Our long-term goal is to understand how HPV vaccination outcomes differ across Hispanic subgroups and then apply this understanding to increase vaccine coverage. The proposed study will take the first step in achieving this goal by analyzing existing data from the 2012-2016 National Immunization Survey-Teen (NIS-Teen) to identify existing HPV vaccination disparities across Hispanic subgroups. The NIS-Teen is considered the gold standard of US vaccination data, and analyses will include a large, national sample of Hispanic adolescents (n=16,381) and be well-powered to identify subgroup disparities. The proposed study will determine how Hispanic subgroups differ in terms of current HPV vaccine coverage among adolescents (Aim 1), multi-level correlates of HPV vaccine coverage (Aim 2), potential barriers to parents vaccinating their children against HPV (Aim 3), and the validity of parent-reported HPV vaccination data (Aim 4). Each study aim will address a unique research question and together will provide a novel and comprehensive understanding of how HPV vaccination outcomes differ across Hispanic subgroups. We anticipate that Hispanic subgroup differences will be identified within each study aim. The resulting subgroup-specific data will greatly impact both the development (i.e., current HPV vaccine coverage, correlates, and barriers) and evaluation (i.e., validity of parent-reported data) of HPV vaccine interventions and surveillance efforts for Hispanics.

项目概要： 西班牙裔是美国最大的种族/少数民族人口， 与人乳头瘤病毒（HPV）有关的差异，包括西班牙裔妇女的宫颈癌发生率最高， 全国任何种族/族裔群体的癌症发病率。建议青少年接种HPV疫苗 和年轻的成年人在美国，和估计的HPV疫苗覆盖率在西班牙裔青少年不同， 尽管最近的国家数据表明，疫苗覆盖率与其他国家相似或略高， 种族/民族团体。然而，现有HPV疫苗研究的一个关键和反复出现的限制是， 在分析中被汇总并作为一个单一的同质组进行检查。西班牙裔实际上是 异质人口，“西班牙裔”一词指的是墨西哥人、古巴人、波多黎各人， 多米尼加，中美洲，南美洲或其他西班牙血统。有着惊人的差异 在移民历史、人口统计学和健康行为方面， 结果，并在过去的HPV疫苗研究中汇总它们可能掩盖了重要的亚组 差异揭示和说明这些亚组差异是规划的一个重要组成部分 西班牙裔美国人的健康促进计划（例如，HPV疫苗干预和监测工作）。 我们的长期目标是了解HPV疫苗接种结果在西班牙裔亚组之间的差异， 应用这种理解来增加疫苗覆盖率。拟议的研究将迈出第一步， 通过分析2012-2016年全国青少年免疫调查（NIS-Teen）的现有数据， 确定西班牙裔亚组之间现有的HPV疫苗接种差异。NIS-Teen被认为是 美国疫苗接种数据标准，分析将包括西班牙裔青少年的大型全国样本 （n= 16，381），并具有良好的把握度来识别亚组差异。这项拟议的研究将确定如何 西班牙裔亚组在目前青少年HPV疫苗覆盖率方面存在差异（Aim 1），多水平 HPV疫苗覆盖率（目标2）的相关因素，父母为孩子接种疫苗的潜在障碍 HPV（目标3）和父母报告的HPV疫苗接种数据的有效性（目标4）。每项研究目标将针对 独特的研究问题，并将共同提供一个新的和全面的了解如何HPV 疫苗接种结果在西班牙裔亚组之间存在差异。我们预计，西班牙裔亚组的差异将 在每个研究目标中确定。由此产生的亚组特定数据将极大地影响 发展（即，当前HPV疫苗覆盖率、相关因素和障碍）和评估（即，有效性 父母报告的数据）的HPV疫苗干预和西班牙裔的监测工作。