Manipulating antibody production to maximise memory in vaccine responses

操纵抗体的产生以最大化疫苗反应中的记忆

• 批准号: nhmrc : 2002393
• 金额: $ 108.44万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/manipulating-antibody-production-vaccine-responses/1779897
• 关键词: Manipulating; antibody; production; maximise; memory

Our immune system provides protection from germs. The secretion of germ-specific proteins (antibodies) is an integral component of this defence and the basis of virtually all vaccines. Pandemics of Influenza and SARS-CoV-2 and failure to develop vaccines against HIV and Malaria remind us that our strategies need urgent improvement. Increasing our understanding of how our body defends us by specifically targeting foreign structures will reveal avenues for successful, rational vaccine development.

我们的免疫系统提供保护免受细菌。细菌特异性蛋白（抗体）的分泌是这种防御的组成部分，也是几乎所有疫苗的基础。流感和SARS-CoV-2的大流行以及未能研制出艾滋病毒和疟疾疫苗提醒我们，我们的战略迫切需要改进。增加我们对我们的身体如何通过专门针对外来结构来保护我们的理解，将揭示成功，合理的疫苗开发途径。