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Comparative Effectiveness Research and Patient Reported Outcomes in Diverticulitis

憩室炎的比较有效性研究和患者报告的结果

基本信息

批准号：
9492714
负责人：
anne peery
金额：
$ 19.36万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9492714
关键词：
Abdomen Abdominal Pain Acute Address Admission activity Adverse effects Affect Americas Amoxicillin Anorexia Antibiotic Therapy Antibiotics Award Chronic Clavulanate Clinical Clinical Sciences Cognitive Cohort Studies Communicable Diseases Constipation Data Data Set Development Diarrhea Digestive System Disorders Disease Diverticulitis Diverticulum Drug Approval Effectiveness Ensure Environment Epidemiology Escherichia coli Faculty Fever Fluoroquinolones Funding Future Gastroenterologist Gastrointestinal Diseases Goals Guidelines Health Care Costs Health Expenditures Hospitals Inflammation Institution Intervention Intervention Studies Interview Intestines Knowledge Medical Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Meta-Analysis Methods Metronidazole North Carolina Operative Surgical Procedures Outcome Outcome Measure Outcomes Research Outpatients Pain Patient Outcomes Assessments Patients Peer Review Pharmacoepidemiology Physicians Population Prevention trial Principal Investigator Privatization Productivity Public Health Publications Qualitative Research Quality of life Recommendation Recurrence Regimen Research Research Methodology Research Personnel Research Project Grants Research Training Resistance Risk Scientist Series Societies Solid Symptoms Tissues Training Translational Research United States National Institutes of Health Universities Visit Writing associated symptom career career development common treatment comparative effectiveness design disorder later incidence prevention effectiveness research evidence base experience gastrointestinal gastrointestinal symptom health care service utilization higher education instrument member novel patient oriented research relative effectiveness skills standard of care symposium treatment trial

项目摘要

PROJECT SUMMARY This is an application for a three-year mentored patient-oriented research career development award (K23). The overall goals are to 1) contribute to our understanding about the effectiveness, benefits and harms of antibiotics for acute diverticulitis and to develop a novel acute diverticulitis specific patient reported outcome measure through patient-oriented research; 2) educate and mentor the candidate clinician investigator while she transitions to independence. The candidate is a motivated clinical researcher at the University of North Carolina Chapel Hill with a background in digestive disease epidemiology and a solid publication record. The mentoring team includes an expert in gastrointestinal epidemiology (Sandler), pharmacoepidemiology and comparative effectiveness research (Sturmer) and patient reported outcome measures (Basch). Each member of the mentoring team has an established record of mentoring junior faculty, high research productivity, and substantial peer-reviewed support. The research and training environment at the University of North Carolina Chapel Hill is strong and well established. For fiscal year 2015, the University of North Carolina at Chapel Hill ranked ninth among both private and public universities nationwide for National Institutes of Health (NIH) research funding to domestic institutions of higher education. The candidate’s career development objectives are as follows: 1) to develop the knowledge and experience needed to perform analytic studies using large datasets with an emphasis on pharmacoepidemiology and comparative effectiveness research; 2) to develop knowledge and experience in patient-reported outcomes measures; 3) to transition to independence. To achieve these goals, the candidate will: 1) participate in advanced, graduate level coursework and conferences in pharmacoepidemiology, comparative effectiveness research and patient reported outcome measures; 2) attend The North Carolina Translational & Clinical Sciences Principal Investigator Development Series and join the R-Writing Group; 3) conduct mentor guided research. The specific aims of the research project are: 1) To evaluate the comparative effectiveness of antibiotic therapy with a combination a fluoroquinolone and metronidazole compared to amoxicillin-clavulanate alone for a first occurrence of medically managed outpatient acute diverticulitis on recurrence and complications using administrative claims data; 2) To develop an acute diverticulitis specific patient reported outcome measure: a) To identify the symptom domains relevant to patients with acute diverticulitis using qualitative research methods; b) To select items for an acute diverticulitis specific patient reported outcome measure using existing PRO instruments; c) To perform cognitive interviews with patients with acute diverticulitis to ensure content validity. The support and mentorship provided by a K23 is critical to achieve the candidate’s goal of transitioning to an independent physician-scientist in the field of digestive diseases.

项目总结