B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure (BLUSHED-AHF)
B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure (BLUSHED-AHF)
批准号:
9473074
负责人:
Peter S Pang
金额:
$35.83万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-04-17 至 2020-02-29
关键词:
Accident and Emergency departmentAcuteAlgorithmsAmericanBlood PressureBreathingCaringChronicCongestiveDiagnosisDiureticsEffectivenessEmergency Department PhysicianEmergency Department patientEnrollmentEnvironmental air flowExtravascular Lung WaterFailureFutureGoalsGuidelinesHeart failureHematocrit procedureHemoglobinHeterogeneityHospitalizationHospitalsHourIntravenousLearningLegLungMeasurementMeasuresMedication ManagementMorbidity - disease rateNitratesOutcomePatient CarePatientsPharmaceutical PreparationsPilot ProjectsPrognostic MarkerProtocols documentationRandomizedRecording of previous eventsReproducibilityResearch DesignResidual stateResolutionSafetySiteSwellingTechniquesTestingTimeTreatment FailureUltrasonographyVariantWaterWeight Gainbasediagnostic accuracyevidence baseimprovedimproved outcomemortalitynovel strategiesnovel therapeuticspatient populationpilot trialrecruittargeted treatmenttreatment as usual
中文摘要
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英文摘要
Title: B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure (BLUSHED-AHF)
ABSTRACT
Nearly 80% of acute heart failure (AHF) patients admitted to the hospital are initially treated in the emergency
department (ED). Once admitted, within 30 days post-discharge, 27% of patients are re-hospitalized or die.
Attempts to improve outcomes with novel therapies have all failed. The evidence for existing AHF therapies
are poor: No currently used AHF treatment is known to improve outcomes. ED treatment is largely the same
today as 40 years ago. Congestion, such as difficulty breathing, weight gain, and leg swelling, is the primary
reason why patients present to the hospital for AHF. Treating congestion is the cornerstone of AHF
management. Yet half of all AHF patients leave the hospital inadequately decongested. We propose a novel
approach to aggressively decongest patients in the ED setting: lung ultrasound guided, protocol driven, AHF
management. LUS B-lines are a measure of extra-vascular lung water (EVLW). In the setting of AHF, LUS are
a measure of congestion. This simple, easily learned technique has excellent reliability and reproducibility. We
hypothesize that a strategy-of-care will outperform usual care. At the present time, usual care is largely
empirical. This study will improve the evidence base for ED AHF management. This proposed pilot study, if
successful, will lead to an outcome trial examining whether an ED AHF strategy-of-care increases days alive
and out of the hospital for patients.
期刊论文(8)
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DOI:
10.1007/s11897-019-0424-1
发表时间:
2019-04-01
期刊:
Current heart failure reports
影响因子:
--
作者:
[Gupta, Richa, Testani, Jeffrey, Collins, Sean]
通讯作者:
Collins, Sean
DOI:
10.1097/cce.0000000000000015
发表时间:
2019-05-01
期刊:
Critical care explorations
影响因子:
--
作者:
[Ehrman, Robert R, Gallien, John Z, Sherwin, Robert L]
通讯作者:
Sherwin, Robert L
DOI:
10.1002/ehf2.12907
发表时间:
2020-10
期刊:
ESC heart failure
影响因子:
3.8
作者:
[Russell FM, Ferre R, Ehrman RR, Noble V, Gargani L, Collins SP, Levy PD, Fabre KL, Eckert GJ, Pang PS]
通讯作者:
Pang PS
DOI:
10.1016/j.jchf.2021.05.008
发表时间:
2021-09
期刊:
JACC. Heart failure
影响因子:
--
作者:
[Pang PS, Russell FM, Ehrman R, Ferre R, Gargani L, Levy PD, Noble V, Lane KA, Li X, Collins SP]
通讯作者:
Collins SP
B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure (BLUSHED-AHF)
-
批准号:9299462
-
项目类别:
-
资助金额:$40.02万
-
财政年份:2017
-
负责人:Peter S Pang
-
依托单位:
Using Short Stay Units (SSU) Instead of Routine Admission to Improve Patient Centered Health Outcomes for Acute Heart Failure (AHF) Patients.
-
批准号:9366626
-
项目类别:
-
资助金额:$39.99万
-
财政年份:2017
-
负责人:Peter S Pang
-
依托单位:
海外基金