BLR&D Research Career Scientist Award Application

目的：此应用程序的目标是竞争性地更新王建英博士的高级研究 荣获职业科学家(SRCS)奖，并继续支持王博士的退伍军人研究计划。 提名：王博士自2011年起担任高级研究职业科学家一职，他还 马里兰大学医学院外科和病理学系教授头衔 巴尔的摩大学医学院(UMSOM)。王博士的研究项目一直得到退伍军人管理局的资助- 功绩审查奖和多项NIH-R01奖助金超过22年。王医生已经有了 在他的职业生涯中取得了许多开创性的研究成果，并发表了140多篇同行- 回顾了已被引用超过5,000次的原始研究文章。此外，王博士还是一名 退伍军人事务部职业发展奖的主要导师/赞助商，他还在几个项目中担任联合调查员 目前正在进行由退伍军人管理局赞助的研究项目。 研究：王博士实验室的研究是为了研究肠道粘膜的机制 急性损伤后的再生和快速的上皮重建；以及进一步寻找新的和更多的 在危重病患者中维持肠道上皮完整性的有效治疗方法。有缺陷的 早期肠粘膜修复和随后的肠上皮完整性破坏的调节 常见于各种病理状态，如：应激性/消化性溃疡、克罗恩病 疾病/溃疡性结肠炎、大手术后、创伤和败血症。因为确切的机制 急性损伤后潜在的肠粘膜持续再生和快速粘膜修复仍然存在 含糊不清；保护肠道上皮完整性的有效治疗方法有限，特别是在患有 严重的外科疾病。王博士的研究项目高度关注快速肠道的调节 核糖核酸结合蛋白和非编码蛋白对粘膜修复和动态平衡的影响 健康和外科疾病中的RNA(NcRNAs)。他的研究项目研究与压力有关的过程 在限制性商业惯例和ncRNAs的调控下，影响靶基因表达的翻译后事件 细胞多胺的存在或不存在，以及限制性商业惯例和核糖核酸之间的相互作用 生理和病理条件。王博士的研究采用了最先进的技术， 包括检测特定信使(M)RNA/ncRNA或mRNA/RBP相互作用的方法 因为方法侧重于大规模的RNA分析。他的组织还广泛使用收益- 功能转基因和组织特异性基因敲除方法产生各种转基因 动物模型。重要的是，王博士的研究项目与患有 粘膜损伤/愈合延迟、适应不良、屏障功能障碍、炎症和败血症。这个 王博士研究计划的首要目标是阐明转录后过程 管理肠道粘膜再生和快速上皮修复，并为 肠粘膜损伤相关疾病的新疗法的发展。 影响：王博士的研究项目直接解决了与退伍军人管理局相关的一个重要的健康问题 使命，因为肠粘膜损伤相关疾病，如应激/消化性溃疡，克罗恩 疾病/溃疡性结肠炎和肠道屏障功能障碍在我们的VA患者群体中很常见。Dr。 王还积极与退伍军人事务部马里兰州医疗保健系统的一些调查人员合作 (VAMHCS)研究服务，以及他的专业知识和学术活动帮助推动VAMHCS研究 程序前进。

AIMS: The goal of this application is to competitively renew Dr. Jian-Ying Wang's Senior Research Career Scientist (SRCS) Award, and to continuously support Dr. Wang's VA research program. NOMINEE: Dr. Wang has held a position of Senior Research Career Scientist from 2011, and he also holds the title of Professor in the Departments of Surgery and Pathology at University of Maryland School of Medicine (UMSOM) at Baltimore. Dr. Wang's research program has been continuously funded by VA- MERIT Review Awards and multiple NIH-R01 grants for more than twenty-two years. Dr. Wang has had many seminal research accomplishments throughout his career, and published more than 140 peer- reviewed original research articles that have created more than 5,000 citations. In addition, Dr. Wang is a major mentor/sponsor for VA Career Development Awards, and he also acts as a co-investigator in several currently active VA-sponsored research projects. RESEARCH: Studies in Dr. Wang's laboratory are to investigate the mechanisms underlying gut mucosal regeneration and rapid epithelial restitution after acute injury; and to further search for new and more effective therapies to maintain the intestinal epithelial integrity in patients with critical illness. Defective regulation of early intestinal mucosal restitution and subsequent disruption of the gut epithelial integrity occur commonly in various pathological states such as: stress/peptic ulcerations, Crohn's disease/ulcerative colitis, post-massive surgery, trauma, and sepsis. Since the exact mechanisms underlying gut mucosal continuous regeneration and rapid mucosal repairs after acute injury are still obscure; effective therapies to preserve the gut epithelial integrity are limited, especially in patients with critical surgical illnesses. Dr. Wang's research program is highly focused on the regulation of rapid gut mucosal repair and homeostasis by Ribonucleic acid ( RNA)-binding proteins (RBPs) and noncoding RNAs (ncRNAs) in health and surgical diseases. His research program studies stress-related processes regulated by RBPs and ncRNAs, the post-translational events that affect target gene expression in the presence or absence of cellular polyamines, and the interplay between RBPs and ncRNAs under physiological and pathological conditions. Dr. Wang's research employs the state-of-the-art techniques, including approaches that examine specific messenger (m)RNA/ncRNA or mRNA/RBP interactions as well as approaches focused on large-scale RNA analyses. His group has also extensively used gain-of- function transgenic and tissue-specific knockout approaches to generate various genetically modified animal models. Importantly, Dr. Wang's research projects are directly relevant to surgical patients with mucosal injury/delayed healing, maladaptation, barrier dysfunction, inflammation, and sepsis. The overarching goal of Dr. Wang's research program is to elucidate the post-transcriptional processes that govern gut mucosal regeneration and rapid epithelial restitution, and to create a fundamental base for development of new therapeutics for gut mucosal injury-related diseases. IMPACT: Dr. Wang's research program directly addresses an important health issue relevant to the VA mission, since gut mucosal injury-related diseases such as stress/peptic ulcerations, Crohn's disease/ulcerative colitis, and gut barrier dysfunction occur commonly in our VA patient population. Dr. Wang also actively collaborates with a number of investigators in the VA Maryland Health Care System (VAMHCS) Research Service, and his expertise and academic activity help moving the VAMHCS research program forward.