A novel estrogen modulator for the treatment of Alzheimer's disease
一种用于治疗阿尔茨海默病的新型雌激素调节剂
基本信息
- 批准号:9898288
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-04-01 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsAffectAgeAge-associated memory impairmentAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer&aposs disease related dementiaAmyloid beta-ProteinAmyloidosisAnimalsAnti-Inflammatory AgentsAntioxidantsAttenuatedBiochemicalBiochemical MarkersBiological AssayBiological ModelsBlood Coagulation FactorBlood coagulationBrainCell Culture TechniquesCellsClinicalClinical TrialsCoagulation ProcessDataEnzyme-Linked Immunosorbent AssayEstrogensEvaluationEventFeminizationFutureGenetic EngineeringGenetically Engineered MouseGoalsGonadal Steroid HormonesHealthcare SystemsHippocampus (Brain)HistologicHormonesHumanImmunohistochemistryInbred C57BL MiceInvestigationLaboratoriesLesionMalignant NeoplasmsMeasurementMediatingMemoryMethodsMitochondriaMolecularMorbidity - disease rateMorphologyMusMutationNeuronsOncogenicOvariectomyPathway interactionsPatientsPharmaceutical PreparationsPharmacologyPostmenopausePreventionPrevention therapyPropertyProtocols documentationRNA InterferenceReverse Transcriptase Polymerase Chain ReactionRiskRoleSafetySeriesSignal PathwaySignal TransductionSynapsesTestingTg2576Transgenic MiceTransgenic OrganismsValidationVertebral columnWild Type MouseWomanaging brainbasebehavior testclinical developmentcostdensityestrogenicexperimental studyhuman subjectin vivoinhibitor/antagonistinterestmalemenmetal chelatormorris water mazemouse modelneuroprotectionneurotoxicneurotoxicitynormal agingnovelnovel therapeuticspreventprotective effectprotein aggregationreproductive organresponseside effectspatial memory
项目摘要
A number of studies have shown that the sex hormone, estrogen, has favorable or
“neurotrophic” effects on neuronal cells in the brain. Unfortunately, clinical trials using estrogen
revealed unacceptable side effects, including increased risk of blood clots and hormone-
sensitive cancers. Moreover, estrogen is not practical for use in men, because it promotes
unwanted physical changes and feminizing effects; consequently, estrogen has been
abandoned as a treatment for AD.
As an alterative strategy, the current study will test a novel drug called “STX”, which has the
favorable neurotrophic effects of estrogen without its unwanted side effects. Preliminary studies
indicate that STX protects neuronal cells against Alzheimer’s-associated toxic responses and
can be safely given to mice as they age. The overall goal is to determine if STX has potential
for treating Alzheimer’s disease in human patients.
This drug will be tested first on brain neuronal cells grown in a dish under conditions that mimic
specific aspects of Alzheimer’s disease, with the goal of identifying the molecular pathways that
control its protective responses. The drug will then will be tested in normal aging mice (to
confirm its safety), and in mice that have been genetically engineered to develop Alzheimer-type
changes in the brain. Established protocols will be used to carefully assess the effects of STX
on memory function, neuronal damage, and brain lesions associated with Alzheimer’ Disease.
These studies will integrate behavioral tests of spatial memory, immunohistochemical methods
to quantify neuronal damage, and biochemical assays to quantify protein aggregation.
Concurrently, the molecular pathways identified in cultured neuronal cells will be validated in the
brains of treated animals. Successful completion of these experiments will provide the
framework for advancing STX toward clinical trials.
许多研究表明,性激素,雌激素,有有利的或
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JOSEPH F QUINN其他文献
JOSEPH F QUINN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JOSEPH F QUINN', 18)}}的其他基金
ShEEP Request for Seahorse Analyzer for Measuring Mitochondrial Respiration
ShEEP 请求使用 Seahorse 分析仪来测量线粒体呼吸
- 批准号:
9908873 - 财政年份:2019
- 资助金额:
-- - 项目类别:
A novel estrogen modulator for the treatment of Alzheimer's disease
一种用于治疗阿尔茨海默病的新型雌激素调节剂
- 批准号:
10158406 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Biological signatures of the cognitive effects of Centella asiatica
积雪草认知影响的生物学特征
- 批准号:
9563219 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Targeting tau pathology with copper-modulating strategies in Alzheimers disease
通过铜调节策略针对阿尔茨海默病的 tau 病理学
- 批准号:
8634332 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Targeting tau pathology with copper-modulating strategies in Alzheimers disease
通过铜调节策略针对阿尔茨海默病的 tau 病理学
- 批准号:
9339519 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Targeting tau pathology with copper-modulating strategies in Alzheimers disease
通过铜调节策略针对阿尔茨海默病的 tau 病理学
- 批准号:
8974327 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Targeting tau pathology with copper-modulating strategies in Alzheimers disease
通过铜调节策略针对阿尔茨海默病的 tau 病理学
- 批准号:
8815001 - 财政年份:2014
- 资助金额:
-- - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
- 批准号:
2601817 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
- 批准号:
2029039 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
- 批准号:
9888417 - 财政年份:2019
- 资助金额:
-- - 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
- 批准号:
17K11318 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
-- - 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
- 批准号:
BB/M50306X/1 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
- 批准号:
288272 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Miscellaneous Programs