Biomarker Core

项目总结：生物标志物核心 Biomarker核心是为了支持OADRC的总体目标：提供一个结构和论坛，以 培养和发展在脑老化和痴呆方面的新的创新研究，并促进 与其他阿尔茨海默病的合作研究、科学互动和数据共享传输 中心、国家阿尔茨海默病协调中心、阿尔茨海默病合作研究单位、 阿尔茨海默病治疗联盟，国家阿尔茨海默病中央资料库 和相关的痴呆症，以及许多其他相关的外部研究小组。 OADRC的生物标记核心的使命是改进和最大限度地提高和最大限度地提高 用于研究的生物标记物样本和信息。它的组织是为了支持当前的研究，并预测 新知识和新技术使未来的研究需求成为可能。的具体目标 Biomarker核心如下： 1)获取生物标记物样本(DNA、血浆和脑脊液)并将其用于研究 OADRC受试者，包括健康对照组受试者，轻度认知障碍(MCI)受试者，以及 患有阿尔茨海默病和其他痴呆的受试者。 2)获取并提供OADRC受试者的生物标志物数据，以供研究使用。这将包括：a) 所有受试者的载脂蛋白E(ApoE)基因型，b)单核苷酸多态(SNP)图谱 选择队列，c)选择队列上的遗传风险分数，以及d)脑脊液Abeta、tau和ptau值 捐赠脑脊液用于研究的OADRC受试者。 3)促进涉及生物标记物和神经退行性疾病的合作研究。以下方面： OADRC的重点在概述中被描述为：(A)临床前痴呆和活动 强调年龄最大的老年人的疾病；(B)通过对 外周生物标记物、神经成像和持续的家庭行为监测；(C) 脑老化和老年痴呆的神经病理学；(D)新治疗方法的新测试；和(E) 改善教育，分享有关痴呆症的知识。这些领域将是核心的优先事项 支持协作工作。此外，OADRC认识到有责任支持所有NIH- 尽可能资助和可比较的同行评议研究。

Project Summary: Biomarker Core The Biomarker Core is aligned to support the overall goals of the OADRC: To provide a structure and forum to foster and develop new and innovative research in brain aging and the dementias, and to facilitate collaborative research, scientific interactions, and data sharing transfer with other Alzheimer’s Disease Centers, the National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Cooperative Study Unit, the Alzheimer’s Consortium Treatment Consortium, the National Centralized Repository for Alzheimer’s Disease and Related Dementias, and many other relevant outside research groups. The mission of the OADRC’s Biomarker Core is to improve and maximize the quality and availability of biomarker samples and information for research. It is organized to support current research, and to anticipate future research requirements made possible by new knowledge and new technologies. The Specific Aims of the Biomarker Core are as follows: 1) To obtain and make available for research, biomarker specimens (DNA, plasma, and CSF) from OADRC subjects, including healthy control subjects, subjects with mild cognitive impairment (MCI), and subjects with AD and other dementias. 2) To obtain and make available for research, biomarker data on OADRC subjects. This will include: a) apolipoprotein E (ApoE) genotype on all subjects, b) single nucleotide polymorphism (SNP) profiles on select cohorts, c) genetic risk scores on select cohorts, and d) CSF Abeta, tau, and ptau values for OADRC subjects who donate CSF for research. 3) To foster collaborative research involving biomarkers and neurodegenerative disease. The areas of emphasis for the OADRC have been described in the overview as (a) Preclinical dementia and activity of disease emphasizing the oldest old; (b) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; (c) Neuropathology of brain aging and late life dementia; (d) Novel testing of novel treatments; and (e) Improving education and sharing knowledge about dementia. These areas will be priorities for the Core to support in collaborative work. In addition, the OADRC recognizes a responsibility to support all NIH- funded and comparably peer-reviewed research whenever possible.