Biostatistics Core (RC3)

摘要 生物统计核心(RC3)是克劳德·D·佩珀老年美国人的四个资源核心之一 佛罗里达大学独立中心(OAIC)。UF OAIC的使命有两个：1) 通过跨学科的方法提高晚年的健康和独立性，以优化身体 业绩和行动能力；2)培训老龄和残疾研究方面的新调查人员； 培养他们的领导素质。RC3是来自不同物种的科学家之间相互作用的关键齿轮 完成这项任务所需的纪律。它提供研究设计和统计分析资源，并帮助 构建数据收集表格并管理数据(包括提供质量控制) 以及在OAIC内进行的临床研究。 RC3参与了OAIC研究的所有阶段：初步建议前研究设计和样本量 一旦收集到数据，就可以进行计算、随机化和最先进的统计分析。它也有帮助 准备在研究界内传播的手稿。此外，RC3还充当密钥 为OAIC初级教员和初级学者提供资源，提供咨询服务和定期特殊兴趣 培训主题，如研究设计、电力分析、数据管理、研究实施和 管理、统计方法和分析。最后，对于OAIC的研究，现有的 生物统计学方法是不够的，RC3已经聚集了强大的专业知识来开发新的 超越当前做法的生物统计方法和数据管理工具。RC3将开发新的 临床试验的适应性设计和同时统计推断的方法学。这将提供 满足OAIC研究设计和统计分析需求的定制支持。

SUMMARY The Biostatistics Core (RC3) is one of the four resource cores in the Claude D. Pepper Older Americans Independence Center (OAIC) at the University of Florida (UF). The mission of the UF OAIC is twofold: 1) to enhance late-life health and independence through interdisciplinary approaches to optimize physical performance and mobility, and 2) to train new investigators in research on aging and disability, while developing their leadership qualities. The RC3 is a key cog in the interaction among scientists from diverse disciplines to accomplish this mission. It provides research-design and statistical-analysis resources and helps construct data-collection forms and manage the data (including providing quality control) for both preclinical and clinical studies conducted within the OAIC. The RC3 is involved in all phases of the OAIC studies: initial pre-proposal study design and sample-size calculations, randomization, and state-of-the-art statistical analyses once the data are collected. It also helps prepare manuscripts for dissemination within the research community. In addition, the RC3 serves as a key resource to OAIC junior faculty and Junior Scholars, providing consulting services and periodic special-interest training topics, such as research design, power analysis, data management, study implementation and management, and statistical methodology and analyses. Finally, for OAIC studies where the existing biostatistical methodologies are inadequate, the RC3 has assembled strong expertise for developing new biostatistical methods and data-management tools beyond current practice. The RC3 will develop new methodology for adaptive design of clinical trials and simultaneous statistical inference. This will provide customized support that meets the demands of the OAIC's research design and statistical analyses.