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Delay Exposure Training and Allomorphic Choice

延迟暴露训练和异形选择

基本信息

批准号：
9414747
负责人：
Gregory J Madden
金额：
$ 7.25万
依托单位：
UTAH STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9414747
关键词：
Abstinence Alcohol or Other Drugs use Behavior Therapy Cocaine Diagnosis Drug usage Etiology Event Exhibits Female Food Funding Future Goals Health Human Human Characteristics Impulsivity Individual Intervention Investments Laboratories Learning Meta-Analysis Methods Mission Modeling Monkeys National Institute of Drug Abuse Nature Obesity Outcome Oxycodone Pathological Gambling Pharmaceutical Preparations Play Positioning Attribute Procedures Process Public Health Rattus Research Rewards Role Self Administration Self-Administered Self-control as a personality trait Solid Substance Addiction Substance Use Disorder Testing Therapeutic Time Training Translational Research Treatment Efficacy addiction behavioral health design discount discounting drug of abuse drug reward environmental intervention evidence base experience experimental study falls follow-up improved male non-drug physical conditioning preference prevent programs reduced substance use resilience social success therapy design

项目摘要

PROJECT SUMMARY/ABSTRACT A large body of research indicates that steeply discounting the value of delayed outcomes is robustly correlated with addictive disorders, but at present we do not know if discounting plays a causal role in drug taking. If steeply devaluing the future is causal, then investing in therapies designed to decrease delay discounting could prevent the initiation, or aid in the treatment of substance-use disorders. If no causal relation exists, investments in other therapeutic approaches would be indicated. To evaluate this causation hypothesis requires, first, a nonhuman procedure to capture the intertemporal and inter-commodity dynamics of the human drug-choice milieu; specifically, choosing between immediate drug use and delayed non-drug rewards. This allomorphic choice procedure has been successfully employed in only one study, only with oxycodone, and only with male rats. Specific Aim 1 will expand this procedure to cocaine self-administration and to male and female rats. Evaluating causation requires, second, a method of producing large and long-lasting reductions in impulsive choice. Building on past successes in male rats, Specific Aim 2 will evaluate the efficacy of this therapeutic method in female rats. Accomplishing these aims would pave the way for a follow-up R01-funded project designed to experimentally reduce delay discounting in males and female rats and then evaluating the effects of this reduction on allomorphic choice between immediate cocaine and delayed non-drug rewards. If rats trained to better tolerate delayed rewards self-administer less cocaine than control rats when non-drug rewards are increasingly delayed, then this would provide strong evidence for delay discounting as causal in the choice to consume a drug of abuse. Answering this question is important to the long-term mission of the National Institute on Drug Abuse as it will inform future translational research efforts to reduce substance use and dependence.

项目总结/文摘