ShEEP Request for ACQUITY UPLC H-Class PLUS Bio System

ShEEP 请求 ACQUITY UPLC H-Class PLUS 生物系统

• 批准号: 9905799
• 负责人: SUSHIL K MAHATA
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9905799
• 关键词: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Affect; Anesthesiology; Animals; Antineoplastic Agents; Award; Behavioral Research; Cardiology; Caregivers; Catecholamines; Cells; Chemicals; Communities; Complex; Computer software; Data; Degenerative polyarthritis; Detection; Diabetes Mellitus; Disease; Dopamine; Drug Addiction; Electronics; Endocrinology; Epinephrine; Fluorescence; Funding; Glucose; Glucose-6-Phosphate; Healthcare; Healthcare Systems; Heating; Hypertension; Injury; Insulin Resistance; Investigation; Length; Libraries; Lighting; Malignant Neoplasms; Measures; Mental Health; Mission; Monitor; Mus; Nephrology; Neurology; Neurotransmitters; Noise; Norepinephrine; Nucleotides; Obesity; Operative Surgical Procedures; Optics; Patients; Plasma; Polysaccharides; Pre-Clinical Model; Rattus; Research; Research Personnel; Resolution; Sampling; Serotonin; Sheep; Solvents; Sugar Phosphates; System; Temperature; Time; Tissues; Urology; Veterans; addiction; clinical care; data management; design; detector; glucose 1 phosphate; innovation; instrument; light emission; method development; optical emission; pre-clinical; pre-clinical research; response; solute; sugar nucleotide; systems research

Project Summary The capability to measure catecholamines (norepinephrine and epinephrine), neurotransmitters (dopamine and serotonin), nucleotides [adenosine monophosphate (AMP), adenosine diphosphate (ADP), and adenosine triphosphate (ATP)], sugar nucleotides (UDP glucose), sugar phosphates [glucose 1 phosphate (G1P) and glucose 6 phosphate (G6P), glycans and glycan derivatives] in small tissue or plasma samples will significantly and positively impact a large number of VA-sponsored projects in basic, translational and preclinical biomedical/behavioral research relevant to Veteran’s healthcare currently conducted at the VA San Diego Healthcare System (VASDHS). Catecholamines, neurotransmitters, nucleotides, sugar phosphates, glycans and glycan derivatives are affected several disease states including hypertension, diabetes, obesity, cancer, osteoarthritis, addiction and traumatic disorders. We are a group of 11 currently funded investigators with VA Merit Awards who will directly benefit from acquisition of the ACQUITY UPLC H-Class PLUS Bio system with Photodiode Array (PDA) and Fluorescence detectors. Our projects encompass a wide range of fields and research, including nephrology/hypertension, endocrinology, neurology, anesthesiology, cardiology, urology, and surgery. The acquisition of the ACQUITY UPLC H-Class PLUS Bio system with Photodiode Array (PDA) and Fluorescence detectors will not only impact basic pre-clinical research at VASDHS, but also is expected to have a strong and positive effect through improvement of patient clinical care and supporting the VA healthcare mission.

项目摘要 测量儿茶酚胺（去甲肾上腺素和肾上腺素）、神经递质 （多巴胺和血清素），核苷酸[腺苷一磷酸（AMP），腺苷二磷酸 (ADP)和三磷酸腺苷（ATP）]，糖核苷酸（UDP葡萄糖），糖磷酸 [葡萄糖1磷酸（G1 P）和葡萄糖6磷酸（G6 P）、聚糖和聚糖衍生物] 组织或血浆样本将对大量VA申办的 与退伍军人相关的基础，转化和临床前生物医学/行为研究项目 目前在VA圣地亚哥医疗保健系统（VASDHS）进行的医疗保健。儿茶酚胺， 神经递质、核苷酸、糖磷酸盐、聚糖和聚糖衍生物受到几种 疾病状态，包括高血压、糖尿病、肥胖、癌症、骨关节炎、成瘾和 创伤性精神障碍我们是一个由11名目前获得VA优异奖资助的调查人员组成的小组， 将直接受益于收购ACQUITY UPLC H-Class PLUS Bio系统（带光电二极管） 阵列（PDA）和荧光检测器。我们的项目涵盖广泛的领域， 研究，包括肾脏病学/高血压，内分泌学，神经病学，麻醉学，心脏病学， 泌尿外科和外科。ACQUITY UPLC H-Class PLUS Bio系统的购置 光电二极管阵列（PDA）和荧光检测器不仅会影响基础的临床前研究 在VASDHS，而且预计将通过改善患者 临床护理和支持VA医疗保健使命。