Novel mechanisms controlling signaling by adenosine monophosphate-activated protein kinase, central regulator of energy homeostasis

通过单磷酸腺苷激活蛋白激酶控制信号传导的新机制，能量稳态的中央调节器

• 批准号: FT130100988
• 负责人: A/Prof Jonathan Oakhill
• 金额: $ 50.73万
• 依托单位: St Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100988
• 关键词: Novel; mechanisms; controlling; signaling; adenosine

Sedentary lifestyles and consumption of high energy foods have led to dramatic increases in the incidence of obesity-related metabolic diseases such as type 2 diabetes and cardiovascular disease, placing enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK), which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Building on recent breakthroughs made at St. Vincent's Institute, this project will produce innovative research into novel mechanisms that control AMPK. These discoveries will greatly increase our understanding of AMPK regulation by cellular processes, and aid the design of more effective AMPK drugs.

久坐不动的生活方式和高能量食物的消费导致与肥胖相关的代谢疾病（如2型糖尿病和心血管疾病）的发病率急剧增加，给澳大利亚经济带来了巨大的财政和医疗负担。治疗这些疾病的一个有吸引力的药物靶点是AMP激活的蛋白激酶（AMPK），它既是细胞燃料计量器，又是全身代谢的协调者。基于圣文森特研究所最近取得的突破，该项目将对控制AMPK的新机制进行创新研究。这些发现将大大增加我们对AMPK通过细胞过程调节的理解，并有助于设计更有效的AMPK药物。