Modular and Project Based Training to Enhance Rigor and Reproducibility in Research for Diverse Biomedical Careers

模块化和基于项目的培训，以提高多样化生物医学职业研究的严谨性和可重复性

• 批准号: 9900317
• 负责人: Deepak Vashishth
• 金额: $ 8.64万
• 依托单位: RENSSELAER POLYTECHNIC INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-11-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9900317
• 关键词: Reproducibility; Research; Training; base; career

Abstract Given the multiple career choices in the field of biotechnology, a need has emerged to broadly train the predoctoral students in rigorous experimental design and transparency to enhance reproducibility in biomedical research. To this end, we will develop eight modular units in the following areas: Rigor of prior research; Scientific rigor in experimental design; Authentication of reagents and antibodies; Use and authentication of cell lines; Animal models and inclusion of biological variables; Data integrity; Effective strategies to include scientific rigor in research; and Effective communication of the need and importance of rigor and reproducibility in research. Each module will be developed and taught in person and via an online version to the NIGMS T32 trainee and graduate students from the Departments of Biology, Biomedical Engineering, Chemical Engineering and Chemistry at Rensselaer Polytechnic Institute. Using online quizzes, survey and in-person interviews the two methods of delivery will be evaluated for efficacy, effectiveness and sustainability. Based on the outcomes, a sequence of modular units will be developed and hosted online for training of graduate students at Rensselaer Polytechnic Institute and elsewhere.

抽象的 鉴于生物技术领域的多种职业选择，出现了广泛的需求 对博士前学生进行严格的实验设计和透明度培训，以提高 生物医学研究的可重复性。为此，我们将开发八个模块化单元 以下领域： 先前研究的严谨性；实验设计科学严谨；认证 试剂和抗体；细胞系的使用和鉴定；动物模型和纳入 生物变量；数据完整性；将科学严谨性纳入研究的有效策略；和 有效传达研究中严谨性和可重复性的必要性和重要性。 每个模块都将亲自开发和教授，并通过 NIGMS 的在线版本进行教授 T32 生物系、生物医学工程系的实习生和研究生， 伦斯勒理工学院化学工程和化学。使用在线测验， 调查和面对面访谈将评估这两种交付方法的有效性， 有效性和可持续性。根据结果​​，将形成一系列模块化单元 在线开发和托管，用于培训伦斯勒理工学院的研究生 研究所和其他地方。