Modular and Project Based Training to Enhance Rigor and Reproducibility in Research for Diverse Biomedical Careers

摘要 鉴于生物技术领域的多种职业选择，出现了广泛的需求， 在严格的实验设计和透明度方面培养博士预科生，以提高 生物医学研究的可重复性。为此，我们将在 以下领域：先前研究的严谨性;实验设计的科学严谨性; 试剂和抗体;细胞系的使用和鉴定;动物模型和纳入 生物变量;数据完整性;在研究中纳入科学严谨性的有效策略;以及 有效沟通研究中严谨性和可重复性的必要性和重要性。 每个模块都将亲自开发和教授，并通过NIGMS的在线版本进行 T32实习生和研究生来自生物学，生物医学工程， 伦斯勒理工学院化学工程与化学专业。使用在线测验， 调查和面对面访谈将评估这两种交付方法的功效， 有效性和可持续性。根据这些结果，将制定一系列模块化单元， 为伦斯勒理工学院研究生培训而在线开发和托管 研究所和其他地方。

Abstract Given the multiple career choices in the field of biotechnology, a need has emerged to broadly train the predoctoral students in rigorous experimental design and transparency to enhance reproducibility in biomedical research. To this end, we will develop eight modular units in the following areas: Rigor of prior research; Scientific rigor in experimental design; Authentication of reagents and antibodies; Use and authentication of cell lines; Animal models and inclusion of biological variables; Data integrity; Effective strategies to include scientific rigor in research; and Effective communication of the need and importance of rigor and reproducibility in research. Each module will be developed and taught in person and via an online version to the NIGMS T32 trainee and graduate students from the Departments of Biology, Biomedical Engineering, Chemical Engineering and Chemistry at Rensselaer Polytechnic Institute. Using online quizzes, survey and in-person interviews the two methods of delivery will be evaluated for efficacy, effectiveness and sustainability. Based on the outcomes, a sequence of modular units will be developed and hosted online for training of graduate students at Rensselaer Polytechnic Institute and elsewhere.