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BIOMOLECULAR SCIENCE AND ENGINEERING TRAINING PROGRAM

生物分子科学与工程培训项目

基本信息

批准号：
10620347
负责人：
Deepak Vashishth
金额：
$ 42.44万
依托单位：
RENSSELAER POLYTECHNIC INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10620347
关键词：
Engineering Science Training Programs

项目摘要

Abstract The Biomolecular Science and Engineering Training Program at Rensselaer Polytechnic Institute (RPI) is dedicated to the education of a broad and diverse pool of predoctoral students at the interface of biology, chemistry and engineering, focusing on the quantitative linkages that define this interface and prepare trainees for careers in biotechnology. The Program’s overarching objective is to provide the trainees with a keen understanding of the interdisciplinary nature of research, how it depends on fundamental underpinnings in both science and engineering, how it leads to innovative new scientific advances and technologies, and how basic science and engineering research can lead to new discoveries and commercial products that benefit society. The Training Program has been designed with key Program objectives to provide each trainee with a strong foundation in rigorous experimental design emphasizing rigor and reproducibility: to conduct ethical, responsible and productive predoctoral research with integrity and appropriate time-to-degree; to communicate and work effectively in teams with a diverse and broad pool of colleagues with multicultural sophistication; and to gain broad knowledge, professional skills and experiences for diverse careers in biomedical research. Our Training Program at RPI increases interactions among students from four departments: Biological Sciences, Biomedical Engineering, Chemical and Biological Engineering, and Chemistry and Chemical Biology, through courses, structured activities, research mentoring and training, and industrial experiences. Key activities of the Training Program include the following 12 Action Items: [A1] a core course entitled “Perspectives in Biomolecular Science and Engineering” that is taken by all trainees; [A2] a set of four courses that maximize didactic training among the key disciplines; [A3] a daylong technology commercialization boot camp to learn about fundamentals of intellectual property and participate in an entrepreneurial program; [A4] a high-profile seminar series that provides exposure to contemporary research in academia and industry; [A5] a student-run seminar program, in which trainees present their research to their peers and Program faculty; [A6] exposure to enrichment activities about human health, physiology, and disease, thereby promoting a healthcare innovation and entrepreneurial ecosystem; [A7] an annual retreat to network externally and hold discussions on contemporary research areas and careers in biotechnology; [A8] dual advising and multidisciplinary thesis committee membership for Ph.D. thesis work; [A9] an industrial internship; [A10] international Experience; [A11] training in responsible conduct of research, scientific rigor and reproducibility; and [A12] participation in a set of activities personalized for induvial development. Program committees and a trained evaluator conduct evaluations of the training process and outcomes to ensures that the trainees satisfy these requirements and that the overall Program goal and objectives are met through continuous process improvement.

摘要伦斯勒理工学院(RPI)的生物分子科学和工程培训计划致力于培养广泛而多样的生物学领域的博士前学生，化学和工程学，重点是定义这种界面和准备受训者的量化联系在生物技术方面的职业生涯。该计划的首要目标是为学员提供一个敏锐的理解研究的跨学科性质，以及它如何依赖于两者的基本基础科学和工程，它如何导致创新的新的科学进步和技术，以及如何基础科学和工程研究可以带来有益于社会的新发现和商业产品。培训计划的设计具有关键的计划目标，为每个受训者提供强大的以严谨的实验设计为基础，强调严谨和重复性：进行合乎道德的、负责任和富有成效的博士前研究，正直和适当的时间到学位；沟通并与具有多种文化背景的不同和广泛的同事组成的团队有效地工作；以及在生物医学研究的不同职业中获得广泛的知识、专业技能和经验。我们在RPI的培训计划增加了来自四个系的学生之间的互动：生物学科学、生物医学工程、化学和生物工程、化学和化学生物，通过课程、有组织的活动、研究指导和培训以及工业经验。培训方案的主要活动包括以下12个行动项目：[A1]题为 “生物分子科学与工程展望”，所有学员都要选修；[A2]一套四门课程在关键学科中最大限度地进行教学培训；[A3]为期一天的技术商业化启动夏令营学习知识产权的基本知识并参加创业方案；[A4]a 高调系列研讨会，提供对学术界和工业界当代研究的接触；[A5]a 学生举办的研讨会计划，受训者向他们的同行和计划教职员工展示他们的研究；[A6] 接触有关人类健康、生理和疾病的丰富活动，从而促进医疗创新和创业生态系统；[A7]向外部网络和举办的年度务虚会关于当代生物技术研究领域和职业的讨论；[A8]双重建议和博士论文工作的多学科论文委员会成员；[A9]工业实习；[A10] 国际经验；[A11]负责任地进行研究、科学严谨和可再现性方面的培训；和[A12]参加一系列针对工业发展的个性化活动。计划委员会和一个训练有素的评估员对培训过程和结果进行评估，以确保受训者满意这些要求以及整个计划的目标和目的通过持续的过程得到满足进步。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Continuous precipitation-filtration process for initial capture of a monoclonal antibody product using a four-stage countercurrent hollow fiber membrane washing step.

使用四阶段逆流中空纤维膜洗涤步骤初始捕获单克隆抗体产品的连续沉淀过滤过程。

DOI：
10.1002/bit.28525
发表时间：
2023
期刊：
Biotechnology and bioengineering
影响因子：
3.8
作者：
Minervini,Mirko;Mergy,Matthew;Zhu,Yuncan;GutierrezDiaz,MarioA;Pointer,Craig;Shinkazh,Oleg;Oppenheim,SheldonF;Cramer,StevenM;Przybycien,ToddM;Zydney,AndrewL
通讯作者：
Zydney,AndrewL

NgCAM and VAMP2 reveal that direct delivery and dendritic degradation maintain axonal polarity.