Immunology Core

免疫学核心

• 批准号: 9899927
• 负责人: SCOTT D GRAY-OWEN
• 金额: $ 27.89万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9899927
• 关键词: Antigen Targeting; Antigens; Bacteria; Bacterial Adhesins; Bacterial Attachment Site; Base Sequence; Binding Proteins; Bioinformatics; Blood; Cells; Complement; Complement Factor H; Core Protein; Data; Data Protection; Detection; Development; Disease; Engineering; Enzyme-Linked Immunosorbent Assay; Epidemiology; Epithelial; Epithelium; Female; Gonorrhea; Herd Immunity; Human; Immune; Immune response; Immunity; Immunization; Immunologics; Immunology; In Vitro; Individual; Infection; Iron; Iron-Binding Proteins; Lactoferrin; Leukocyte L1 Antigen Complex; Libraries; Measures; Mediating; Membrane Proteins; Modeling; Mucous Membrane; Mus; Neisseria gonorrhoeae; Nutrient; Pathway interactions; Pelvic Inflammatory Disease; Population; Proteins; S100A7; Site; Source; Structure; Testing; Tissues; Transferrin; Transgenic Mice; Trees; Urethra; Vaccine Design; Vaccines; Variant; Zinc; bactericide; base; complement 4b-binding protein; cross reactivity; design; epidemiological model; humanized mouse; immunogenicity; innovation; male; mathematical model; mouse model; pathogen; protective efficacy; reproductive tract; tool; transmission process; vaccine development; vaccine efficacy; vaccine evaluation

Summary This Core component will take advantage of our established vaccine evaluation pipeline, which includes our innovative high throughput approaches facilitate our antigen engineering efforts by simultaneously allowing the reactivity of antiserum to be measured against all known antigenic variants of a given protein, and our humanized mouse-based infection models, which allow us to test the protective efficacy of vaccines during gonococcal asymptomatic colonization and disease. The results generated by this Core are central to vaccine design and formulation efforts being undertaken in Projects 1 and 2, and will be used to inform the vaccine impact modeling being performed in Project 3.

总结 该核心组件将利用我们已建立的疫苗评估管道，其中包括我们的 创新性的高通量方法通过同时允许抗原分子在细胞中的表达来促进我们的抗原工程努力。 要测量的抗血清对给定蛋白质的所有已知抗原变体的反应性，以及我们的 人源化的小鼠感染模型，这使我们能够测试疫苗的保护效力， 淋球菌无症状定植和疾病。该核心产生的结果对疫苗至关重要。 在项目1和2中正在进行的设计和制定工作，并将用于告知疫苗 在项目3中进行的影响建模。