University of Minnesota Clinical and TranslationalmScience Institute (UMN CTSI)

联系PD/PI：Blazar，布鲁斯 A.总体：抽象。明尼苏达大学临床和转化科学研究所（UMN CTSI）的愿景是一个世界，其中有影响力的发现导致人类健康的改善， 将学术健康中心（AHC）研究与社区外展和行业结合起来 伙伴关系我们的使命是创建一个全国公认的，可共享的复杂翻译团队模式 通过整合和调整临床和转化科学（CTS）研究， 教育、数据访问、社区需求和行业努力。在过去的6年里，CTSI 1）开发了 全面的劳动力培训计划，促进下一代的职业发展 CTS研究调查员; 2）创建社区参与，以推进研究和社区 支持利益相关者社区对CTS研究的贡献，并解决健康问题 索马里人、拉丁美洲人、美洲原住民、苗族人和其他人群的结果差异挑战; 3） 利用UMN的研究优势和MN充满活力的生物医学产业，沿着推进多个项目 商业化途径;以及4）从UMN三级护理成人扩大其患者基础， 儿科医院到枢纽合作伙伴，包括VA医院，基于社区的7医院系统，以及 安全网县医院，65%的种族/少数民族与i2 b2/SHRINE相关，用于队列识别。 CTSI与马约CTSA建立了前所未有的合作伙伴关系，为CTS提供全州范围的覆盖 研究和教育，是中西部地区健康研究联盟的创始成员， 加入临床试验联合队列发现联盟和PCORnet大平原协作组织。 为了加速和改善CTS的研究和教育，并对医疗保健结果产生持久的影响， 我们会致力达致以下目标：在全球范围内培养一支优秀的多学科、多元化的员工队伍 CTS研究频谱熟练，并奖励团队科学使用现有的和新的教育 报价; 2.简化方法和流程，以提高地方和国家CTSI中心的研究能力 在一个新的诊所和外科中心学习健康系统与CTSI领导的研究过程设计，CTSI的 新的研究工具，用户友好的IRB批准的临床和实验室研究知情同意书，生物信息学， matics工具，生物标本采集，以及一个变革性的临床研究支持中心， 单一位置，所需审批的并行处理; 3.通过以下方式与社区和利益相关者互动 CEOMENTO在整个生命周期内改善翻译和医疗保健服务，并向不同人群提供服务;以及 4.儿科发现和翻译办公室为CTSA网络做出独特贡献 设备创新联盟，以及高和低磁共振成像和光谱学 应用和培训。冲击CTSI与其愿景和使命相联系，并受其驱动，将提供 基础设施和服务进行创新，高影响力和高效，高质量的CTS研究。 项目摘要/摘要第391页 联系PD/PI：Blazar，布鲁斯

Contact PD/PI: Blazar, Bruce A. Overall: Abstract. The University of Minnesota's Clinical and Translational Science Institute's (UMN CTSI) vision is a world where impactful discoveries leading to the betterment of human health occur by bringing together Academic Health Center (AHC) research with community outreach and industry partnership. Our mission is to create a nationally-recognized, shareable model of complex translational team science driven and enabled by integration and alignment of clinical and translational science (CTS) research with education, data access, community needs, and industry efforts. In the past 6 years, CTSI 1) Developed comprehensive programs for workforce training and fostering career development for the next generation of CTS research investigators; 2) Created Community Engagement to Advance Research and Community Health (CEARCH) to support stakeholder community contributions to CTS research and to tackle health outcome disparity challenges in Somali, Latino, Native American, Hmong, and other populations; 3) Leveraged UMN research strengths and MN's vibrant biomedical industry to advance multiple projects along the commercialization pathway; and 4) Expanded its patient base from the UMN tertiary care adult and pediatric hospitals to hub partners consisting of a VA hospital, a community-based 7-hospital system, and a safety-net county hospital with 65% racial/ethnic minorities linked with i2b2/SHRINE for cohort identification. CTSI formed an unprecedented partnership with Mayo CTSA to provide statewide coverage in CTS research and education and is a founding member of the Midwest Area Research Consortium for Health, the Accrual to Clinical Trials federated cohort discovery consortium, and PCORnet Greater Plains Collaborative. To accelerate and improve CTS research and education and make lasting impacts on healthcare outcomes, we will pursue the following aims: 1. Train an outstanding multidisciplinary, diverse workforce across the CTS research spectrum skilled in and rewarded for team science using existing and new educational offerings; 2. Streamline methods and processes to increase local and national CTSI hub research capacity in a new Clinics and Surgery Center learning health system with CTSI-led research process design, CTSI's new StudyFinder tool, user-friendly IRB-approved consent form for clinical and laboratory research, bioinfor- matics tools, biospecimen collection, and a transformative Clinical Research Support Center for one-stop, single location, parallel processing of needed approvals; 3. Engage communities and stakeholders through CEARCH to improve translation and healthcare delivery across the lifespan and to a diverse population; and 4. Add unique contributions to the CTSA network by the Office of Discovery and Translation , Pediatric Device Innovation Consortium, and high and ultrahigh magnetic resonance imaging and spectroscopy applications and training. Impact. Connected to and driven by its vision and mission, CTSI will provide infrastructure and services for conducting innovative, high-impact and efficient, high-quality CTS research. Project Summary/Abstract Page 391 Contact PD/PI: Blazar, Bruce