Breathing Research and Therapeutics (BREATHE)

呼吸研究和治疗（BREATHE）

• 批准号: 9901627
• 负责人: Gordon S. Mitchell
• 金额: $ 36.7万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901627
• 关键词: Breathing; Research; Therapeutic

ABSTRACT In this revised application, we propose a new pre- and post-doctoral training program at the University of Florida: Breathing REsearch And THErapeutics (BREATHE). Our proposal is to create a training program focused on the respiratory neuromuscular system, emphasizing the discovery of new knowledge and its translation to neuromuscular disorders that compromise breathing and airway defense. Diminished breathing capacity, unstable breathing and/or aspiration pneumonia from inadequate airway defense are hallmarks of many neuromuscular disorders, and respiratory failure is the most common cause of death. However, despite the fundamental importance of breathing and airway defense to the quality and duration of life in patients with degenerative neuromuscular diseases (eg. Muscular Dystrophy, Pompe Disease, ALS) or neural injury (eg. spinal cord injury), we know of no other training program with similar focus on breathing and airway defense in in these conditions. Our proposal directly addresses this critical gap in NHLBI funded research training. The ultimate goal of the BREATHE Training Program is to develop a unique cohort of researchers with strong foundations in basic research on respiratory neuromuscular biology, and a strong appreciation for the needs/realities of translational research in our attempts to develop treatments for impaired breathing and/or airway defense. Our perspective is that we can accelerate progress towards development of effective treatments for impaired breathing capacity/stability in diverse neuromuscular disorders by training investigators with: 1) a well-developed and comprehensive conceptual framework embracing similarities and differences between neuromuscular clinical disorders; and 2) a state-of-the-art “tool kit,” providing the technological know- how to perform meaningful investigations in animal models and humans with spontaneous disease. We will train individuals with diverse academic backgrounds, including neuroscience, muscle biology, engineering and/or clinical training (physicians, physical or speech therapists and veterinarians; including multiple specialties in each group). A hallmark of our program will be “cross-training,” where basic scientists are exposed to meaningful clinical experiences, and clinician scientists establish strong basic research foundations. We will capitalize on existing, and building strengths at the University of Florida to provide an integrated research-training program in respiratory neuromuscular biology and translational research. The UF Health Science Center has demonstrated its commitment to this area of research by creating a new Center for Respiratory Research and Rehabilitation. This Center, and other strengths at the UF Health Science Center, will provide an exceptional academic environment for the BREATHE Training Program.

摘要 在这份修订后的申请中，我们建议在加州大学设立一个新的博士后和博士后培训计划。 佛罗里达州：呼吸研究和治疗(呼吸)。我们的建议是创建一个培训计划 侧重于呼吸神经肌肉系统，强调新知识的发现及其 转化为影响呼吸和呼吸道防御的神经肌肉疾病。呼吸减弱 容量、呼吸不稳定和/或因呼吸道防御不足而导致的吸入性肺炎是 许多神经肌肉疾病，以及呼吸衰竭是最常见的死亡原因。然而，尽管 呼吸和呼吸道防御对慢性支气管炎患者生活质量和持续时间的根本重要性 退行性神经肌肉疾病(如肌营养不良症、庞贝病、肌萎缩侧索硬化症)或神经损伤。 脊髓损伤)，我们知道没有其他训练计划在呼吸和呼吸道防御方面有类似的重点 在这种情况下。我们的建议直接解决了NHLBI资助的研究培训中的这一关键缺口。这个 呼吸训练计划的最终目标是培养一支独特的研究人员队伍，具有强大的 呼吸系统神经肌肉生物学的基础研究，以及对 在我们尝试开发呼吸障碍和/或呼吸障碍的治疗方法时，翻译研究的需求/现实 呼吸道防御。我们的观点是，我们可以加快发展有效的 通过培训研究人员治疗各种神经肌肉疾病的呼吸能力/稳定性受损 具有：1)包括相同和不同的完善和全面的概念框架 在神经肌肉临床疾病之间；以及2)最先进的“工具包”，提供技术知识- 如何在动物模型和患有自发性疾病的人类中进行有意义的研究。我们会 培养具有不同学术背景的个人，包括神经科学、肌肉生物学、工程学 和/或临床培训(医生、物理或语言治疗师和兽医；包括多名 每一组的特长)。我们项目的一个标志是“交叉培训”，即基础科学家 接触到有意义的临床经验，临床科学家建立了强大的基础研究 基金会。我们将利用佛罗里达大学现有的和正在积累的优势来提供 呼吸系统神经肌肉生物学和翻译研究的综合研究-培训计划。UF 健康科学中心通过创建一个新的中心来展示其对这一研究领域的承诺 呼吸系统研究与康复。这个中心，以及UF健康科学中心的其他优势， 将为呼吸训练计划提供一个特殊的学术环境。