Breathing Research and Therapeutics (BREATHE)

呼吸研究和治疗（BREATHE）

• 批准号: 9901627
• 负责人: Gordon S. Mitchell
• 金额: $ 36.7万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901627
• 关键词: Breathing; Research; Therapeutic

ABSTRACT In this revised application, we propose a new pre- and post-doctoral training program at the University of Florida: Breathing REsearch And THErapeutics (BREATHE). Our proposal is to create a training program focused on the respiratory neuromuscular system, emphasizing the discovery of new knowledge and its translation to neuromuscular disorders that compromise breathing and airway defense. Diminished breathing capacity, unstable breathing and/or aspiration pneumonia from inadequate airway defense are hallmarks of many neuromuscular disorders, and respiratory failure is the most common cause of death. However, despite the fundamental importance of breathing and airway defense to the quality and duration of life in patients with degenerative neuromuscular diseases (eg. Muscular Dystrophy, Pompe Disease, ALS) or neural injury (eg. spinal cord injury), we know of no other training program with similar focus on breathing and airway defense in in these conditions. Our proposal directly addresses this critical gap in NHLBI funded research training. The ultimate goal of the BREATHE Training Program is to develop a unique cohort of researchers with strong foundations in basic research on respiratory neuromuscular biology, and a strong appreciation for the needs/realities of translational research in our attempts to develop treatments for impaired breathing and/or airway defense. Our perspective is that we can accelerate progress towards development of effective treatments for impaired breathing capacity/stability in diverse neuromuscular disorders by training investigators with: 1) a well-developed and comprehensive conceptual framework embracing similarities and differences between neuromuscular clinical disorders; and 2) a state-of-the-art “tool kit,” providing the technological know- how to perform meaningful investigations in animal models and humans with spontaneous disease. We will train individuals with diverse academic backgrounds, including neuroscience, muscle biology, engineering and/or clinical training (physicians, physical or speech therapists and veterinarians; including multiple specialties in each group). A hallmark of our program will be “cross-training,” where basic scientists are exposed to meaningful clinical experiences, and clinician scientists establish strong basic research foundations. We will capitalize on existing, and building strengths at the University of Florida to provide an integrated research-training program in respiratory neuromuscular biology and translational research. The UF Health Science Center has demonstrated its commitment to this area of research by creating a new Center for Respiratory Research and Rehabilitation. This Center, and other strengths at the UF Health Science Center, will provide an exceptional academic environment for the BREATHE Training Program.

抽象的 在这份修订后的申请中，我们提出了在英国大学开展新的博士前和博士后培训计划。 佛罗里达州：呼吸研究和治疗学 (BREATHE)。 Our proposal is to create a training program 专注于呼吸神经肌肉系统，强调新知识及其发现 转化为损害呼吸和气道防御的神经肌肉疾病。呼吸减弱 容量、呼吸不稳定和/或气道防御不足导致的吸入性肺炎是 许多神经肌肉疾病，而呼吸衰竭是最常见的死亡原因。然而，尽管 呼吸和气道防御对患者生命质量和寿命的根本重要性 degenerative neuromuscular diseases (eg. Muscular Dystrophy, Pompe Disease, ALS) or neural injury (eg. 脊髓损伤），据我们所知，没有任何其他训练计划能够与呼吸和气道防御类似地关注 在这些条件下。我们的提案直接解决了 NHLBI 资助的研究培训中的这一关键差距。这 BREATHE 培训计划的最终目标是培养一批具有强大能力的独特研究人员 foundations in basic research on respiratory neuromuscular biology, and a strong appreciation for the 在我们尝试开发呼吸障碍和/或受损治疗方法时，转化研究的需求/现实 气道防御。 Our perspective is that we can accelerate progress towards development of effective 通过培训研究人员对各种神经肌肉疾病的呼吸能力/稳定性受损进行治疗 with: 1) a well-developed and comprehensive conceptual framework embracing similarities and differences between neuromuscular clinical disorders; 2）最先进的“工具包”，提供技术知识 how to perform meaningful investigations in animal models and humans with spontaneous disease.我们将 train individuals with diverse academic backgrounds, including neuroscience, muscle biology, engineering and/or clinical training (physicians, physical or speech therapists and veterinarians; including multiple specialties in each group). A hallmark of our program will be “cross-training,” where basic scientists are exposed to meaningful clinical experiences, and clinician scientists establish strong basic research 基础。 We will capitalize on existing, and building strengths at the University of Florida to provide an integrated research-training program in respiratory neuromuscular biology and translational research.超滤 Health Science Center has demonstrated its commitment to this area of research by creating a new Center for Respiratory Research and Rehabilitation. This Center, and other strengths at the UF Health Science Center, will provide an exceptional academic environment for the BREATHE Training Program.