Core C - Stem Cell Core
核心 C - 干细胞核心
基本信息
- 批准号:9902284
- 负责人:
- 金额:$ 28.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AgeAgingBiological AssayBone MarrowC57BL/6 MouseCartilageCellsCollaborationsCore FacilityDataData SetDisciplineElementsEnsureFacultyFatty acid glycerol estersHumanHypoxiaImpairmentIndividualKnockout MiceLaboratoriesMarrowMesenchymalMesenchymal Stem CellsMetabolic Bone DiseasesMusMusculoskeletal DiseasesNutrientProceduresProductionQuality ControlReagentResearchResearch PersonnelResourcesSignal TransductionStem Cell ResearchTestingTimeTransgenic OrganismsTrustUniversitiesWorkbonebone losscell typecostdesigninterestmouse modelmultidisciplinaryosteogenicprogramssoundstemstem cellssuccess
项目摘要
The main function of the Bone Stem Cell Core (Core C) is to isolate and distribute bone marrow-
derived mesenchymal stem/progenitor cells (BMSCs) to the investigators of the individual
projects, and to provide technical support for use of the cells. A key component essential to the
success of the proposed Program Project is the availability of BMSCs because all projects
require these cells. Thus, a centralized Core facility for the production of quality cells is crucial
to the success of this dynamically coordinated Program Project. This Core will benefit the
research efforts of individual investigator by reducing costs, providing quality control for study
procedures, and enhancing collaborations among multiple disciplines to achieve greater
scientific gain through an integrated approach. In addition, production and distribution of cells
from a centralized facility will ensure that all studies start with cells of the same lineages and
background. The Specific Aims are: 1. Isolate, characterize and distribute mouse BMSCs,
human bone marrow MSCs (hMSCs), and 2. Provide ongoing technical support for hypoxic and
conventional MSC culture and differentiation (osteogenic, adipogenic, and chondrogenic)
assays. By achieving these objectives, this Core will function as a unique resource to provide
mouse and human BMSCs and technical assistance to the individual projects, as well as to
other Georgia Regents University investigators who are interested in studies related to aging,
metabolic bone diseases, or stem cell research.
骨干细胞核心(Core C)的主要功能是分离和分配骨髓-
来源的间充质干/祖细胞(BMSC)的研究人员的个人
项目,并为使用细胞提供技术支持。一个关键的组成部分,
拟议的计划项目的成功是BMSC的可用性,因为所有项目
需要这些细胞。因此,集中的核心设施生产优质电池至关重要
这一动态协调的计划项目的成功。这一核心将有利于
通过降低成本,为研究提供质量控制,
程序,并加强多学科之间的合作,以实现更大的
通过综合方法获得科学收益。此外,细胞的生产和分布
将确保所有研究从相同谱系的细胞开始,
背景具体目标是:1。分离、表征和分配小鼠BMSC,
人骨髓间充质干细胞(hMSC),和2.提供持续的技术支持,
常规MSC培养和分化(成骨、成脂和成软骨)
分析。通过实现这些目标,该核心将作为一种独特的资源,
小鼠和人类骨髓间充质干细胞和技术援助的个别项目,以及
其他对衰老相关研究感兴趣的格鲁吉亚摄政大学研究人员,
代谢性骨病或干细胞研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('XINGMING SHI', 18)}}的其他基金
Modulation of Age-Related Inflammation by PPAR
PPAR 调节年龄相关炎症
- 批准号:
10228840 - 财政年份:2020
- 资助金额:
$ 28.36万 - 项目类别:
Transcriptional Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zippe
糖皮质激素诱导的亮氨酸 Zippe 对 PPARgamma-2 的转录抑制
- 批准号:
8034954 - 财政年份:2010
- 资助金额:
$ 28.36万 - 项目类别:
PPARgamma-2 Transcriptional Repression by Glucocorticoid-induced Leucine Zipper
糖皮质激素诱导的亮氨酸拉链对 PPARgamma-2 转录抑制
- 批准号:
8079481 - 财政年份:2008
- 资助金额:
$ 28.36万 - 项目类别:
Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zipper
糖皮质激素诱导的亮氨酸拉链对 PPARgamma-2 的抑制
- 批准号:
8305708 - 财政年份:2008
- 资助金额:
$ 28.36万 - 项目类别:
Transcriptional Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zippe
糖皮质激素诱导的亮氨酸 Zippe 对 PPARgamma-2 的转录抑制
- 批准号:
7668473 - 财政年份:2008
- 资助金额:
$ 28.36万 - 项目类别:
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