Novel in-vivo ultrasound-based point-of-care instrument to assess myopia level and progression

用于评估近视程度和进展的新型体内超声护理仪器

• 批准号: 9903615
• 负责人: JONATHAN MAMOU
• 金额: $ 27.36万
• 依托单位: RIVERSIDE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2022-04-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9903615
• 关键词: Adoption; Animal Model; Anterior; Biometry; Blindness; Caring; Clinical; Clinical Research; Computer software; Computers; Data; Degenerative Myopia; Development; Device or Instrument Development; Devices; Disease; Disease Progression; Elements; Evaluation; Eye; Eye Banks; Feedback; Frequencies; Gel; Human; Knowledge; Length; Measurement; Measures; Mechanics; Methods; Myopia; Ophthalmologist; Ophthalmology; Output; Patients; Physiologic pulse; Play; Point-of-Care Systems; Prevalence; Process; Property; Refractive Errors; Regulation; Research; Research Institute; Role; Safety; Sclera; Severities; Severity of illness; Signal Transduction; Singapore; Structure; System; Testing; Time; Transducers; Ultrasonography; Validation; Vision; arm; base; clinical research site; cost; data acquisition; design; elastography; eye center; graphical user interface; in vivo; innovation; instrument; mechanical properties; novel; point of care; portability; prospective; prototype; quantitative ultrasound; radio frequency; soft tissue; statistics; time use; touchscreen

This proposed project is intended to develop a novel, low-cost, compact, point-of-care (POC) ultrasound system to assess myopia severity and progression in vivo. Myopia prevalence is increasing worldwide and pathologic myopia is one of the leading causes of blindness. Myopia originates from structural and mechanical changes in the sclera that precede vision-threatening ocular changes. Currently, no method exists to assess myopia progression and severity quantitatively in vivo, and this project seeks to fill this gap. The POC instrument to be developed will consist of a single-element, spherically focused transducer operating at an 80-MHz center frequency mounted in a handheld probe and connected to a computer equipped with dedicated software, hardware, and a touch screen for ease of use using a graphical user interface. The POC instrument will collect RF, A-line data at a high pulse-repetition frequency while in direct contact with the anterior sclera. The RF data will be processed using QUS methods to derive so- called QUS estimates associated with the elastic and microstructural properties of the sclera. The QUS estimates will be based on the backscatter coefficient and envelope statistics as well as on highly- innovative passive elastography. The POC instrument will be portable, low-cost, real-time, and nonionizing. It will be very similar to pachymeters currently used by ophthalmologists for biometric measurements, which will facilitate its adoption by clinicians. In Year 2, the POC instrument will be deployed at our collaborating clinical site, the Singapore Eye Research Institute, to acquire and process data from 100 patients during a prospective clinical study aimed at assessing the value of the POC instrument for evaluating high-myopia patients. Specifically, the clinical study will test the ability of the system to predict myopia severity and progression. If successful, these studies will not only advance myopia knowledge significantly, but, equally important, the proposed POC instrument will revolutionize care for myopia patients by providing a low-cost, easy-to-use, and safe means to assess disease severity and progression.

本项目旨在开发一种新颖、低成本、紧凑、即时护理（POC）的超声波