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Insular Cortex and Social Affect

岛叶皮质和社会影响

基本信息

批准号：
9902547
负责人：
John Paul Christianson
金额：
$ 39.13万
依托单位：
BOSTON COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9902547
关键词：
Address Adolescent Adult Affect Affective Age Amygdaloid structure Anatomy Animals Behavior Behavioral Behavioral Paradigm Brain Cells Cognition Cues Data Decision Making Detection Development Disease Distress Emotional Emotions Empathy Exposure to Fragile X Syndrome Functional Magnetic Resonance Imaging Functional disorder Gap Junctions Genetic Human Individual Insula of Reil Label Link Mediating Mental disorders Methods Modeling Neurons Nucleus Accumbens Pathologic Pathway interactions Positioning Attribute Primates Process Rattus Research Research Personnel Rewards Rodent Sensory Shapes Signal Transduction Social Behavior Social Interaction Stimulus Stress System Techniques Testing Theoretical model Work approach avoidance behavior approach behavior autism spectrum disorder base behavior test behavioral response blood oxygenation level dependent response emotional stimulus emotional symptom experience experimental study improved integration site loss of function member multidisciplinary multimodality neural circuit novel optogenetics pre-clinical preference prevent psychosocial response reward processing social social cognition social deficits social engagement social integration theories transmission process

项目摘要

Abstract Disorders involving social behaviors such as autism spectrum disorder are increasingly prevalent, yet the pathophysiological bases for these conditions elude researchers and current treatments are woefully inadequate. The insular cortex is highly implicated in both normal and pathological social affective processes such as emotion recognition and empathy. The insular cortex receives a major input from the amygdala and so it is likely a site of integration for social and emotional information leading to modulation of social approach and avoidance behaviors via insular projections to the nucleus accumbens. Using a simple rodent social behavioral test in which rats display approach behaviors to conspecifics in distress, we hypothesize that an amygdala to insula to accumbens circuit mediates social responses to stressed individuals. We will use tract specific descriptive and mechanistic methods to establish the necessity and sufficiency of insula-projecting amygdala neurons and accumbens-projecting insula neurons in social decision making. Using activity dependent genetic labeling of insular cortex neurons we will address whether insula-dependent approach and avoidant behaviors are mediated by the same or distinct subsets of insula neurons. This work will inform the development of new treatments of social disorders and provide mechanistic tests of major theoretical models of the social brain.

摘要自闭症谱系障碍等涉及社交行为的疾病越来越普遍，但这些疾病的病理生理学基础使研究人员感到困惑，目前的治疗方法令人遗憾，不足岛叶皮层与正常和病理性社会情感过程密切相关比如情感识别和移情。岛叶皮层接受来自杏仁核的主要输入，它可能是一个整合社会和情感信息的场所，导致社会方法的调节，通过岛叶投射到丘脑核的回避行为。利用一个简单的啮齿动物社会行为在一项老鼠在痛苦中表现出接近同类行为的测试中，我们假设杏仁核神经元到神经元回路介导压力个体的社会反应。我们将使用特定的道描述性和机械性方法来确定胰岛投射杏仁核的必要性和充分性神经元和投射神经元在社会决策中的作用。使用活动依赖遗传学岛叶皮层神经元的标记，我们将解决是否岛叶依赖的方法和回避行为是由相同或不同的神经元亚群介导的。这项工作将告知新的发展社会障碍的治疗，并提供社会大脑的主要理论模型的机械测试。