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Insular Cortex and Social Affect

岛叶皮质和社会影响

基本信息

批准号：
10087964
负责人：
John Paul Christianson
金额：
$ 39.13万
依托单位：
BOSTON COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10087964
关键词：
Address Adolescent Adult Affect Affective Age Amygdaloid structure Anatomy Animals Behavior Behavioral Behavioral Paradigm Brain Cells Cognition Cues Data Decision Making Detection Development Disease Distress Emotional Emotions Empathy Exposure to Fragile X Syndrome Functional Magnetic Resonance Imaging Functional disorder Gap Junctions Genetic Human Individual Insula of Reil Label Link Mediating Mental disorders Methods Modeling Neurons Nucleus Accumbens Pathologic Pathway interactions Positioning Attribute Primates Process Rattus Research Research Personnel Rewards Rodent Sensory Shapes Signal Transduction Social Behavior Social Interaction Stimulus Stress System Techniques Testing Theoretical model Work approach avoidance behavior approach behavior autism spectrum disorder base behavior test behavioral response blood oxygenation level dependent response emotional stimulus emotional symptom experience experimental study improved integration site loss of function member multidisciplinary multimodality neural circuit novel optogenetics pre-clinical preference prevent psychosocial response reward processing social social cognition social deficits social engagement social integration theories transmission process

项目摘要

Abstract Disorders involving social behaviors such as autism spectrum disorder are increasingly prevalent, yet the pathophysiological bases for these conditions elude researchers and current treatments are woefully inadequate. The insular cortex is highly implicated in both normal and pathological social affective processes such as emotion recognition and empathy. The insular cortex receives a major input from the amygdala and so it is likely a site of integration for social and emotional information leading to modulation of social approach and avoidance behaviors via insular projections to the nucleus accumbens. Using a simple rodent social behavioral test in which rats display approach behaviors to conspecifics in distress, we hypothesize that an amygdala to insula to accumbens circuit mediates social responses to stressed individuals. We will use tract specific descriptive and mechanistic methods to establish the necessity and sufficiency of insula-projecting amygdala neurons and accumbens-projecting insula neurons in social decision making. Using activity dependent genetic labeling of insular cortex neurons we will address whether insula-dependent approach and avoidant behaviors are mediated by the same or distinct subsets of insula neurons. This work will inform the development of new treatments of social disorders and provide mechanistic tests of major theoretical models of the social brain.

抽象的涉及社会行为的疾病（例如自闭症谱系障碍）越来越普遍，但研究人员无法找到这些病症的病理生理学基础，目前的治疗方法效果不佳不足。岛叶皮质与正常和病理的社会情感过程密切相关例如情感识别和同理心。岛叶皮层接收来自杏仁核的主要输入，因此它可能是社交和情感信息的整合场所，导致社交方式和情感的调节通过岛状投射到伏隔核的回避行为。使用简单的啮齿动物社会行为在一项测试中，老鼠对处于困境中的同种动物表现出接近行为，我们假设杏仁核岛叶到伏隔环可以调节对压力个体的社会反应。我们将使用特定区域确定岛叶杏仁核的必要性和充分性的描述性和机械性方法神经元和伏隔核投射岛叶神经元在社会决策中的作用。使用活动依赖遗传岛叶皮质神经元的标记我们将解决岛叶依赖性方法和回避行为是否由相同或不同的岛叶神经元亚群介导。这项工作将为新的开发提供信息治疗社会障碍并提供社会大脑主要理论模型的机械测试。