TB Alliance CETR Administrative Core

结核病联盟 CETR 管理核心

• 批准号: 9904473
• 负责人: Nader Fotouhi
• 金额: $ 21.79万
• 依托单位: GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9904473
• 关键词: Advanced Development; Advisory Committees; Collaborations; Communication; Communication Programs; Communities; Data; Data Reporting; Drug resistance; Drug resistance in tuberculosis; Elements; Goals; Institutes; Knowledge; Logistics; Manuscripts; Monitor; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Participant; Play; Preparation; Privatization; Production; Proteins; Protocols documentation; Publications; Regimen; Reporting; Research; Research Project Grants; Research Support; Resistance; Resources; Role; Scientific Advances and Accomplishments; Scientist; Secure; Sterilization; System; Translational Research; Translations; Tuberculosis; base; data management; data sharing; data tools; design; drug development; drug-sensitive; meetings; member; novel therapeutics; operation; programs; proteostasis; relational database; therapy duration; translational research program; web site

Project Summary/Abstract: Administrative Core. The primary objective of our Center of Excellence for Translational Research (CETR) program is to advance translational research focused on an integrated targeting of proteostasis in Mycobacterium tuberculosis (Mtb). The CETR will advance the development of new therapeutics for both drug-sensitive and drug-resistant tuberculosis (TB) in the form of universal regimens to reduce the duration of therapy and suppress the development of drug resistance. The Center—consisting of four research projects and three scientific cores will be managed and overseen by this Administrative Core whose main objective is to provide project management expertise and coordination of communication, data management and the sharing of scientific information. To achieve this objective, we have three specific Aims. Aim 1 will enhance collaboration by providing comprehensive administrative, logistical, and scientific support to all cores and projects. Aim 2 will promote strong collaboration through effective communication and engagement of Center members and NIAID project scientists. Aim 3 focuses on the creation of a website for dissemination and sharing of research project data emanating from this Center. As the Administrative Core, TB Alliance and Research Triangle Institute will engage in and promote collaboration across the research projects and cores to support and further the goals of the Center program. We will leverage the strengths represented by the Center members to accelerate translation of study findings to the scientific community by disseminating information and maximizing scientific exchange through sharing of data, tools, protocols, and resources.

项目摘要/摘要：行政核心。 我们的卓越转化研究中心（CETR）计划的主要目标 是推进翻译研究，重点是蛋白质稳定的综合靶向， 结核分枝杆菌（Mtb）。CETR将推动新的 治疗药物敏感和耐药结核病（TB）的形式普遍 方案，以减少治疗的持续时间和抑制耐药性的发展。 该中心由四个研究项目和三个科学核心组成， 由该行政核心监督，其主要目标是提供项目管理 交流、数据管理和科学信息共享的专门知识和协调 信息.为了实现这一目标，我们有三个具体目标。目标1将增强 通过向所有人提供全面的行政、后勤和科学支持进行合作 核心和项目。目标2将通过有效的沟通促进强有力的合作 以及中心成员和NIAID项目科学家的参与。目标3侧重于 建立一个网站，用于传播和分享由此产生的研究项目数据。 中心作为行政核心，结核病联盟和三角研究所将参与 并促进研究项目和核心之间的合作，以支持和促进 中心计划的目标。我们将利用中心所代表的优势， 成员通过传播研究成果， 信息和通过共享数据、工具、协议和 资源