Therapeutic in Situ Analgesic Implant for improved Oral-Facial Post-Operative Pain Outcomes

治疗性原位镇痛植入物可改善口腔面部术后疼痛结果

• 批准号: 9909401
• 负责人: ROBERT M CAUDLE
• 金额: $ 39.03万
• 依托单位: EPIGEN BIOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-19 至 2022-09-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9909401
• 关键词: Absence of pain sensation; Address; Adhesions; Analgesics; Applications Grants; Beds; Cheek structure; Clinical; Defect; Development; Face; Formulation; Health; Histopathology; Hydrogels; Implant; In Situ; Innovative Therapy; Medication Management; Modeling; Molar tooth; Operative Surgical Procedures; Oral; Oral Surgical Procedures; Oral cavity; Orofacial Pain; Oropharyngeal; Outcome Measure; Pain management; Parents; Peripheral; Pharmaceutical Preparations; Pharmacology; Polymers; Population; Postoperative Pain; Postoperative Period; Property; Regimen; Safety; Site; Small Business Innovation Research Grant; Surgical wound; Technology; Therapeutic; Time; Tissues; Tooth Extraction; Trigeminal nerve structure; United States National Institutes of Health; base; copolymer; design; experience; healing; improved; innovation; mechanical allodynia; medication safety; novel; novel strategies; novel therapeutics; orofacial; pain model; pain outcome; pain relief; pre-clinical; seal; wound

PROJECT SUMMARY Analgesia for post-operative populations remains a significant health need that calls for innovative therapies which improve both safety and outcome measures. Recent FDA drug safety warnings and studies focusing on post-operative analgesia have highlighted the imperative need for new approaches that can be utilized for common clinical scenarios. Accordingly, novel treatment options that are safe and afford additional benefit in relief of pain are needed. In this proposal, the development of an innovative surgical sealant technology is proposed that functions at the level of the surgical wound bed and actively delivers local pharmacologic agents to therapeutically address post-operative pain. New formulations of several analgesic regimens will be assessed for their ability to seal wounds and provide appropriate pain management.

项目摘要 术后人群的镇痛仍然是一个重要的健康需求， 创新的治疗方法，提高安全性和结果的措施。近期FDA药物 安全警告和关注术后镇痛的研究强调了 迫切需要可用于常见临床场景的新方法。 因此，安全并在缓解疼痛方面提供额外益处的新治疗选择 是必要的。在该提案中，创新外科密封剂技术的开发是 建议在手术伤口床水平发挥作用，并积极提供局部 用于治疗性解决术后疼痛的药物。新剂型 将评估几种镇痛剂方案封闭伤口并提供 适当的疼痛管理。