Optimizing Usability of the Orally Rehydrate Children at Home Mobile Application - Optimize ORCAH

优化儿童口服补液在家移动应用程序的可用性 - 优化 ORCAH

• 批准号: 9906781
• 负责人: Shawn Emery
• 金额: $ 14.57万
• 依托单位: DATA2CARE TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906781
• 关键词: Accident and Emergency department; Acute; Address; Adopted; Architecture; Area; Businesses; Caregivers; Child; Childhood; Clinical; Clinical Research; Collaborations; Colorado; Critical Illness; Data; Databases; Developed Countries; Developing Countries; Diarrhea; Dose; Effectiveness; Emergency Department Physician; Emergency Situation; Emergency department visit; Enrollment; Fostering; Gastroenteritis; Goals; Health; Health Care Costs; Health Care Visit; Home environment; Hospital Costs; Hospitals; Hour; Household; IV Fluid; Intervention; Interview; Knowledge; Liquid substance; Machine Learning; Marketing; Medical; Methods; Mobile Health Application; National Institute of Child Health and Human Development; Notification; Oral; Oral Rehydration Therapy; Outcome; Patients; Phase; Process; Rehydrations; Research; Research Personnel; Science; Scientist; Small Business Technology Transfer Research; Software Engineering; Target Populations; Techniques; Technology; Testing; United States; Universities; Update; User-Computer Interface; base; cloud based; commercial application; commercialization; comparative efficacy; cost; evidence base; experience; handheld mobile device; improved; informant; innovation; iterative design; mHealth; machine learning algorithm; mobile application; model development; mortality; novel; pediatric emergency; pediatric trauma; programs; prototype; public health intervention; recruit; simulation; software development; treatment as usual; urgent care; usability; user centered design

Project Summary/Abstract Acute gastroenteritis (AGE)--infectious diarrhea—is a common condition that is costly in the US and high- mortality in developing nations. The cornerstone of AGE management is oral rehydration therapy (ORT), an evidence-based technique that has saved over 54 million lives in the 50 years since its introduction. The problem we aim to address is ORT’s underuse in developed countries—specifically in the home setting. If widely adopted, ORT could reduce 80% of AGE-related healthcare visits and costs among children, eliminating 1.3 million emergency department visits and $1.5 billion in hospital costs annually. The product of this Phase I proposal is a minimum viable product of a mobile health application (app)--ORCAH (Orally Rehydrate Children at Home)—that guides caregivers of dehydrated children through administering ORT in the home. ORCAH's innovation is in the use of the mobile device's native functions for analytics, database parameters, timers, notifications, and process state—for a novel aim: making ORT accessible in the home setting in developed countries. We hypothesize we will achieve an effectiveness (percentage of ORT tasks completed) of 80%. We will achieve our objective through 3 Aims: Aim 1. Use key informant interviews with card sort testing to explicitly understand subjects’ prioritization of ORT workflow tasks and how to deliver these in a user- centered design interface, and thereby develop the optimal information architecture of ORCAH. Aim 2. Perform cycles of iterative, user-centered design using a synchronous remote platform to optimize the app’s usability. Aim 3. Pilot test ORCAH in a simulation context to demonstrate the feasibility of conducting a trial of the app using synchronous online methods. Based on the impact of ORT in developing settings, the gap presented by the absence of an intervention for improving home ORT use in developing countries, and the match between the key advantages of mobile health apps and the ORT underuse problem, we expect that the ORCAH app will provide a usability-optimized, effective and efficient technology for supporting home ORT delivery that will ultimately allow users to avoid costly and inconvenient ED visits. Objectives for Phase II include trialing ORCAH’s efficacy compared to usual care and further developing ORCAH to include a cloud-based machine learning algorithm that will continuously optimize the parameters of ORT dosing for each user based on patient- generated data and will provide generalizable evidence about ORT dosing. The long-term goals are to further develop the machine-learning functionalities to update best practices for ORT, and to develop ORCAH for developing settings. The market for ORCAH—caregivers of children with AGE—represents a promising commercial potential, as about 57.9 million children in the US experience an AGE episode annually of at least 24 hours duration. Data2Care’s commercialization strategy includes direct business-to-consumer marketing, as well as co-marketing with business partners including after-hours advice centers, rehydration fluid companies and urgent care centers.

项目总结/摘要 急性胃肠炎（AGE）-传染性胃肠炎-是一种常见的疾病，在美国是昂贵的， 发展中国家的死亡率。AGE管理的基础是口服补液疗法（ORT）， 这是一项循证技术，自推出以来的50年里，已挽救了5400多万人的生命。的 我们要解决的问题是ORT在发达国家的使用不足，特别是在家庭环境中。如果 ORT被广泛采用，可以减少80%的儿童与年龄相关的医疗保健就诊和费用， 1.3每年有100万人次的急诊就诊和15亿美元的住院费用。第一阶段的产品 建议是一个最低可行的产品的移动的健康应用程序（应用程序）-ORCAH（口服再水合物 家庭儿童）-指导脱水儿童的照顾者在家中进行ORT。 ORCAH的创新在于使用移动终端的本地功能进行分析，数据库参数， 定时器、通知和进程状态--为了一个新的目标： 发达国家我们假设我们将实现有效性（完成ORT任务的百分比） 的80%。我们将通过三个目标实现我们的目标：目标1。使用卡片排序的关键线人访谈 测试以明确了解受试者对ORT工作流程任务的优先级以及如何在用户中交付这些任务， 中心化的设计接口，从而开发ORCAH的最佳信息架构。目标2.执行 使用同步远程平台进行迭代、以用户为中心的设计周期，以优化应用程序的可用性。 目标3。在模拟环境中对ORCAH进行试点测试，以证明进行应用程序试用的可行性 使用同步在线方法。根据口服体液补充疗法在发展中国家的影响， 缺乏改善发展中国家家庭口服体液补充疗法使用的干预措施， 移动的健康应用程序的主要优势和ORT使用不足的问题，我们预计ORCAH应用程序将 提供可用性优化、有效且高效的技术来支持家庭ORT交付，该技术将 最终允许用户避免昂贵和不方便的艾德就诊。第二阶段的目标包括试验 ORCAH的疗效与常规护理相比，并进一步开发ORCAH，以包括基于云的机器 - 学习算法，其将基于患者持续优化每个用户的ORT给药参数- 生成的数据，并将提供有关ORT给药的可推广的证据。长期目标是进一步 开发机器学习功能，以更新ORT的最佳实践，并开发ORCAH 开发环境。市场ORCAH-照顾儿童与年龄-代表了一个有前途的 商业潜力，因为美国约有5790万儿童每年至少经历一次AGE发作， 持续24小时。Data 2Care的商业化战略包括直接的企业对消费者营销， 以及与商业伙伴合作营销，包括下班后咨询中心、补液液公司 紧急护理中心。