A comprehensive physiology and behavior system for homecage-based assessments

用于基于家庭笼的评估的综合生理学和行为系统

• 批准号: 9910014
• 负责人: Kevin D. Beck
• 金额: --
• 依托单位: VA NEW JERSEY HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910014
• 关键词: Animal Model; Animals; Anxiety Disorders; Area; Behavior; Biological; Body Temperature; Body Weight; Brain; Cardiac; Computers; Disease; Disease Progression; Drug Targeting; Electrocardiogram; Electroencephalography; Etiology; Expert Systems; Food; Foundations; Funding; Gulf War; Habitats; Healthcare Systems; Human; Intervention; Knowledge; Liquid substance; Liver diseases; Longitudinal Studies; Malignant Neoplasms; Measurable; Measurement; Measures; Medical; Metabolism; Mus; New Jersey; Observational Study; Parkinson Disease; Physiological; Physiology; Plant Roots; Polysomnography; Post-Traumatic Stress Disorders; Protocols documentation; Rattus; Research; Research Personnel; Rodent; Running; Shoes; Signal Transduction; Symptoms; System; Telemetry; Therapeutic Intervention; Time; Translating; Traumatic Brain Injury; base; behavior measurement; behavior observation; behavior test; behavioral study; bench to bedside; biobehavior; disability; drinking; experimental study; feeding; infancy; intervention effect; novel; programs; side effect; systems research

The VA New Jersey Health Care System (VANJHCS) is requesting the funds to purchase an all- in-one animal habitat that allows for measurements of behavior, metabolism, and physiology. The TSE PhenoMaster provides these capabilities. The PhenoMaster is a system that provides multiple measures without removing the rodent from the homecage. The PhenoMaster system requested has the capabilities of measuring general homecage activity, running wheel activity, body weight, feeding, and drinking, and, through an attached Stellar telemetry system, ECG, EEG, and core body temperature will be assessable for measurement. The PhenoMaster also has the capability of controlling access to food and fluids, as well as adjusting the tension on the running wheel. The VANJHCS has no such all-in-one system and would house this system within its Veterinary Medical Unit (VMU). We have identified four VA-funded major users of the PhenoMaster system. Three of these users conduct longitudinal studies with behavioral measures. This system would allow for some of those behaviors to be assessed without removing the animals from the homecage. The Stellar telemetry system would provide a whole new level of analysis of cardiac activity and brain activity both within the homecage and even when the animals are removed for specialized behavioral testing. In all, this system would provide the users more refined measures and additional measures that expand beyond the homecage system.

VA 新泽西州医疗保健系统 (VANJHCS) 正在请求资金购买全 一体化动物栖息地，可用于测量行为、新陈代谢和生理学。 TSE PhenoMaster 提供了这些功能。 PhenoMaster 是一个提供 在不将啮齿动物从笼子中移出的情况下采取多种措施。 PhenoMaster 系统 要求具有测量一般家庭笼活动、跑轮活动的能力， 体重、进食和饮水，以及通过附加的 Stellar 遥测系统、心电图、 脑电图和核心体温将可用于测量。 PhenoMaster 还 具有控制食物和液体的获取以及调节张力的能力 跑轮。 VANJHCS 没有这样的一体化系统，但会容纳该系统 在其兽医医疗单位 (VMU) 内。我们已经确定了 VA 资助的四个主要用户 PhenoMaster 系统。其中三个用户进行了行为纵向研究 措施。该系统将允许对其中一些行为进行评估，而无需 将动物从笼子中移出。恒星遥测系统将提供一个完整的 在家中甚至在室内对心脏活动和大脑活动进行新水平的分析 当动物被移走进行专门的行为测试时。总而言之，这个系统将 为用户提供更精细的措施和超出范围的附加措施 家庭笼系统。