A comprehensive physiology and behavior system for homecage-based assessments

退伍军人事务部新泽西州医疗保健系统(VANJHCS)正在申请资金，以购买所有- 集行为、新陈代谢和生理测量于一体的动物栖息地。 TSE PhenoMaster提供了这些功能。PhenoMaster是一个提供 采取多项措施，而不将啮齿动物从住所移走。PhenoMaster系统 Required具有测量一般回家活动、转轮活动、 体重，喂食，喝水，通过连接的恒星遥测系统，心电图， 脑电和核心体温将可用于测量。PhenoMaster还 有能力控制食物和液体的获取，以及调节 转向盘。VANJHCS没有这样的一体化系统，将容纳这个系统 在其兽医单位(VMU)内。我们确定了退伍军人管理局资助的四个主要用户 PhenoMaster系统。这些用户中有三人对行为进行了纵向研究 措施。该系统将允许评估其中一些行为，而不需要 把动物从院子里移走。恒星遥测系统将提供一个完整的 新层次的心脏活动和大脑活动的分析，无论是在家中还是在家中 当动物被移出进行专门的行为测试时。总而言之，这个系统将 为用户提供更精细的措施和扩展到 寄宿制度。

The VA New Jersey Health Care System (VANJHCS) is requesting the funds to purchase an all- in-one animal habitat that allows for measurements of behavior, metabolism, and physiology. The TSE PhenoMaster provides these capabilities. The PhenoMaster is a system that provides multiple measures without removing the rodent from the homecage. The PhenoMaster system requested has the capabilities of measuring general homecage activity, running wheel activity, body weight, feeding, and drinking, and, through an attached Stellar telemetry system, ECG, EEG, and core body temperature will be assessable for measurement. The PhenoMaster also has the capability of controlling access to food and fluids, as well as adjusting the tension on the running wheel. The VANJHCS has no such all-in-one system and would house this system within its Veterinary Medical Unit (VMU). We have identified four VA-funded major users of the PhenoMaster system. Three of these users conduct longitudinal studies with behavioral measures. This system would allow for some of those behaviors to be assessed without removing the animals from the homecage. The Stellar telemetry system would provide a whole new level of analysis of cardiac activity and brain activity both within the homecage and even when the animals are removed for specialized behavioral testing. In all, this system would provide the users more refined measures and additional measures that expand beyond the homecage system.