An integrated startle response, fear conditioning, and muscle tremor analysis system for rodents

退伍军人事务部新泽西州医疗保健系统(VANJHCS)正在申请资金购买 用于啮齿动物的替代惊吓/肌肉震颤系统。十八年后， 以前定制的系统年久失修，关键更换部件 不再供应。圣地亚哥研发生产的SR-Lab系统 仪器被认为是测量啮齿动物声音惊吓的目标标准 惊厥反射的反应和预脉冲抑制。这些是评估技术 东奥兰治退伍军人医学中心(EOVAMC)的研究人员历史上使用过 研究应激对惊吓反应的影响(作为创伤后应激的模型 精神障碍、创伤后应激障碍)。此外，EOVAMC研究人员最近的证据表明 脑部创伤后，惊恐反应会长时间受到抑制。 损伤(TBI)。EOVAMC的两个主要用户和两个次要用户需要SR-Lab 进一步加强他们在创伤后应激障碍和创伤后应激障碍领域的工作。另外两个主要用户 需要SR-Lab系统对其肌肉震颤进行行为评估 帕金森氏病(PD)啮齿动物模型。总而言之，这个系统将提供 确定VANJHCS的用户，并采取改进措施和需要采取的其他措施来 在没有原有制度的情况下，妥善执行其资助的项目。

The VA New Jersey Health Care System (VANJHCS) is requesting the funds to purchase a replacement startle/muscle tremor system for rodents. After eighteen years, the previous custom-made system has fallen upon disrepair and key replacement parts are no longer supplied. The SR-Lab System developed and produced by San Diego Instruments is considered the goal-standard for measuring the rodent acoustic startle response and pre-pulse inhibition of the startle reflex. These are assessment techniques historically used by the researchers at the East Orange VA Medical Center (EOVAMC) to study the effects of stress on startle reactivity (as a model of post-traumatic stress disorder, PTSD). In addition, recent evidence from EOVAMC researchers suggest that the startle response is dampened for long periods of time following traumatic brain injury (TBI). Two major users and two minor users at the EOVAMC require the SR-Lab System to further their work in the areas of PTSD and TBI. Two additional major users require the SR-Lab System for behavioral assessments of muscle tremors for their rodent models of Parkinson's Disease (PD). In all, this system would provide the identified users at VANJHCS with refined measures and additional measures needed to properly execute their funded projects in the absence of the previous system.