An integrated startle response, fear conditioning, and muscle tremor analysis system for rodents

啮齿类动物的综合惊吓反应、恐惧调节和肌肉震颤分析系统

• 批准号: 9794634
• 负责人: Kevin D. Beck
• 金额: --
• 依托单位: VA NEW JERSEY HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9794634
• 关键词: Acoustics; Affect; Animal Behavior; Animal Experimentation; Animal Model; Animals; Area; Behavior; Behavior assessment; Brain; Brain Diseases; Brain Injuries; Custom; Disease; Disease model; Erythropoietin; Etiology; Female; Foundations; Fright; Funding; Goals; Gold; Gulf War; Health; Healthcare Systems; Intervention; Laboratories; Long-Term Effects; Longitudinal Studies; Measurable; Measurement; Measures; Medical center; Mental disorders; Minor; Modeling; Motor; Mus; Muscle Tremors; Nerve Degeneration; New Jersey; Oranges; Parkinson Disease; Pharmaceutical Preparations; Post-Traumatic Stress Disorders; Rattus; Reflex action; Research Personnel; Research Project Grants; Rodent; Rodent Model; Sensory; Startle Reaction; Stimulus; Stress; Study models; System; Systems Analysis; Tactile; Techniques; Testing; Time; Trauma; Traumatic Brain Injury; Tremor; Veterans; Work; behavior measurement; conditioned fear; design; disability; instrument; male; nervous system disorder; neurobehavioral; novel; prepulse inhibition; programs; research and development; standard measure; systems research; tool; volatile organic compound

The VA New Jersey Health Care System (VANJHCS) is requesting the funds to purchase a replacement startle/muscle tremor system for rodents. After eighteen years, the previous custom-made system has fallen upon disrepair and key replacement parts are no longer supplied. The SR-Lab System developed and produced by San Diego Instruments is considered the goal-standard for measuring the rodent acoustic startle response and pre-pulse inhibition of the startle reflex. These are assessment techniques historically used by the researchers at the East Orange VA Medical Center (EOVAMC) to study the effects of stress on startle reactivity (as a model of post-traumatic stress disorder, PTSD). In addition, recent evidence from EOVAMC researchers suggest that the startle response is dampened for long periods of time following traumatic brain injury (TBI). Two major users and two minor users at the EOVAMC require the SR-Lab System to further their work in the areas of PTSD and TBI. Two additional major users require the SR-Lab System for behavioral assessments of muscle tremors for their rodent models of Parkinson's Disease (PD). In all, this system would provide the identified users at VANJHCS with refined measures and additional measures needed to properly execute their funded projects in the absence of the previous system.

VA 新泽西州医疗保健系统 (VANJHCS) 正在申请资金购买 用于啮齿类动物的替代惊吓/肌肉震颤系统。十八年后， 之前定制的系统因年久失修而损坏，关键更换部件已损坏 不再供应。圣地亚哥开发和生产的 SR-Lab 系统 仪器被认为是测量啮齿动物声惊吓的目标标准 惊吓反射的反应和预脉冲抑制。这些是评估技术 历史上东奥兰治退伍军人医疗中心 (EOVAMC) 的研究人员曾使用 研究压力对惊吓反应的影响（作为创伤后压力的模型） 障碍、创伤后应激障碍）。此外，EOVAMC 研究人员的最新证据表明 大脑受到创伤后，惊吓反应会在很长一段时间内受到抑制 损伤（TBI）。 EOVAMC 的两个主要用户和两个次要用户需要 SR-Lab 系统以进一步推进他们在创伤后应激障碍（PTSD）和创伤性脑损伤（TBI）领域的工作。另外两个主要用户 需要 SR-Lab 系统对他们的肌肉震颤进行行为评估 帕金森病（PD）的啮齿动物模型。总而言之，该系统将提供 确定了 VANJHCS 的用户，并采取了完善的措施和所需的额外措施 在没有以前的系统的情况下正确执行其资助的项目。