An integrated startle response, fear conditioning, and muscle tremor analysis system for rodents

啮齿类动物的综合惊吓反应、恐惧调节和肌肉震颤分析系统

• 批准号: 9794634
• 负责人: Kevin D. Beck
• 金额: --
• 依托单位: VA NEW JERSEY HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9794634
• 关键词: Acoustics; Affect; Animal Behavior; Animal Experimentation; Animal Model; Animals; Area; Behavior; Behavior assessment; Brain; Brain Diseases; Brain Injuries; Custom; Disease; Disease model; Erythropoietin; Etiology; Female; Foundations; Fright; Funding; Goals; Gold; Gulf War; Health; Healthcare Systems; Intervention; Laboratories; Long-Term Effects; Longitudinal Studies; Measurable; Measurement; Measures; Medical center; Mental disorders; Minor; Modeling; Motor; Mus; Muscle Tremors; Nerve Degeneration; New Jersey; Oranges; Parkinson Disease; Pharmaceutical Preparations; Post-Traumatic Stress Disorders; Rattus; Reflex action; Research Personnel; Research Project Grants; Rodent; Rodent Model; Sensory; Startle Reaction; Stimulus; Stress; Study models; System; Systems Analysis; Tactile; Techniques; Testing; Time; Trauma; Traumatic Brain Injury; Tremor; Veterans; Work; behavior measurement; conditioned fear; design; disability; instrument; male; nervous system disorder; neurobehavioral; novel; prepulse inhibition; programs; research and development; standard measure; systems research; tool; volatile organic compound

The VA New Jersey Health Care System (VANJHCS) is requesting the funds to purchase a replacement startle/muscle tremor system for rodents. After eighteen years, the previous custom-made system has fallen upon disrepair and key replacement parts are no longer supplied. The SR-Lab System developed and produced by San Diego Instruments is considered the goal-standard for measuring the rodent acoustic startle response and pre-pulse inhibition of the startle reflex. These are assessment techniques historically used by the researchers at the East Orange VA Medical Center (EOVAMC) to study the effects of stress on startle reactivity (as a model of post-traumatic stress disorder, PTSD). In addition, recent evidence from EOVAMC researchers suggest that the startle response is dampened for long periods of time following traumatic brain injury (TBI). Two major users and two minor users at the EOVAMC require the SR-Lab System to further their work in the areas of PTSD and TBI. Two additional major users require the SR-Lab System for behavioral assessments of muscle tremors for their rodent models of Parkinson's Disease (PD). In all, this system would provide the identified users at VANJHCS with refined measures and additional measures needed to properly execute their funded projects in the absence of the previous system.

VA新泽西医疗保健系统（VANJHCS）正在申请资金购买