Neuroimaging Markers of Emerging Dysfunction In Preclinical Alzheimer Disease

临床前阿尔茨海默病中出现的功能障碍的神经影像标志物

• 批准号: 9910360
• 负责人: BRIAN Andrew GORDON
• 金额: $ 12.46万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910360
• 关键词: Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer’s disease biomarker; Attention; Biological; Biological Assay; Biological Markers; Brain; Cerebrospinal Fluid; Clinical; Clinical Trials; Clinical assessments; Cognition; Cognitive; Cognitive deficits; Cohort Studies; Data; Dementia; Development; Diagnostic; Disease; Dorsal; Elderly; Episodic memory; Face; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Image; Impaired cognition; Impairment; Individual; Intervention; Knowledge; Maps; Measures; Medial; Mediating; Memory; Minor; Names; Neurobehavioral Manifestations; Neurons; Neuropsychological Tests; Normalcy; Outcome; Participant; Pathologic Processes; Pathology; Pattern; Phase; Positron-Emission Tomography; Prefrontal Cortex; Research; Research Personnel; Rest; Risk; Sampling; Senile dementia; Short-Term Memory; Stress; Support System; Symptoms; Techniques; Temporal Lobe; Time; Training; Work; advanced analytics; analytical tool; attentional control; base; brain health; cognitive neuroscience; cognitive process; cognitive task; cognitive testing; demented; dementia risk; functional MRI scan; healthy aging; improved; in vivo; innovation; long term memory; longitudinal design; memory encoding; neuroimaging; neuroimaging marker; outcome forecast; pre-clinical; recruit; relating to nervous system; skills; support network; tool

The objective of this proposal is to support the candidate's development and transition into an independent researcher. The outlined training plan will equip the applicant with the necessary skills to conduct innovative work that spans both primary research and clinical domains. The accrual of Alzheimer's disease (AD) pathology can begin decades before the onset of cognitive symptoms. Higher levels of pathology increase the risk of dementia, but the relationship between pathology and cognition is imperfect. Functional magnetic resonance imaging (fMRI) provides a way to non-invasively assess the integrity of networks in the brain that support cognition. As such it may provide a better measure of the brain's health than biomarkers of pathology alone. Prior work using fMRI has almost exclusively utilized only episodic memory tasks. This approach is limited as AD leads to deficits beyond memory domains. The goal of Aim 1 is to characterize alterations in neural activity related to preclinical levels of AD pathology using three tasks that respectively target attentional control, working memory, and episodic memory. The goal of Aim 2 is to compare the sensitivity of these task-based fMRI paradigms to resting-state fMRI. The goal of Aim 3 is to relate task-based fMRI data to longitudinal cognition and the transition from cognitive normality to an impaired state. This work will improve our understanding of the relationship between AD pathology and neuronal activity, as well as the relationship between such fMRI activity and longitudinal cognition.

本提案的目的是支持候选人的发展和过渡