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Neural representation of the geometry and functionality in a scene

场景中几何形状和功能的神经表示

基本信息

批准号：
9910403
负责人：
Michael E. McCloskey
金额：
$ 30.62万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2023-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The goal of the proposed research is to investigate how the brain represents scene geometry and functionality. Recognizing the visual environment is central to our daily interactions with the world. When we walk into a new space, we rapidly recognize whether there is a path to follow, whether there are crossable boundaries, and whether there are obstacles that block our view and potential navigation. The theoretical framework of this proposal is based on evidence that there are distinct but complementary levels of scene representation across a group of scene-selective regions in the brain (Park et al., 2011; Park et al., 2014; Park & Chun, 2009; Park, Chun, & Johnson, 2010; Park, Intraub, Yi, Widders, & Chun, 2007). The PI proposes that scene geometry (e.g., spatial layout, three-dimensional scene boundary) and functionality (e.g., navigability, limitations of a boundary) are two fundamental scene properties represented in these regions. Specific Aims: Aim 1 investigates whether the brain displays acute sensitivity to the presence of vertical boundaries, and how such sensitivity is modulated by the functional impediment that a boundary presents to the viewer's potential navigation. Aim 2 investigates the neural representation of the scene navigability, and how this representation differs from representation of scene geometry. Aim 3 investigates whether the neural representation of real world scenes is modulated by acquired knowledge about the spatio-temporal context of a scene, which are important for functionality of a scene. Throughout her aims, the PI tests medial temporal lobe regions in human adults that process scene and spatial information: with particular focus on anterior and posterior parahippocampal gyri and retrosplenial cortex. Methods include univariate and multi-voxel fMRI pattern analyses (linear support vector machine classification and representational similarity analysis) in combination with both region-of-interest (ROI) based and whole-brain based (search light) approaches. Hypothesis and preliminary results throughout the proposal suggest that scene geometry is represented in the parahippocampal gyrus, while scene functionality is represented in the retrosplenial cortex.

描述（由申请人提供）：拟议研究的目标是研究大脑如何表示场景几何和功能。识别视觉环境是我们与世界日常互动的核心。当我们走进一个新空间时，我们会迅速意识到是否有路可走，是否有可跨越的边界，是否有障碍物阻挡我们的视线和潜在的导航。该提议的理论框架基于以下证据：大脑中一组场景选择区域存在不同但互补的场景表征水平（Park et al., 2011; Park et al., 2014; Park & Chun, 2009; Park, Chun, & Johnson, 2010; Park, Intraub, Yi, Widders, & Chun, 2007）。 PI 提出场景几何（例如，空间布局、三维场景边界）和功能（例如，导航性、边界限制）是这些区域中表示的两个基本场景属性。具体目标：目标 1 研究大脑是否对垂直边界的存在表现出敏锐的敏感性，以及边界对观看者潜在导航带来的功能障碍如何调节这种敏感性。目标 2 研究场景导航性的神经表征，以及这种表征与场景几何表征的不同之处。目标 3 研究现实世界场景的神经表征是否受到有关场景时空上下文的已知知识的调节，这对于场景的功能很重要。在她的整个目标中，PI 测试了处理场景和空间信息的成年人内侧颞叶区域：特别关注海马旁回的前部和后部以及压后皮质。方法包括单变量和多体素 fMRI 模式分析（线性支持向量机分类和表征相似性分析），并结合基于感兴趣区域 (ROI) 和基于全脑（探照灯）的方法。整个提案的假设和初步结果表明，场景几何结构在海马旁回中表示，而场景功能在压后皮层中表示。