Opioid sparing potential of light-induced analgesia: a pilot trial of a novel, non-pharmacological treatment for pain

在医疗期间接触阿片类镇痛剂是阿片类药物流行的一个关键驱动因素。这些风险暴露是 广泛传播。减少阿片类药物的临床暴露对于预防药物滥用至关重要。然而阿片类药物仍然存在 治疗疼痛的基本一线药物，并且适当管理疼痛仍然至关重要。非阿片 疼痛治疗有助于解决阿片类药物/疼痛冲突。 该项目将研究一种新型的非药理学的阿片类药物的节省和缓解疼痛的潜力。 治疗疼痛。最近的临床前工作已经确定了绿色光的抗伤害感受作用。从视觉上- 特定颜色范围的光的介导的认知和生物效应在以下领域中被广泛认可： 影响和昼夜节律。对疼痛感知的类似影响了解较少。我们将进行试点试验 绿色光谱光暴露作为阿片类药物保留镇痛辅助剂的潜力。

Exposure to opioid analgesics during medical care is a key driver of the opioid epidemic. Such exposures are widespread. Reducing clinical opioid exposures is crucial for the prevention of drug abuse. Yet opioids remain essential first-line agents in treating pain, and it remains vital that pain be appropriately managed. Non-opioid pain treatments help to resolve the opioid/pain conflict. This project will examine the opioid-sparing and pain-relieving potential of a novel, non-pharmacological treatment for pain. Recent pre-clinical work has identified an anti-nociceptive effect of green light. Visually- mediated cognitive and biological effects of specific color-ranges of light are broadly recognized in areas of affect and circadian rhythm. Similar effects on pain perception are less understood. We will conduct a pilot trial of the potential for green-spectrum light exposure as an opioid-sparing analgesic adjunct.