Sex-specific adaptation to different resistance exercise programs in older adults

老年人对不同阻力运动项目的性别特异性适应

基本信息

  • 批准号:
    9912679
  • 负责人:
  • 金额:
    $ 48.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-01 至 2022-03-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY In general, men and women experience differing degrees of age-related decreases in physical function, with women having a greater prevalence of functional limitations and disability. A key predictor of this decrease in functional capacity is the reduction in leg muscle maximal power (product of force and velocity), which can be improved with exercise training. However, the development of exercise interventions to optimally improve skeletal muscle function in older adults has been difficult, in part because we now know that men and women respond differently to the same exercise training stimulus. In fact, the fundamental mechanisms by which habitual exercise improves physical function in older adults are still not well understood. The proposed studies, which build upon our recent work, are designed to address these knowledge gaps by examining the molecular and cellular mechanisms underlying the response to two distinct exercise training paradigms, and determining how these responses differ between older men and women. We hypothesize that molecular, cellular and whole muscle contractile performance will be most improved in men by traditional low-velocity, high-load resistance training, and in women by high-velocity, low-load power training. Moreover, sex-specific structural responses in myofilament remodeling, protein expression and post- translational modifications will explain these sex-specific performance adaptations to each modality. To test our hypotheses, data will be gathered from 50 healthy, sedentary older men and women (65-75 years) prior to and following a 16-week unilateral exercise training program in which one leg undergoes resistance training and the other power training. The Specific Aims of this project are to identify the sex-specific effects of low-velocity resistance training versus high-velocity power training on: Aim 1) skeletal muscle function at the molecular, cellular and whole muscle levels, and Aim 2) protein expression and modification as well as size at the molecular and cellular levels. Our within subject, unilateral intervention design provides a powerful model to minimize the effects of between-subject variability, and our translational approach will take advantage of our unique expertise with state-of-the-art measures from the molecular to whole body levels. Our results will challenge conventional wisdom by determining the sex-specific responses in intrinsic skeletal muscle adaptations to different exercise training programs. We will advance scientific knowledge by providing critically- needed information regarding the specific molecular and cellular determinants that support exercise-induced improvements in muscle performance. This knowledge will have a significant positive impact on the clinical care of older adults by providing novel insight about optimal exercise interventions to improve skeletal muscle function in each sex, and by identifying potential new therapeutic targets for pharmaceutical interventions. Thus, this project is highly relevant to the mission and vision of NIA to support biological research to mitigate conditions associated with aging that may limit health and independence in older adults.
一般来说,男性和女性经历不同程度的与年龄有关的减少, 身体功能,女性功能限制和残疾的患病率更高。一个关键 这种功能能力下降的预测因素是腿部肌肉最大功率(力的乘积)的降低 和速度),这可以通过运动训练来改善。然而,运动的发展 在老年人中进行最佳改善骨骼肌功能的干预一直很困难,部分原因是我们 现在知道,男性和女性对相同的运动训练刺激的反应不同。实际上 习惯性运动改善老年人身体机能的基本机制仍然不清楚 明白建议的研究,建立在我们最近的工作,旨在解决这些问题 通过研究对两种不同的免疫反应的分子和细胞机制, 运动训练范式,并确定老年男性和女性的这些反应有何不同。我们 假设分子、细胞和整个肌肉收缩性能在男性中将得到最大改善 传统的低速度、高负荷的抗阻训练,女子则采用高速度、低负荷的力量训练 训练此外,性别特异性的结构反应,肌丝重塑,蛋白质表达和后, 翻译修饰将解释这些性别特异性的性能适应每一种模式。来测试我们 假设,数据将收集自50名健康,久坐不动的老年男性和女性(65-75岁), 在为期16周的单侧运动训练计划之后,其中一条腿进行阻力训练, 另一种力量训练。本项目的具体目的是确定低流速的性别特异性影响 抗阻训练与高速力量训练对:目的1)骨骼肌功能的分子, 细胞和整个肌肉水平,和目标2)蛋白质表达和修饰以及大小在 分子和细胞水平。我们的受试者内单边干预设计提供了一个强大的模型, 最大限度地减少受试者之间差异的影响,我们的翻译方法将利用我们的 从分子水平到全身水平的最先进测量方法的独特专业知识。我们的结果将 通过确定内在骨骼肌的性别特异性反应来挑战传统观念 适应不同的运动训练计划。我们将通过提供批判性的- 需要关于支持运动诱导的特定分子和细胞决定因素的信息, 肌肉性能的改善。这些知识将对临床产生重大的积极影响。 通过提供有关改善骨骼肌的最佳运动干预的新见解来护理老年人 功能,并通过确定潜在的新的药物干预治疗目标。 因此,该项目与NIA的使命和愿景高度相关,以支持生物研究, 与衰老相关的疾病,可能会限制老年人的健康和独立性。

项目成果

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Mark Stuart Miller其他文献

Mark Stuart Miller的其他文献

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{{ truncateString('Mark Stuart Miller', 18)}}的其他基金

Sex-specific adaptation to different resistance exercise programs in older adults
老年人对不同阻力运动项目的性别特异性适应
  • 批准号:
    9311425
  • 财政年份:
    2017
  • 资助金额:
    $ 48.43万
  • 项目类别:
Single Skeletal Muscle Fiber Mechanics and Myosin Kinetics in Human Aging
人类衰老过程中的单骨骼肌纤维力学和肌球蛋白动力学
  • 批准号:
    8129609
  • 财政年份:
    2008
  • 资助金额:
    $ 48.43万
  • 项目类别:
Single Skeletal Muscle Fiber Mechanics and Myosin Kinetics in Human Aging
人类衰老过程中的单骨骼肌纤维力学和肌球蛋白动力学
  • 批准号:
    7917212
  • 财政年份:
    2008
  • 资助金额:
    $ 48.43万
  • 项目类别:
Single Skeletal Muscle Fiber Mechanics and Myosin Kinetics in Human Aging
人类衰老过程中的单骨骼肌纤维力学和肌球蛋白动力学
  • 批准号:
    7533063
  • 财政年份:
    2008
  • 资助金额:
    $ 48.43万
  • 项目类别:
Single Skeletal Muscle Fiber Mechanics and Myosin Kinetics in Human Aging
人类衰老过程中的单骨骼肌纤维力学和肌球蛋白动力学
  • 批准号:
    7677945
  • 财政年份:
    2008
  • 资助金额:
    $ 48.43万
  • 项目类别:
Single Skeletal Muscle Fiber Mechanics and Myosin Kinetics in Human Aging
人类衰老过程中的单骨骼肌纤维力学和肌球蛋白动力学
  • 批准号:
    8316222
  • 财政年份:
    2008
  • 资助金额:
    $ 48.43万
  • 项目类别:

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