2020 Bones and Teeth Gordon Research Conference and Gordon Research Seminar

项目摘要 60多年来，戈登骨骼和牙齿研究会议（B & T GRC） 本身作为一个论坛的前沿思想交流的生理学和病理学的骨，骨相关 组织和牙齿（在此称为骨骼）。在过去的十年里，戈登研究研讨会 (GRS)在GRC前一天举行，重点是学员和早期职业调查人员的参与 促进了下一代科学家和高级研究人员之间的密切互动。2020年B & T GRC和GRS将继续并加强这一传统。通过结构化的科学演示， 和非正式讨论，以及在6天的时间里举行的高度互动的海报会议（1天的GRS 加上5天的GRC），会议旨在展示最新的科学发现，并促进 跨学科合作。尽管我们对细胞、分子 以及控制正常骨骼发育和体内平衡的遗传机制，骨骼疾病， 包括骨质疏松症、骨关节炎、骨折修复失败、骨癌和牙周炎， 成人发病率和死亡率的主要因素。通过召集信号传导方面的专家， 细胞外基质（ECM）生物学，干细胞生物学，发育生物学，分子遗传学，生理学， 内分泌学，老龄化和新兴技术，2020年B & T GRC希望抓住巨大的 在该领域的势头和进展，激发新的研究方向，并促进旨在 推进骨骼竞技场的治疗发展。2020年B & T GRC的主题是The Life of the 骷髅首先介绍了信号电路，干细胞和ECM，我们检查事件 指导骨骼动态平衡的时间顺序，并在特定的时间拐点比较， 对比apapricular，轴和颅面骨骼反应。我们还讨论新兴技术 这让我们能够以新的方式研究骨骼生物学，并以关注是否 成人骨骼组织的修复/再生是对支配胚胎骨骼的原则的回归。 发展，或骨骼生物学的一个新阶段的代表，一个有争议的话题至关重要的发展， 在成人骨骼中成功的治疗方法。科学内容和合作精神 GRC和GRS与多个NIH研究所（包括NICHD，NIDCR， NIA和NIAMS。

PROJECT SUMMARY For more than 60 years, the Gordon Research Conference on Bones & Teeth (B&T GRC) has distinguished itself as a forum for the exchange of cutting-edge ideas on the physiology and pathology of bone, bone-related tissues and teeth (herein referred to as the skeleton). In the past decade, the Gordon Research Seminar (GRS) held one day before the GRC and focused on participation of trainees and early career investigators has promoted close interactions between next-generation scientists and senior investigators. The 2020 B&T GRC and GRS will continue and strengthen this tradition. Through structured scientific presentations, formal and informal discussions, and highly interactive poster sessions held over the course of 6 days (1day GRS plus 5 days GRC), the meetings are designed to showcase the latest scientific discoveries and to catalyze cross-disciplinary collaborations. Despite impressive advances in our understanding of the cellular, molecular and genetic mechanisms governing normal skeletal development and homeostasis, diseases of the skeleton, including osteoporosis, osteoarthritis, fracture repair failure, bone cancer, and periodontitis continue to be major contributors to adult morbidity and mortality. By bringing together experts in signal transduction, extracellular matrix (ECM) biology, stem cell biology, developmental biology, molecular genetics, physiology, endocrinology, aging, and emerging technologies, the 2020 B&T GRC hopes to capture the tremendous momentum and progress in the field, inspire new research directions, and foster new collaborations aimed at advancing therapeutic development in the skeletal arena. The theme of the 2020 B&T GRC is The Life of the Skeleton. Starting with an introduction to signaling circuits, stem cells, and ECM, we examine the events directing skeletal homeostasis in chronological order, and at specific temporal inflection points compare and contrast the appendicular, axial and craniofacial skeletal responses. We also discuss emerging technologies that allow us to investigate skeletal biology in new ways, and end our meeting by focusing on whether repair/regeneration of adult skeletal tissues is a return to principles that govern embryonic skeletal development, or representative of a new stage of skeletal biology, a controversial topic vital to development of successful therapeutic approaches in the adult skeleton. Both the scientific content and the collaborative spirit of the GRC and GRS are directly aligned with the missions of multiple NIH institutes including NICHD, NIDCR, NIA, and NIAMS.