2020 Bones and Teeth Gordon Research Conference and Gordon Research Seminar

项目总结 60多年来，戈登骨骼与牙齿研究会议(B&T GRC)一直表现突出 本身是一个交流关于骨的生理学和病理学的前沿思想的论坛，与骨相关的 组织和牙齿(这里称为骨骼)。在过去的十年里，戈登研究研讨会 (GRS)在GRC前一天举行，重点是实习生和早期职业调查人员的参与 促进了下一代科学家和高级调查人员之间的密切互动。2020年的B&T GRC和GRS将继续并加强这一传统。通过结构化的科学演示，正式 和非正式讨论，以及在6天(1天GRS)期间举行的高度互动的海报会议 外加5天的GRC)，这些会议旨在展示最新的科学发现并催化 跨学科协作。尽管我们对细胞、分子的理解取得了令人印象深刻的进展 以及控制正常骨骼发育和动态平衡的遗传机制，骨骼疾病， 包括骨质疏松症、骨关节炎、骨折修复失败、骨癌和牙周炎等 成人发病率和死亡率的主要贡献者。通过将信号转导专家聚集在一起， 细胞外基质生物学、干细胞生物学、发育生物学、分子遗传学、生理学 内分泌学、老龄化和新兴技术，2020 B&T GRC希望捕捉到 该领域的势头和进展，启发新的研究方向，并促进旨在 推进骨骼领域的治疗发展。2020年B&T GRC的主题是生活的 骷髅。从介绍信号电路、干细胞和ECM开始，我们考察了这些事件 以时间顺序指示骨骼动态平衡，并在特定的时间拐点比较和 对比阑尾、枢椎和颅面的骨骼反应。我们还讨论了新兴技术 这使我们能够以新的方式研究骨骼生物学，并以关注 成人骨骼组织的修复/再生是对支配胚胎骨骼的原则的回归 发育的，或代表骨骼生物学的一个新阶段的，这是一个对发展至关重要的有争议的话题 在成人骨骼上成功的治疗方法。既有科学内涵，又有合作精神 GRC和GRS的任务直接与多个NIH研究所的任务相一致，包括NICHD，NIDCR， Nia和NIAMS。

PROJECT SUMMARY For more than 60 years, the Gordon Research Conference on Bones & Teeth (B&T GRC) has distinguished itself as a forum for the exchange of cutting-edge ideas on the physiology and pathology of bone, bone-related tissues and teeth (herein referred to as the skeleton). In the past decade, the Gordon Research Seminar (GRS) held one day before the GRC and focused on participation of trainees and early career investigators has promoted close interactions between next-generation scientists and senior investigators. The 2020 B&T GRC and GRS will continue and strengthen this tradition. Through structured scientific presentations, formal and informal discussions, and highly interactive poster sessions held over the course of 6 days (1day GRS plus 5 days GRC), the meetings are designed to showcase the latest scientific discoveries and to catalyze cross-disciplinary collaborations. Despite impressive advances in our understanding of the cellular, molecular and genetic mechanisms governing normal skeletal development and homeostasis, diseases of the skeleton, including osteoporosis, osteoarthritis, fracture repair failure, bone cancer, and periodontitis continue to be major contributors to adult morbidity and mortality. By bringing together experts in signal transduction, extracellular matrix (ECM) biology, stem cell biology, developmental biology, molecular genetics, physiology, endocrinology, aging, and emerging technologies, the 2020 B&T GRC hopes to capture the tremendous momentum and progress in the field, inspire new research directions, and foster new collaborations aimed at advancing therapeutic development in the skeletal arena. The theme of the 2020 B&T GRC is The Life of the Skeleton. Starting with an introduction to signaling circuits, stem cells, and ECM, we examine the events directing skeletal homeostasis in chronological order, and at specific temporal inflection points compare and contrast the appendicular, axial and craniofacial skeletal responses. We also discuss emerging technologies that allow us to investigate skeletal biology in new ways, and end our meeting by focusing on whether repair/regeneration of adult skeletal tissues is a return to principles that govern embryonic skeletal development, or representative of a new stage of skeletal biology, a controversial topic vital to development of successful therapeutic approaches in the adult skeleton. Both the scientific content and the collaborative spirit of the GRC and GRS are directly aligned with the missions of multiple NIH institutes including NICHD, NIDCR, NIA, and NIAMS.