2020 Ligand Recognition & Molecular Gating GRC/GRS

2020年配体认可

• 批准号: 9913047
• 负责人: Alessio Accardi
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913047
• 关键词: ATP-Binding Cassette Transporters; Accounting; Address; Age; Binding; Cardiovascular Diseases; Carrier Proteins; Collaborations; Communities; Complex; Cryoelectron Microscopy; Development; Disabled Persons; Disease; Drug Targeting; Educational process of instructing; Endocrine System Diseases; Ensure; Equilibrium; Female; Fostering; Functional disorder; Future; G-Protein-Coupled Receptors; Gender; Goals; Health; Heart Diseases; Hour; Human; Intervention; Ion Channel; Ion Channel Protein; Italy; Joints; Ligand Binding; Ligands; Medical; Membrane Proteins; Metabolic Diseases; Minority Participation; Molecular; Molecular Conformation; Myopathy; Neuromuscular Diseases; Pharmaceutical Preparations; Pharmacologic Substance; Physiological; Physiology; Play; Postdoctoral Fellow; Process; Property; Protein Family; Proteins; Recruitment Activity; Regulation; Renaissance; Research; Research Personnel; Resort; Role; Science; Scientist; Senior Scientist; Signal Transduction; Slide; Structural Protein; Structure; Techniques; Woman; Work; experience; graduate student; improved; insight; interest; meetings; molecular recognition; neglect; nervous system disorder; novel strategies; particle; posters; programs; protein complex; protein function; public health relevance; research and development; solute; structured data; success; symposium; therapeutic target; transmission process

SUMMARY: The 2020 Gordon Research Conference (GRC) on Ligand Recognition and Molecular Gating will be held from March 15th-20th at the Renaissance Tuscany Il Ciocco Resort, Italy. The GRC will be preceded by the related Gordon Research Seminar (GRS), which is organized by and for young scientists (March 14th-15th). The topic of this GRC/GRS combination is unique, as it addresses the molecular mechanisms of three important classes of membrane proteins: ion channels, active transporters, and G-protein coupled receptors (GPCRs). These proteins are central to human physiology and their dysfunction leads to a large number of neuromuscular, endocrine and metabolic diseases. These proteins are major therapeutic targets; more than 50% of current drugs on the market target them. Therefore, elucidating their molecular mechanisms is essential to enable new opportunities for intervention, which ultimately will lead to improvement of human health. The central focus of this GRC/GRS is on the molecular mechanisms underlying ligand recognition and binding, ligand-induced conformational changes, solute transport, regulation of function, and signal transmission. Current focus is on elucidating the structures of these proteins and on how the structural data illuminates the mechanisms and physiological roles of these proteins. Our understanding of membrane protein function is undergoing a major leap forward, fueled by multiple technological breakthroughs, the most important of which is the revolution in electron cryo- microscopy that led to the determination of several medically important structures of human transporters, channels and signaling complexes, such as Na+ channels, multidrug ABC transporters and GPCR/G- protein complexes. Progress has also been made in understanding fundamental processes that are key to the function of these proteins, such as gating mechanisms of major channels, dynamic rearrangements and the formation of different signaling complexes. Efforts to identify the function of uncharacterized membrane protein families are also underway to understand their function in human physiology and disease. This GRC is unique as it brings together scientists who work on these three different classes of membrane proteins and are located on different continents, and thus do not meet regularly. They will benefit tremendously from these interactions as these membrane proteins share common mechanistic principles and can be studied by a vast array of techniques, many of which will be represented in this conference. The program will have around 40 speakers, a mix of well-established leaders in the field, young investigators, postdocs and graduate students. Nine speaker sessions and several poster sessions will address the major properties of transporters, ion channels, and GPCRs. The GRC/GRS on Ligand Recognition and Molecular Gating will provide a platform for the presentation and discussion of latest research results and for the establishment of new collaborations.

摘要：2020 年戈登配体识别和分子研究会议 (GRC) 门禁将于 3 月 15 日至 20 日在意大利托斯卡纳万丽西奥科度假村举行。 GRC将 在相关的戈登研究研讨会（GRS）之前，该研讨会由年轻人组织并为年轻人举办 科学家们（3月14日至15日）。这种 GRC/GRS 组合的主题是独特的，因为它解决了 三类重要膜蛋白的分子机制：离子通道、主动转运蛋白、 和 G 蛋白偶联受体 (GPCR)。这些蛋白质是人类生理学的核心， 功能失调导致大量神经肌肉、内分泌和代谢疾病。这些蛋白质 是主要的治疗靶点；目前市场上超过50%的药物都针对它们。所以， 阐明其分子机制对于提供新的干预机会至关重要，这 最终将改善人类健康。该 GRC/GRS 的中心焦点是分子 配体识别和结合的机制、配体诱导的构象变化、溶质 运输、功能调节和信号传输。当前的重点是阐明 这些蛋白质以及结构数据如何阐明这些蛋白质的机制和生理作用 蛋白质。在以下因素的推动下，我们对膜蛋白功能的理解正在经历重大飞跃： 多项技术突破，其中最重要的是电子冷冻技术的革命 显微镜技术确定了人体转运蛋白的几个医学上重要的结构， 通道和信号复合物，例如 Na+ 通道、多药 ABC 转运蛋白和 GPCR/G- 蛋白质复合物。在理解关键的基本过程方面也取得了进展。 这些蛋白质的功能，例如主要通道的门控机制、动态重排和 不同信号复合物的形成。努力识别未表征的膜的功能 蛋白质家族也正在进行中，以了解它们在人类生理学和疾病中的功能。 这个 GRC 是独一无二的，因为它汇集了研究这三类不同类别的科学家 膜蛋白位于不同的大陆，因此不会定期相遇。他们会 由于这些膜蛋白具有共同的机制，因此从这些相互作用中受益匪浅 原理，并且可以通过大量技术进行研究，其中许多技术将在本教程中得到体现 会议。该计划将有大约 40 名演讲者，其中包括该领域的知名领导者、 年轻的研究人员、博士后和研究生。九场演讲者会议和几场海报会议 将讨论转运蛋白、离子通道和 GPCR 的主要特性。配体上的 GRC/GRS 识别和分子门控将为最新研究成果的展示和讨论提供一个平台。 研究成果并建立新的合作。