Mapping the TNF Pathway: A qualitative and quantative molecular analysis of the components and post-translational modifications involved in physiological and pathological TNFR1 signalling

绘制 TNF 通路图谱：对生理和病理 TNFR1 信号传导涉及的成分和翻译后修饰进行定性和定量分子分析

• 批准号: nhmrc : 1025594
• 负责人: Dr Andrew Webb
• 金额: $ 42.43万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mapping-tnf-pathway-tnfr1-signalling/110439
• 关键词: Mapping; TNF; Pathway; qualitative; quantative

TNF is a master regulator of the inflammation response and dysregulated TNF signalling causes many human diseases. We will use a cutting edge mass spectrometry technique that we have developed to analyse molecules required for TNF signalling. Understanding how the TNF signalling works in all cell types and with different forms of ligands will open up therapeutic opportunities to selectively target TNF signalling in inflammatory diseases, such as Rheumatoid Arthritis and Cancer.

TNF是炎症反应的主要调节因子，TNF信号失调导致许多人类疾病。我们将使用我们开发的尖端质谱技术来分析TNF信号所需的分子。了解TNF信号如何在所有细胞类型和不同形式的配体中起作用，将为选择性靶向炎症性疾病（如类风湿关节炎和癌症）中的TNF信号提供治疗机会。