Mapping the TNF Pathway: A qualitative and quantative molecular analysis of the components and post-translational modifications involved in physiological and pathological TNFR1 signalling

肿瘤坏死因子是炎症反应的主要调节者，而失调的肿瘤坏死因子信号会导致许多人类疾病。我们将使用我们开发的尖端质谱学技术来分析肿瘤坏死因子信号所需的分子。了解肿瘤坏死因子信号如何在所有细胞类型和不同形式的配体中发挥作用，将为有选择地针对炎症性疾病(如类风湿性关节炎和癌症)的肿瘤坏死因子信号通路开辟治疗机会。

TNF is a master regulator of the inflammation response and dysregulated TNF signalling causes many human diseases. We will use a cutting edge mass spectrometry technique that we have developed to analyse molecules required for TNF signalling. Understanding how the TNF signalling works in all cell types and with different forms of ligands will open up therapeutic opportunities to selectively target TNF signalling in inflammatory diseases, such as Rheumatoid Arthritis and Cancer.